Hydroxychloroquine ameliorates FGR-associated free fetal haemoglobin evoked fetoplacental vasoconstriction

Brook, Adam; Francis, K Khosho; Hansson, Stefan R.; Crocker, Ian; Brownbill, Paul

doi:10.1016/j.placenta.2017.07.286

Cited by 2 publications

(2 citation statements)

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“…HCQ may improve pregnancy outcomes and provide protective affects through alternative mechanisms, such as inhibiting complement activation [32] or reversing the effects of free fetal haemoglobin on fetoplacental vessels. [57] Further research is needed to determine the safety and mechanism of action of HCQ in placental tissue and how this could be best utilised to potentially improve pregnancy outcomes.…”

Section: A C C E P T E D Mmentioning

confidence: 99%

Effects of hydroxychloroquine on the human placenta—Findings from in vitro experimental data and a systematic review

Scott

Greenwood

Hayes

et al. 2019

Reproductive Toxicology

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Section: A C C E P T E D Mmentioning

confidence: 99%

Effects of hydroxychloroquine on the human placenta—Findings from in vitro experimental data and a systematic review

Scott

Greenwood

Hayes

et al. 2019

Reproductive Toxicology

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“…The demonstration of the beneficial effects of HCQ to prevent maternal and fetal complications has recently opened the way for its use for inflammatory disorders of the placenta with the aim of improving pregnancy outcomes [ 77 , 78 ].…”

Section: Discussionmentioning

confidence: 99%

The Potential Benefit of Hydroxychloroquine in Chronic Placental Inflammation of Unknown Etiology Associated with Adverse Pregnancy Outcomes

et al. 2022

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The placenta is the site of connection between maternal and fetal circulation, and the liaison is established early in pregnancy. A large variety of pregnancy complications such as preterm birth, fetal growth restriction, or pregnancy loss have placental expression and can be accompanied in some cases of acute or chronic identifiable placental inflamatory lesions. Chronic placental inflammatory (CPI) lesions include chronic villitis of unknow etiology (CVUE), chronic intervillositis of unknown etiology, CIUE (also described as chronic histiocytic intervillositis, CHI), and chronic deciduits. Hydroxychloroquine (HCQ) has been prescribed with good results during pregnancy to prevent adverse perinatal outcomes in maternal autoimmune conditions. Its success has paved the way to its use in CPI as CIUE/CHI; however, to date, there are no prospective, informatively designed, controlled studies on its value in these setting. This review aims to explore the potential role of HCQ in CPI of unknown etiology. Ideally, properly designed, probably multicentric studies should be undertaken to fully understand HCQ’s role for prevention of adverse pregnancy outcomes after a chronic placental inflammation.

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Hydroxychloroquine ameliorates FGR-associated free fetal haemoglobin evoked fetoplacental vasoconstriction

Cited by 2 publications

References 0 publications

Effects of hydroxychloroquine on the human placenta—Findings from in vitro experimental data and a systematic review

Effects of hydroxychloroquine on the human placenta—Findings from in vitro experimental data and a systematic review

The Potential Benefit of Hydroxychloroquine in Chronic Placental Inflammation of Unknown Etiology Associated with Adverse Pregnancy Outcomes

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