Hydrothermal fabrication of ZSM‐5 zeolites: Biocompatibility, drug delivery property, and bactericidal property

Abstract

The bone graft-associated infection is widely considered in orthopedic surgery, which may lead to implant failure, extensive bone debridement, and increased patient morbidity. In this study, we fabricated ZSM-5 zeolites for drug delivery systems by hydrothermal method. The structure, morphology, biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites were investigated. The ZSM-5 zeolites have mordenite framework inverted-type structure and exhibit the disk-like shape with the diameter of ∼350 nm and thickness of ∼165 nm. The biocompatibility tests indicate that human bone marrow stromal cells spread out well on the surfaces of the ZSM-5 zeolites and proliferate significantly with increasing culture time. As compared with the conventional hydroxyapatite particles, the ZSM-5 zeolites possess greater drug loading efficiency and drug sustained release property because of the ordered micropores, large Brunauer-Emmett-Teller (BET) surface areas, and functional groups. For the gentamicin-loaded ZSM-5 zeolites, the sustained release of gentamicin minimizes significantly bacterial adhesion and prevents biofilm formation against Staphylococcus epidermidis. The excellent biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites suggest that they have great application potentials for treating implant-associated infections.

Particles of vaterite, a metastable CaCO3polymorph, exhibit high biocompatibility for human osteoblasts and endothelial cells and may serve as a biomaterial for rapid bone regeneration

“…The osteoinductivity of vaterite particles was investigated by the osteogenic differentiation of the human osteoblast cell line (MG‐63). After 7, 14, and 21 days, the cells growing on vaterite‐supplemented media were examined for the expression of ALP, an enzyme involved in the degradation of inorganic pyrophosphate, which guarantees a sufficient supply of phosphate for the mineralisation in the osteogenesis process (Guo, Long, Song, et al, ). In vitro ALP is expressed in an early phase of osteogenesis during the matrix synthesis stage (Czekanska, Stoddart, Ralphs, et al, ).…”

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

“…Consequently, extensive research activities have concentrated on the development of carrier materials and delivery theories [1,2,3,4,5,6] that incorporate a controllable release process, high loading efficiency, low toxicity, and excellent biodegradability. Till now, mesoporous inorganic solids, such as zeolites [7,8] and silica [9,10] (pure or functionalized by a postsynthetic modification), biocompatible dendritic macromolecules or polymers [11], and lipids [12] and metal clusters [13,14], have been taken as possible candidates for drug storage. However, these materials suffer from several limitations [7], namely, low drug-loading capacities (<5 wt %), rapid drug release, and toxicity.…”

Physicochemical Properties Affect the Synthesis, Controlled Delivery, Degradation and Pharmacokinetics of Inorganic Nanoporous Materials

“…As an example, Guo et al [148] used tetraethyl orthosilicate, aluminum isopropoxide, tetrapropylammonium hydroxide and distilled water to construct aluminosilicate molecular sieves, referred to as ZSM-5 zeolites. These materials were used to prepare ZSM-5 zeolites with a molar composition of 0.1 Al 2 O 3 :60 SiO 2 :11.5 TPAOH: 1500 H 2 O.…”