Hydroxyapatite–collagen–hyaluronic acid composite

Bakoš, Dušan; Soldán, Maroš; Hernández-Fuentes, I.

doi:10.1016/s0142-9612(98)00163-x

Cited by 128 publications

(72 citation statements)

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“…Mixtures of HA with hydroxyapatite and calcium phosphate ceramics for developing composite biomaterials [57][58][59][60][61] resulted in prolonged scaffold stability and reduced degradation rates, but the composite exhibited impaired biological activity. Described here is a novel combination of non-modified HA with natural calcite that produces a biohybrid with unique biological activities.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Calcite Biohybrids as Microenvironment for Stem Cells

2012

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Abstract:A new type of composite 3D biomaterial that provides extracellular cues that govern the differentiation processes of mesenchymal stem cells (MSCs) has been developed. In the present study, we evaluated the chondrogenecity of a biohybrid composed of a calcium carbonate scaffold in its calcite polymorph and hyaluronic acid (HA). The source of the calcite scaffolding is an exoskeleton of a sea barnacle Tetraclita rifotincta (T. rifotincta), Pilsbry (1916). The combination of a calcium carbonate-based bioactive scaffold with a natural polymeric hydrogel is designed to mimic the organic-mineral composite of developing bone by providing a fine-tuned microenvironment. The results indicate that the calcite-HA interface creates a suitable microenvironment for the chondrogenic differentiation of MSCs, and therefore, the biohybrid may provide a tool for tissue-engineered cartilage.

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Section: Immunohistochemical Stainingmentioning

confidence: 99%

Calcite Biohybrids as Microenvironment for Stem Cells

2012

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“…Such syntheses were denoted as ''biologically inspired'' which means they reproduce an ordered pattern and an environment very similar to natural ones [594][595][596]. The biologically inspired biocomposites of collagen and calcium orthophosphates (mainly, apatites) for bone substitute have a long history [29,364,499,[597][598][599][600][601][602][603][604][605][606][607][608][609][610][611][612][613][614][615] and started from the pioneering study by Mittelmeier and Nizard [616], who mixed calcium orthophosphate granules with a collagen web. Such combinations were found to be bioactive, osteoconductive, osteoinductive [29,585,[617][618][619] and, in general, artificial grafts manufactured from this type of the biocomposites are likely to behave similarly to bones and be of more use in surgery than those prepared from any other materials.…”

Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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“…When powder bioceramics are used for bone filling applications, they are usually mixed with a polymeric carrier matrix to avoid migration out of the implant region. Both nonabsorbable [poly(methyl methacrylate), 119 polyethylene, 120 and polysulfone] and biodegradable [poly(lactic acid), 121 polyglycolic acid, collagen, cellulose, and starch 122,123 ] polymeric matrices can be used, even if the nonbiodegradability drastically reduces the HA crystal bioactivity.…”

Section: Drug Delivery Bone Graftsmentioning

confidence: 99%

Evolving application of biomimetic nanostructured hydroxyapatite

Roveri¹,

Iafisco²

2010

NSA

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By mimicking Nature, we can design and synthesize inorganic smart materials that are reactive to biological tissues. These smart materials can be utilized to design innovative thirdgeneration biomaterials, which are able to not only optimize their interaction with biological tissues and environment, but also mimic biogenic materials in their functionalities. The biomedical applications involve increasing the biomimetic levels from chemical composition, structural organization, morphology, mechanical behavior, nanostructure, and bulk and surface chemical-physical properties until the surface becomes bioreactive and stimulates cellular materials. The chemical-physical characteristics of biogenic hydroxyapatites from bone and tooth have been described, in order to point out the elective sides, which are important to reproduce the design of a new biomimetic synthetic hydroxyapatite. This review outlines the evolving applications of biomimetic synthetic calcium phosphates, details the main characteristics of bone and tooth, where the calcium phosphates are present, and discusses the chemical-physical characteristics of biomimetic calcium phosphates, methods of synthesizing them, and some of their biomedical applications.

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Hydroxyapatite–collagen–hyaluronic acid composite

Cited by 128 publications

References 0 publications

Calcite Biohybrids as Microenvironment for Stem Cells

Calcite Biohybrids as Microenvironment for Stem Cells

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Evolving application of biomimetic nanostructured hydroxyapatite

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