Hydroxy acids and retinoids in cosmetics

Ramos‐e‐Silva, Márcia; Hexsel, Dóris; Rutowitsch, M; Zechmeister, Mônica

doi:10.1016/s0738-081x(01)00189-4

Cited by 34 publications

(30 citation statements)

References 22 publications

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“…With age the skin’s natural rejuvenation process slows drastically and the skin becomes thinner, drier, and less elastic (Ramos-E-Silva et al 2001). …”

Section: Introductionmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

400

318

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Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

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“…With age the skin’s natural rejuvenation process slows drastically and the skin becomes thinner, drier, and less elastic (Ramos-E-Silva et al 2001). …”

Section: Introductionmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

400

318

View full text Add to dashboard Cite

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“…Being undifferentiated, fibroblasts express numerous molecules of various biologic systems, provide homogeneous material, and yield reproducible and reliable data because the cell can be continuously grown in culture. Furthermore, it has been well illustrated that the skin is an extremely retinoid-responsive tissue, and skin fibroblasts may have the same mesoblastic origin as the mesenchymal component of the PPF that was presumed defective in CDH (Ramos-e-Silva et al, 2001;Clugston et al, 2007). The main limitation of this cell model is that the initial perturbation associated with CDH occurs at 5 to 7 weeks' gestation, whereas fetal biopsies have been performed at a much later developmental stages, when CDH has already been diagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…To addess this problem, we propose using fetal skin fibroblasts as a model for studying the expression of the different actors of the retinoid pathway. The skin is an extremely retinoid-responsive tissue, and skin fibroblasts have the same mesoblastic origin as the mesenchymal component of the PPF (Ramos-e-Silva et al, 2001;Clugston and Greer, 2007).…”

Section: Introductionmentioning

confidence: 99%

Fetal skin fibroblasts: A cell model for studying the retinoid pathway in congenital diaphragmatic hernia

Goumy

Coste

Marceau

et al. 2010

Birth Defects Research

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“…The natural process of skin rejuvenation slows dramatically and the skin becomes thinner and drier, losing elasticity [4]. Skin aging is influenced by several factors including genetic factors, environmental exposures (ultraviolet radiation (UV), xenobiotics, and stress mechanisms), hormonal changes, and metabolic processes (generation of reactive oxygen species as chemically activated sugars and aldehydes).…”

Section: Introductionmentioning

confidence: 99%

Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

Oliveira

Prado

Bernegossi

et al. 2014

BioMed Research International

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The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLSv = RP-loaded opaque liquid system and TLSv = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. In vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. In vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. The results showed that the incorporation of RP in LCS improved the safety profile of the drug. In vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.

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Hydroxy acids and retinoids in cosmetics

Cited by 34 publications

References 22 publications

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Fetal skin fibroblasts: A cell model for studying the retinoid pathway in congenital diaphragmatic hernia

Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

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