Hyperbaric Oxygen Suppresses Hypoxic-Ischemic Brain Damage in Newborn Rats

Zhu, Min; Lu, Mengru; Li, Qingjie; Zhang, Zhuo; Wu, Ze; Li, Jie; Lai, Qi; Xu, Yun; Wang, Zhongyuan

doi:10.1177/0883073814530500

Cited by 21 publications

(18 citation statements)

References 10 publications

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“…There are many factors that cause aging, including telomere shortening, oncogene activation, and DNA damage caused by reactive oxygen species (ROS), among which the most critical factor is the imbalance of oxygen free radical metabolism [ 2 ]. Free radical theory holds that because of the imbalance of free radical metabolism, the structure and function of tissues and organs are in disorder, which causes the body aging [ 3 ]. There are two signaling pathways associated with aging, p53-p21-Rb pathway and p16-pRb pathway [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D‐Galactose

Chen

Long

Guo

2016

Evidence-Based Complementary and Alternative Medicine

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The antiaging effect of Inula britannica flower total flavonoids (IBFTF) on aging mice induced by D-galactose and its mechanism was examined in this study. From the results, the biochemical indexes and histological analysis of skin tissues showed that IBFTF could effectively improve the antioxidant enzyme activity of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of skin tissue, and decrease the malondialdehyde (MDA) content. Besides, IBFTF could maintain the skin collagen, hydroxyproline (Hyp), dermal thickness, and moisture content. Meanwhile, IBFTF could significantly reduce the number of cells arrested in G0/G1 phase, and from the point of view of protein and mRNA expression level in skin tissue, IBFTF could significantly increase the expression of Sirt1 and CyclinD1 but decrease the expression of p16 and p21, and its effect was not less than that of the well-known vitamin E (VE). Overall, these results seem to be implying that IBFTF is a potential natural anti-skin aging agent with great antioxidant ability.

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Section: Introductionmentioning

confidence: 99%

Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D‐Galactose

Chen

Long

Guo

2016

Evidence-Based Complementary and Alternative Medicine

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“…In accordance with previous protocols (14,15), the rats in the HBO group and HIBD+HBO group were placed into a hyperbaric chamber (model YLC 0.5/1A baby hyperbaric chamber; China State Shipbuilding Corporation 701, Beijing, China) 24 h after surgery and were administered HBO treatment (100% oxygen under 0.02 MPa for 30 min). The pressure gradually reached a maximum of 0.02 MPa in 15 min, which was maintain for another 30 min, and gradually reduced to normal.…”

Section: Preparation For Animal Model and Groupingmentioning

confidence: 99%

Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage

Chen

et al. 2016

Biomedical Reports

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Abstract. The aim of the present study was to investigate the effect of hyperbaric oxygen (HBO) on lipid peroxidation and visual development in a neonatal rat model of hypoxic-ischemic brain damage (HIBD). The rat models of HIBD were established by delayed uterus dissection and were divided randomly into two groups (10 rats each): HIBD and HBO-treated HIBD (HIBD+HBO) group. Another 20 rats that underwent sham-surgery were also divided randomly into the HBO-treated and control groups. The rats that underwent HBO treatment received HBO (0.02 MPa, 1 h/day) 24 h after the surgery and this continued for 14 days. When rats were 4 weeks old, their flash visual evoked potentials (F-VEPs) were monitored and the ultrastructures of the hippocampus were observed under transmission electron microscope. The levels of superoxide dismutase (SOD) and malonyldialdehyde (MDA) in the brain tissue homogenate were detected by xanthine oxidase and the thiobarbituric acid colorimetric method. Compared with the control group, the ultrastructures of the pyramidal neurons in the hippocampal CA3 area were distorted, the latencies of F-VEPs were prolonged (P<0.01) and the SOD activities were lower while the MDA levels were higher (P<0.01) in the HIBD group. No significant differences in ultrastructure, the latency of F-VEPs or SOD/MDA levels were identified between the HBO-treated HIBD group and the normal control group (P>0.05). HBO enhances antioxidant capacity and reduces the ultrastructural damage induced by hypoxic-ischemia, which may improve synaptic reconstruction and alleviate immature brain damage to promote the habilitation of brain function. IntroductionHypoxic-ischemic brain damage (HIBD) occurs at a rate of 3-5/1,000 full-term live births in developed countries and ≤10-fold higher in developing countries (1). Following hypoxia-ischemia (HI), ~45% of newborns succumb or have permanent cognitive impairments, potentially including cerebral palsy, and there are currently no effective therapies (2).Hyperbaric oxygen (HBO) therapy has been identified as a clinical therapy for HIBD for a number of years. Animal experiments and clinical trials have shown that HBO performed within 6 h after HIBD may achieve favorable outcomes and promote the long-term neurological recovery (3-6). In addition, numerous studies in China have demonstrated that HBO can reduce the disability and mortality of HIBD (7). However, there are concerns regarding the safety and validity of HBO treatment due to oxygen toxicity, which may increase the infarct area (3). A previous study demonstrated an increase in lipid and protein oxidation products in the lung tissues of rats accompanied by increased antioxidant enzyme activities when HBO was continued for >20 sessions (8). In addition to the lung being the entering site of hyperoxic injuries, CNS is mainly accepted as another important target for oxygen exposure in toxic amounts (9). However, whether HBO will exacerbate lipid peroxidation causing secondary injury to the brain or lead to neonatal pulmonary and retina...

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“…Previous studies have demonstrated that there is an optimal therapeutic time frame for HBO treatment in neonatal rats with hypoxic-ischemic brain damage (78–80). However, to the best of our knowledge, the optimal timing of treatment for patients with brain injury remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Dong

et al. 2018

Exp Ther Med

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The present review evaluated the effect of hyperbaric oxygenation (HBO) therapy on post-concussion syndrome (PCS). Searches for publications from the earliest date possible up until the first week of 2016 were conducted using the electronic databases Cochrane, EBSCOhost, Embase, Ovid MEDLINE, PubMed and Web of Science. Additional trials were identified through reference list scanning. Randomized controlled trials assessing the effectiveness of HBO therapy in PCS were selected and tested for eligibility for inclusion in the present review. Two independent reviewers conducted data extraction and the Cochrane Collaboration's recommended method was used to assess the risk of bias in each study included. Review Manager 5.3 software was used for data synthesis and analysis and the standardized mean difference (SMD) or mean difference (MD) was estimated with a fixed or random effects model using a 95% confidence interval (CI). A total of 127 articles were identified, 4 of which were eligible for final analysis. The meta-analysis identified no difference in the Rivermead Post-Concussion Symptoms Questionnaire (MD=1.23; 95% CI, −3.47-5.94; P>0.05; I2=35%) or Post-Traumatic Stress Disorder Checklist (PCL) scores (SMD=0.12; 95% CI, −0.31-0.54; P>0.05; I2=0%) scores between groups receiving different oxygen doses. The differences in PCL scores (SMD=−0.13, 95% CI, −0.80-0.53; P>0.05; I2=63%) and neurobehavioral symptoms (SMD=−1.00, 95% CI, −2.58-0.58; P>0.05; I2=92%) between the HBO and sham groups were not significant. The current study demonstrated that HBO therapy has no significant effect on PCS compared with the sham group. Therefore, it was determined that effective design and execution of a large clinical trial, which includes treatment, control and sham groups is required in the future.

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Hyperbaric Oxygen Suppresses Hypoxic-Ischemic Brain Damage in Newborn Rats

Cited by 21 publications

References 10 publications

Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D‐Galactose

Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D‐Galactose

Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

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