Hyperbaric oxygen therapy for acute coronary syndrome

Abstract

For people with ACS, there is some evidence from small trials to suggest that HBOT is associated with a reduction in the risk of death, the volume of damaged muscle, the risk of MACE and time to relief from ischaemic pain. In view of the modest number of patients, methodological shortcomings and poor reporting, this result should be interpreted cautiously, and an appropriately powered trial of high methodological rigour is justified to define those patients (if any) who can be expected to derive most benefit from HBOT. The routine application of HBOT to these patients cannot be justified from this review.

Unreliable Early Neuroprognostication After Severe Carbon Monoxide Poisoning Is Likely Due to Cytopathic Hypoxia: A Case Report and Discussion

“…It is noteworthy that systematic reviews conclude that the routine application of hyperbaric oxygen therapy to improve outcomes cannot be justified in conditions with similar inflammatory cascades, including acute ischemic stroke, traumatic brain injury, and acute coronary syndrome. [25][26][27] The 10th European consensus conference on hyperbaric medicine states that hyperbaric oxygen therapy is not indicated for the acute phase of stroke nor for traumatic brain injury outside of a clinical trial. 28 Fourth, we believe that in this case hyperbaric oxygen therapy may have increased morbidity.…”

Unreliable Early Neuroprognostication After Severe Carbon Monoxide Poisoning Is Likely Due to Cytopathic Hypoxia: A Case Report and Discussion

“…It is noteworthy that systematic reviews conclude that the routine application of hyperbaric oxygen therapy to improve outcomes cannot be justified in conditions with similar inflammatory cascades, including acute ischemic stroke, traumatic brain injury, and acute coronary syndrome. [25][26][27] The 10th European consensus conference on hyperbaric medicine states that hyperbaric oxygen therapy is not indicated for the acute phase of stroke nor for traumatic brain injury outside of a clinical trial. 28 Fourth, we believe that in this case hyperbaric oxygen therapy may have increased morbidity.…”

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

“…Furthermore, hs-CRP, a maker of the inflammatory response involved in many types of acute and chronic physiological inflammation, is thought to be closely related to SCF onset [10,11]. According to Bennett's report [15], HBO treatment can reduce myocardial ischemia and mortality rate of patients suffering from acute coronary syndrome. Another study from Khan et al [16] showed that HBO treatment can increase myocardial oxygen supply, and enhance the expression of vascular endothelial growth factors and the recovery of cardiomyocytes, and can also significantly improve the efficacy of stem-cell transplantationtreated myocardial infarct rats.…”

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

“…However, the small number of studies, the modest numbers of patients, and the methodological and reporting inadequacies of the primary studies demand a cautious interpretation. Thus, the adjunctive application of HBOT in these patients cannot be recommended to be introduced into routine clinical practice [41].…”

Unreliable Early Neuroprognostication After Severe Carbon Monoxide Poisoning Is Likely Due to Cytopathic Hypoxia: A Case Report and Discussion

“…It is noteworthy that systematic reviews conclude that the routine application of hyperbaric oxygen therapy to improve outcomes cannot be justified in conditions with similar inflammatory cascades, including acute ischemic stroke, traumatic brain injury, and acute coronary syndrome. [25][26][27] The 10th European consensus conference on hyperbaric medicine states that hyperbaric oxygen therapy is not indicated for the acute phase of stroke nor for traumatic brain injury outside of a clinical trial. 28 Fourth, we believe that in this case hyperbaric oxygen therapy may have increased morbidity.…”

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

“…Furthermore, hs-CRP, a maker of the inflammatory response involved in many types of acute and chronic physiological inflammation, is thought to be closely related to SCF onset [10,11]. According to Bennett's report [15], HBO treatment can reduce myocardial ischemia and mortality rate of patients suffering from acute coronary syndrome. Another study from Khan et al [16] showed that HBO treatment can increase myocardial oxygen supply, and enhance the expression of vascular endothelial growth factors and the recovery of cardiomyocytes, and can also significantly improve the efficacy of stem-cell transplantationtreated myocardial infarct rats.…”

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

“…However, the small number of studies, the modest numbers of patients, and the methodological and reporting inadequacies of the primary studies demand a cautious interpretation. Thus, the adjunctive application of HBOT in these patients cannot be recommended to be introduced into routine clinical practice [41].…”

Unreliable Early Neuroprognostication After Severe Carbon Monoxide Poisoning Is Likely Due to Cytopathic Hypoxia: A Case Report and Discussion

“…It is noteworthy that systematic reviews conclude that the routine application of hyperbaric oxygen therapy to improve outcomes cannot be justified in conditions with similar inflammatory cascades, including acute ischemic stroke, traumatic brain injury, and acute coronary syndrome. [25][26][27] The 10th European consensus conference on hyperbaric medicine states that hyperbaric oxygen therapy is not indicated for the acute phase of stroke nor for traumatic brain injury outside of a clinical trial. 28 Fourth, we believe that in this case hyperbaric oxygen therapy may have increased morbidity.…”

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

“…Furthermore, hs-CRP, a maker of the inflammatory response involved in many types of acute and chronic physiological inflammation, is thought to be closely related to SCF onset [10,11]. According to Bennett's report [15], HBO treatment can reduce myocardial ischemia and mortality rate of patients suffering from acute coronary syndrome. Another study from Khan et al [16] showed that HBO treatment can increase myocardial oxygen supply, and enhance the expression of vascular endothelial growth factors and the recovery of cardiomyocytes, and can also significantly improve the efficacy of stem-cell transplantationtreated myocardial infarct rats.…”

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

“…However, the small number of studies, the modest numbers of patients, and the methodological and reporting inadequacies of the primary studies demand a cautious interpretation. Thus, the adjunctive application of HBOT in these patients cannot be recommended to be introduced into routine clinical practice [41].…”