Hyperbranched poly(amine-ester) based hydrogels for controlled multi-drug release in combination chemotherapy

Zhang, Hongbin; Zhao, Chen; Cao, Hui; Wang, Guojie; Song, Li; Niu, Guoguang; Yang, Huai; Ma, Jie; Zhu, Siquan

doi:10.1016/j.biomaterials.2010.03.034

Cited by 58 publications

(40 citation statements)

References 52 publications

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“…Different from the previous attempts to deliver hydrophilic or hydrophobic molecules or both by a hydrogel [21,22,[44][45][46][47], water-insoluble doxorubicin (Dox) and paclitaxel (Ptx) were respectively encapsulated into amphiphilic copolymer nanoparticles and then upon temperature simulation, the hybrid aqueous solution of these nanoparticles with incompatible cores transformed into a semi-solid multicompartment hydrogel achieving the simultaneous and segregated storage. The obtained formulation would ensure the controlled release of each agent at the same location in a desired range of concentration for a long period.…”

Section: Introductionmentioning

confidence: 99%

An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform

Wang

Song

Zhang

et al. 2015

Journal of Controlled Release

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Section: Introductionmentioning

confidence: 99%

An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform

Wang

Song

Zhang

et al. 2015

Journal of Controlled Release

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“…24–29 For example, Zhong et al . had incorporated polyamidoamine (PAMAM) dendritic macromolecules within collagen scaffolds to improve mechanical properties, bio-stability, and the structural integrity of the crosslinked network.…”

Section: Introductionmentioning

confidence: 99%

Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell Adhesion Properties

et al. 2013

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Hyperbranched polyesters (HPE) have a high efficiency to encapsulate bioactive agents, including drugs, genes and proteins, due to their globe-like nanostructure. However, the use of these highly branched polymeric systems for tissue engineering applications has not been broadly investigated. Here, we report synthesis and characterization of photocrosslinkable HPE hydrogels with sustained drug release characteristics for cellular therapies. These HPE can encapsulate hydrophobic drug molecules within the HPE cavities, due to the presence of hydrophobic inner structure that is otherwise difficult to achieve in conventional hydrogels. The functionalization of HPE with photocrosslinkable acrylate moieties renders the formation of hydrogels with highly porous interconnected structure, and mechanically tough network. The compressive modulus of HPE hydrogels was tunable by changing the crosslinking density. The feasibility of using these HPE networks for cellular therapies was investigated by evaluating cell adhesion, spreading and proliferation on hydrogel surface. Highly crosslinked and mechanically stiff HPE hydrogels have higher cell adhesion, spreading, proliferation compared to soft and complaint HPE hydrogels. Overall, we showed that hydrogels made from HPE could be used for biomedical applications that require control cell adhesion and control release of hydrophobic clues.

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“…Figure 5 and 6 show the cumulative amounts of drugs released from the hydrogels at 37 ºC. Hydrogels showed an initial burst release of aminophylline already reported and considered to be due to the localization of this drug near the hydrogel surface [21][22][23][24] . At the initial stages of the release, there was a high concentration gradient between the hydrogel surface and the release medium.…”

Section: In Vitro Single Drug Releasementioning

confidence: 99%

“…The mutual interactions between the drugs and the PNIPA hydrogel influence the differences in the release profiles for the drugs. In fact, interactions between amine groups in the drugs and in the hydrogel matrix have been proven to entrap and greatly restrict the remaining drug from releasing [21] . The initial release rate of aminophylline was 40% in half an hour and 58% of the loaded drug was released in 150 minutes.…”

Section: In Vitro Single Drug Releasementioning

confidence: 99%

Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels

Castro

Mosquera

Katime³

2012

Nanomaterials and Nanotechnology

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We used temperature-sensitive poly(Nisopropylacrylamide) hydrogels as drug delivery systems, so changes in body temperature induced by pathogens could act like external stimuli to activate controlled release of the drugs incorporated in the hydrogel. In the distilled water combined release studies, we chose two model drugs: aminophylline and triamterene. The amount of drug released was measured by UV-Vis spectroscopy following the evolution of the absorption peaks of aminophylline (271 nm) and triamterene (365 nm). The maximum release time was greater for triamterene than for aminophylline at 37 ºC, so these time-release profiles enabled the active ingredients to work over different periods of time. By increasing molar mass or solubility of the drug, we observed that the diffusion coefficient decreased. On the contrary, increasing hydrophobicity of the drug leads to a diffusion coefficient increase. The evolution of pore size distribution of hydrogels during loading and releasing was measured by quasi-elastic light scattering and by environmental electronic scanning microscope. When loading and releasing the drugs, the pore size of the hydrogel decreased and increased again without reaching the initial pore size of the hydrogel, respectively. We observed that the greater the concentration of drug loaded into the hydrogel, the greater the reduction in pore size.

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Hyperbranched poly(amine-ester) based hydrogels for controlled multi-drug release in combination chemotherapy

Cited by 58 publications

References 52 publications

An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform

An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform

Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell Adhesion Properties

Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels

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