Hyperbaric oxygen treatment as an adjuvant to reconstructive vascular surgery in trauma

Monies-Chass, I.; Hashmonai, M; Hoerer, Dory; Kaufman, Theodor; Steiner, E; Schramek, A

doi:10.1016/0020-1383(77)90101-2

Cited by 25 publications

(12 citation statements)

References 2 publications

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“…Moreover, contrary to another study [Karpati et al, 1974], no increased number of satellite cells or other signs of regeneration were noted in the present material. Clinical observations of similar progressive damage after revas cularization have been made in humans [Winniger, 1973;Monies-Chass et al, 1977], However, in the present investigation there was a striking discrepancy between the aggravation of the morphological lesions which occurred after restoration of blood circulation and the functional recovery of the affected limbs. A possible explanation may be that muscle fibres which have been affected by anoxia continue with progressing alterations, but as these are only a small number out of the total, the bulk of the mus cle is not functionally impaired and recov ers.…”

Section: Discussioncontrasting

confidence: 50%

“…Yet, if by longer or more severe ischaemia a larger part of the muscle is affected, there will be no functional recov ery. The progressing nature of the ischaemic muscle changes may possibly explain the clinical observation previously reported in humans of ischaemic limbs deteriorating after and despite restitution of their blood circulation [Monies-Chass et al, 1977].…”

Section: Discussionmentioning

confidence: 65%

“…However, the evolution following revascularization of these ischaemic lesions at the ultrastructural level was not reported. The point is of particular interest as progressing ischaemia of human limbs after and despite effective restitution of their blood circulation has been reported [ Monies-Chass et al, 1977],…”

Section: Introductionmentioning

confidence: 99%

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Progressing Alterations in Transient Ischemia of Skeletal Muscles: An Ultrastructural Study

Ludatscher¹,

Hashmonai²,

Monies-Chass³

et al. 1981

Cells Tissues Organs

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Ultrastructural muscle changes resulting from temporary anoxia and their evolution were studied in dogs. Ischaemia of the hind limb was produced by subcutaneous ligation of all muscles of the thigh and clamping of the femoral artery. Revascularization was obtained by declamping and removal of the muscle ligature. The period of ischaemia ranged from 4½ to 7 h, the latter being the upper limit allowing functional recovery after revascularization. 6–7 h of ischaemia revealed focal degenerative changes of varied intensity. These consisted of enlarged mitochondria with ruptured criptae, small pads of glycogen granules and accumulation of lipid vacuoles. The tubules of sarcoplasmic reticulum contained dense, fine-granular material. Focal myofibrillar distruction and disrupture of the Z line were encountered in half of the cases. The myofibrillar damage was more severe 9 days after revascularization of the muscles. The functional recovery of the ischaemic limbs in the present study may be due to the focal nature of these changes.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 65%

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Progressing Alterations in Transient Ischemia of Skeletal Muscles: An Ultrastructural Study

Ludatscher¹,

Hashmonai²,

Monies-Chass³

et al. 1981

Cells Tissues Organs

Self Cite

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“…Of these, most notable is the reduction of inflammation brought about by several mechanisms, including reduced production of immunity and inflammatory cytokines. Hyperbaric oxygen also stimulates wound repair, increased fibroblast production and collagen formation and capillary angiogenesis [25][26][27][28][29]. This in turn creates the correct circumstances for an ulcerated bleeding point to heal.…”

Section: Intravesical Formalinmentioning

confidence: 99%

The management of cyclophosphamide‐induced haematuria

Mukhtar

Woodhouse

2010

BJU International

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“…12 Numerous studies support the use of hyperbaric oxygen as adjunctive treatment for nonhealing lower extremity wounds in diabetics, 10,11 compromised tissue flaps and grafts, 13 and radiation-induced ischemic osteonecrosis.…”

mentioning

confidence: 99%

Hyperoxia Causes Regression of Vitreous Neovascularization by Downregulating VEGF/VEGFR2 Pathway

Liu

Zhang

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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,4,7 PURPOSE. Neovascularization (NV) is a sight-threatening complication of retinal ischemia in diabetes, retinal vein occlusion, and retinopathy of prematurity. Current treatment modalities, including laser photocoagulation and repeated intraocular injection of VEGF antagonists, are invasive and not always effective, and may carry side effects. We studied the use of hyperoxia as an alternative therapeutic strategy for regressing established vitreous NV in a mouse model of oxygen-induced ischemic retinopathy.METHODS. Hyperoxia treatment (HT, 75% oxygen) was initiated on postnatal day (P)17 after the onset of vitreous NV. Immunohistochemistry and quantitative PCR were used to assess retinal vascular changes in relation to apoptosis, and expression of VEGFR2 and inflammatory molecules. Effects of intravitreal injections of VEGF-A, VEGF-E, PlGF-1, and VEGF trap were also studied.RESULTS. HT selectively reduced NV by 70% within 24 hours. It robustly increased the level of cleaved caspase-3 in the vitreous NV between 6 and 18 hours and promoted infiltration of macrophage/microglial cells. The HT-induced apoptosis was preceded by a significant reduction in VEGFR2 expression within the NV and an increase in VEGFR2 within the surrounding neural tissue. Intravitreal VEGF-A and VEGF-E (VEGFR2 agonist) but not PlGF-1 (VEGFR1 agonist) prevented HT-induced apoptosis and regression of NV. In contrast, VEGF trap and VEGFR2 blockers mimicked the effect of HT. However, intravitreal VEGF trap induced increases in inflammatory molecules while HT did not have such unwanted effect.CONCLUSIONS. HT may be clinically useful to specifically treat proliferative NV in ischemic retinopathy. (Invest Ophthalmol Vis Sci. 2013;54:918-931)

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Hyperbaric oxygen treatment as an adjuvant to reconstructive vascular surgery in trauma

Cited by 25 publications

References 2 publications

Progressing Alterations in Transient Ischemia of Skeletal Muscles: An Ultrastructural Study

Progressing Alterations in Transient Ischemia of Skeletal Muscles: An Ultrastructural Study

The management of cyclophosphamide‐induced haematuria

Hyperoxia Causes Regression of Vitreous Neovascularization by Downregulating VEGF/VEGFR2 Pathway

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