Hydroxylated fullerenes inhibit neutrophil function in fathead minnow (Pimephales promelas Rafinesque, 1820)

Jovanović, Boris; Anastasova, Lora; Rowe, Eric; Palić, Dušan

doi:10.1016/j.aquatox.2010.11.002

Cited by 50 publications

(45 citation statements)

References 49 publications

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“…The differences observed can be attributed to differences between species, cell types or the analyzed nanoparticles. The key difference between our investigations and the studies of Jovanović et al (2011a, b) was, however, the time of cell incubation with NPs which was only 2 hours in the cited studies and 24 hours in our experiment. The above parameter could significantly influence the results, in particular in peripheral blood phagocytes.…”

Section: Discussioncontrasting

confidence: 43%

“…The engulfed nanoparticles are not destroyed inside phagocytes but are merely removed by exocytosis or apoptosis, and in the case of neutrophils -by NETosis (Jovanović and Palić 2012). Jovanović et al (2011a, b) investigated the in vitro and ex vivo effects of various nanoparticles (TiO2, hydroxylated fullerenes) on the activity of neutrophils isolated from the anterior kidney of the fathead minnow (Pimephales promelas). The results obtained differed subject to the type of tested nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

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The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity

Małaczewska

Siwicki

2013

Polish Journal of Veterinary Sciences

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The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity AbstractThe growing popularity of nanotechnology in the past decade has increased nanomaterial concentrations in the environment and the risk of their toxicity for aquatic organisms. Metal nanoparticles, which are easily absorbed and accumulated by fish, are probably able to interact directly with their immunocompetent cells. The objective of this study was to evaluate the in vitro effect of commercially available silver, gold and copper nanocolloids on the rainbow trout leukocyte and splenocyte activity. At high concentrations, all of the nanocolloids studied had adverse effects on the proliferative response of trout lymphocytes, and the most toxic of them, silver, decreased also the respiratory burst activity of splenocytes. Low concentrations of silver nanocolloid, however, had a stimulating effect on the lymhocyte proliferation.

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity

Małaczewska

Siwicki

2013

Polish Journal of Veterinary Sciences

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“…Both DNAse and inhibition of NE have been shown to abrogate NET formation both in vitro and in vivo (48,53,59,(61)(62)(63). DNAse is thought to act via degradation of the DNA structure of NETs (48).…”

Section: Figurementioning

confidence: 99%

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

Cools-Lartigue¹,

Spicer²,

McDonald³

et al. 2013

J. Clin. Invest.

1,088

1,025

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The majority of patients with cancer undergo at least one surgical procedure as part of their treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function as the first line of defense during infections, facilitate cancer progression. Neutrophil extracellular traps (NETs) are extracellular neutrophil-derived DNA webs released in response to inflammatory cues that trap and kill invading pathogens. The role of NETs in cancer progression is entirely unknown. We report that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions. In a murine model of infection using cecal ligation and puncture, we demonstrated microvascular NET deposition and consequent trapping of circulating lung carcinoma cells within DNA webs. NET trapping was associated with increased formation of hepatic micrometastases at 48 hours and gross metastatic disease burden at 2 weeks following tumor cell injection. These effects were abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor. These findings implicate NETs in the process of cancer metastasis in the context of systemic infection and identify NETs as potential therapeutic targets. IntroductionCancer remains a devastating cause of mortality worldwide, with the majority of patients dying as a result of metastasis (1-3). Currently, locoregional control in the form of complete oncologic resection remains an essential curative modality for nearly all solid tumors and provides improved overall and disease-free survival (2, 4,5). Control of distant recurrence is predominantly achieved through systemic chemotherapy, with variable results (6-8). However, standard oncologic interventions can have negative consequences. First, manipulation of the primary tumor during surgery is associated with increased numbers of circulating tumor cells (CTCs) (9). Second, infectious complications occur as a result of cancer progression itself, such as bowel obstruction or pneumonia (10, 11), and due to complications of standard cancer treatments, such as chemotherapy and surgery (12)(13)(14).Postsurgical infections occur with alarming frequency, with an incidence approaching 40% in some series (15)(16)(17). Given that the majority of the nearly 2 million patients diagnosed with cancer in 2012 in the United States alone underwent at least one surgical procedure, the tremendous potential burden of infection becomes apparent (18). One disturbing feature of severe infectious complications in patients with cancer is their association with adverse oncologic outcomes independent of the morbidity associated with the infectious insult (14,(19)(20)(21). This phenomenon has been observed across a broad range of malignancies, including lung, esophageal, breast, ovarian, and colorectal cancer, whereby severe postoperative infectious complications, such as pneumonia, peritonitis, and sepsis, are significantly associated wit...

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“…Un estudio publicado en 2009 (28) demostró que su administración intraperitoneal en ratones con melanoma aumenta significativamente el crecimiento del tumor, mediado por la producción de óxido nítrico, así como por una reducción en la respuesta proliferativa de linfocitos T y B. También se ha informado que C60 puede afectar la función de los neutrófilos, disminuyendo la explosión oxidativa, la liberación de trampas extracelulares de neutrófilos (NET, por la sigla en inglés de neutrophil extracellular traps). la expresión de elastasa-2 y la degranulación (29).…”

Section: Fulerenos De Carbono (C60)unclassified

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Gómez-Gallego

Urcuqui-Inchima

Hernández

2016

iatreia

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RESUMENLas nanopartículas (NP) son estructuras con tamaño en la escala nanométrica (1 x 10 -9 m). Por sus características, en los últimos años ha crecido su potencial para usarlas en los campos biotecnológico y biomédico en una amplia gama de aplicaciones, tales como el diagnóstico, la terapia y la medicina regenerativa.El sistema inmunológico es el responsable de la defensa del cuerpo ante organismos patógenos y otros agentes extraños, como las NP, que pueden ser reconocidas por dicho sistema, interactuar con él y modular su función induciendo efectos inmunosupresores o inmunoestimuladores. Las primeras se podrían utilizar como agentes terapéuticos antinflamatorios o para tratar las enfermedades autoinmunes, y las que activan el sistema inmune, como adyuvantes en vacunación o potenciadores de la respuesta inmune en cáncer y otras enfermedades humanas. Sin embargo, su uso en nanomedicina debe estar sujeto a ensayos previos que determinen su efecto en la respuesta inmune antes de aplicarlas a los sistemas biológicos. Por esta razón es importante conocer su composición, tamaño y características superficiales, entre otras propiedades fisicoquímicas, directamente implicadas en los efectos sobre el sistema inmune. Se presenta una visión general de la relación entre las propiedades fisicoquímicas de las NP candidatas para ser usadas en los campos biomédico y biotecnológico y su actividad inmunomoduladora. PALABRAS CLAVEInmunomodulación; Nanomedicina; Nanopartículas SUMMARYImmunomodulating effect of nanoparticles used in nanomedicine Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10 -9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in

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Hydroxylated fullerenes inhibit neutrophil function in fathead minnow (Pimephales promelas Rafinesque, 1820)

Cited by 50 publications

References 49 publications

The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity

The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

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