Hydroxyapatite Coating on Titanium Alloy Ti-6Al-4V with Electrophoretic Deposition (EPD) for Dental Root Application

Juliadmi, Dian; Fauzi, Vania Raissa; Gunawarman, Gunawarman; Nur, Hadi; Idris, Mohd Hasbullah

doi:10.18517/ijaseit.7.6.3497

Cited by 24 publications

(11 citation statements)

References 50 publications

(95 reference statements)

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“…Since hydroxyapatite is chemically identical to the hydroxyapatite naturally present in bones; hence, it is widely used as a coating material for metal implants for their fixation and regeneration of bones damaged by various types of bone diseases. For the coating of the nHA particles on the surfaces of the bone implants, various methods are used, such as sputtering [127], ion plating, and laser irradiation [128]. However, these physical methods for the deposition of nHA particles on metal surfaces mostly end up with delamination, aggregation, and destruction of the interface.…”

Section: Discussionmentioning

confidence: 99%

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

et al. 2022

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Hydroxyapatite (HA) is a significant constituent of bones or teeth and is widely used as an artificial bone graft. It is often used to replace the lost bones or in reconstructing alveolar bones before dental implantation. HA with biological functions finds its importance in orthopedic surgery and dentistry to increase the local concentration of calcium ions, which activate the growth and differentiation of mesenchymal stem cells (MSC). To make relevant use of HA in bone transplantation, the surfaces of orthopedic and dental implants are frequently coated with nanosized hydroxyapatite (nHA), but its low dispersibility and tendency to form aggregates, the purpose of the surface modification of bone implants is defeated. To overcome these drawbacks and to improve the histocompatibility of bone implants or to use nHA in therapeutic applications of implants in the treatment of bone diseases, various studies suggested the attachment of biomolecules (growth factors) or drugs through chemical bonding at the surface of nHA. The growth factors or drugs bonded physically at the surface of nHA are mostly unstable and burst released immediately. Therefore, reported studies suggested that the surface of nHA needs to be modified through the chemical bonding of biologically active molecules at the surface of bone implants such as proteins, peptides, or naturally occurring polysaccharides to prevent the aggregation of nHA and to get homogenous dispersion of nHA in solution. The role of irradiation in producing bioactive and antibacterial nHA through morphological variations in surfaces of nHA is also summarized by considering internal structures and the formation of reactive oxygen species on irradiation. This mini-review aims to highlight the importance of small molecules such as proteins, peptides, drugs, and photocatalysts in surface property modification of nHA to achieve stable, bioactive, and antibacterial nHA to act as artificial bone implants (scaffolds) in combination with biodegradable polymers.

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Section: Discussionmentioning

confidence: 99%

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

et al. 2022

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“…However, this material can also be synthesized from natural resources included clam shells, egg shells, or animal bones like bovine bone [62][63][64][65][66][67][68]. Hydroxyapatite was chosen as bio-based adhesive material in orthopedic application because of its biocompatibility and bio-activity, since hydroxyapatite is actually a natural matrix of human bone which constructs the bone tissue along with protein and other organic compound [69][70][71][72][73].…”

Section: Sources and Types Of Bio-based Adhesivesmentioning

confidence: 99%

“…Furthermore, as a scaffold, hydroxyapatite demonstrated a good performance since this material can promote new bone remodeling without any serious negative effect. Ultimately, hydroxyapatite can be a good candidate as bone bio-adhesive for utilization in orthopedic applications [69,71,[74][75][76][77][78][79][80][81][82][83]. Summarized information on different bio-based adhesive materials, preparation, and applications is given in Table 1.…”

Section: Sources and Types Of Bio-based Adhesivesmentioning

confidence: 99%

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Nuswantoro

Juliadmi

Mardawati

et al. 2022

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Bone fracture healing involves complex physiological processes that require biological events that are well coordinated. In recent decades, the process of fracture healing has been upheld through various treatments, including bone implants and bio-adhesive utilization. Bio-adhesion can be interpreted as the process in which synthetic or natural materials adhere to body surfaces. Bio-based adhesives have superiority in many value-added applications because of their biocompatibility, biodegradability, and large molecular weight. The increased variety and utilization of bio-based materials with strong adhesion characteristics provide new possibilities in the field of orthopedics in terms of using bio-based adhesives with excellent resorbability, biocompatibility, ease of use, and low immunoreactivity. The aim of this review is to provide comprehensive information and evaluation of the various types of bio-based adhesives used clinically with a specific focus on their application in orthopedics. The main properties of bio-based adhesives, their benefits, and challenges compared with the traditional bio-based materials in orthopedics, as well as the future perspectives in the field, have also been outlined and discussed.

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“…Microstructure and chemical composition of samples were observed with SEM (Scanning Electron Microscope) and energy dispersive X-ray (EDX) [18]. The hardness of Ti-12Cr was measured based on ASTM 384; Standard Test Methods for Knoop and Vickers Hardness Materials [18] with Vicker Hardness Tester. Indentor that used in this testing was a diamond pyramid with angle was 136 0 C. Load value was 9,8 N, and indentation time was 15 minutes.…”

Section: B Observation Of Microstructure and Hardness Testing Of Sammentioning

confidence: 99%

Corrosion Behaviour of Titanium β Type Ti-12Cr in 3% NaCl Solution

Fajri

Gunawarman

Nurbaiti

et al. 2019

Int. J. Adv. Sci. Eng. Inf. Technol.

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Titanium alloy, especially titanium type Ti-12Cr for biomedical application has been a concern of many researchers recently. This titanium has excellent biocompatibility and controllable mechanical properties. Generally, titanium β type contains many alloying elements that lead to a high price. Therefore, it is interesting to develop β type with only one cheap alloying element such as Ti-12Cr that is designed as a low-cost implant material. Initially, Ti-12Cr has been developed, in particular for spinal fixation. Nowadays, the research of Ti-12Cr emphasizes only on mechanical properties. The corrosion behavior of this alloy has not been understood well yet. Therefore, corrosion characteristics of this alloy in any circumstances are necessary to investigate. This paper reports the corrosion behavior of Ti-12Cr in a salted environment using the weight loss method. Ti-12Cr samples were immersed in a 3% NaCl solution for 2, 4, and 6 weeks. Samples consist of Ti-12Cr (as-received), Ti-12Cr (ST) and Ti-12Cr (AT 30 ks). Weight of samples was measured before and after the immersing process using the digital balance. Microstructure and composition of the sample surfaces were examined by using SEM and EDX, respectively. The lowest corrosion rate after exposure for 6 weeks while the highest one is Ti-12Cr (as-received) is Ti-12Cr (AT 30 ks) that is 0,003 mmpy. The microstructure all of the samples shows black spots in the surfaces indicating corrosion has been started to occur on the samples. It was found that the corrosion is due to destruction of the chrome-oxide layer in some weak point as a result of a chemical reaction between the metal (Cr) with Cl-ions. Some oxides are formed on the surface of titanium, as indicated by a significant increment of oxygen content is the corrosive sample surface. This study indicates the corrosion resistance of Ti-12Cr (AT 30 ks) is much better than other materials in this research.

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Hydroxyapatite Coating on Titanium Alloy Ti-6Al-4V with Electrophoretic Deposition (EPD) for Dental Root Application

Cited by 24 publications

References 50 publications

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

Bio-Based Adhesives for Orthopedic Applications: Sources, Preparation, Characterization, Challenges, and Future Perspectives

Corrosion Behaviour of Titanium β Type Ti-12Cr in 3% NaCl Solution

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