Hydrotalcite: A novel and reusable solid catalyst for one-pot synthesis of 3,4-dihydropyrimidinones and mechanistic study under solvent free conditions

Environmentally Friendly and Facile Synthesis of 2-oxo- and Thioxo-1,2,3,4-tetrahydropyrimidines Catalyzed by Formic Acid as a Natural Green and Bio-based Catalyst under Solvent-Free Conditions

“…Conditions Catalyst Entry (Kumar et al, 2007) 24h/84 Room temperature bakers , yeast 1 (Lal et al, 2012) 35 min/84 Solvent-free, 80 °C Hydrotalcite 2 (Litvic et al, 2010) 20 h/81 MeCN, Reflux [Al(H2O)6](BF4)3 3 (Kamal et al, 2007)…”

“…In recent decades, a number of methodologies for the preparation of these compounds have been reported that is including various catalysts such as calcium fluoride (Chitra et al, 2009), copper(II)sulfamate (Liu et al, 2008), baker's yeast (Kumar et al, 2007), hydrotalcite (Lal et al, 2012), hexaaquaaluminium (III) tetrafluoroborate (Litvic et al, 2010), TBAB (Ahmad et al, 2009), copper (II) tetrafluoroborate (Kamal et al, 2007), Copper (II) acetate (Khodja et al, 2014), [Btto][p-TSA] (Zhang et al, 2015), triethylammonium acetate (Attri et al, 2017), p-dodecylbenzenesulfonic acid (Aswin et al, 2014), TMSPTPOSA (Rao Jetti et al, 2017), hierarchical zeolite (Shahid et al, 2017), bismuth(III)nitrate or PPh 3 (Slimi et al, 2016), lanthanum oxide (Kuraitheerthakumaran et al, 2016) and dendrimer-PWA (Safaei-Ghomi et al, 2018). Some of these methodologies have limitations such as difficult work-up, toxic and expensive catalysts, low yields, the use of strongly acidic conditions and long time reactions.…”

A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

“…To date, several improved reaction protocols have been reported for the synthesis of basic DHPMs which include, the direct modification of the classical one-pot Biginelli approach itself, the implementation of novel, but more complex synthetic strategies, the benefits of using microwave heating, the use of a solid-phase method, alternative green solvents or even the nonuse of solvent, etc [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. In this context, the use of reagents and catalysts supported on solid supports has received much attention in recent years because of the obvious simplification of the purification processes together with a drastic decrease in the production of waste and environmental impact [28][29][30][31].…”

Succinic Acid As a Green and Bio-Based Catalyst assisted solvent-free one-pot Biginelli synthesis of biologically active 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives

“…Recently, numerous protocols for the preparation of these compounds that is including various catalysts have been reported calcium fluoride (Chitra et al, 2009), copper(II)sulfamate (Liu et al, 2009), baker's yeast , hydrotalcite (Lal et al, 2012), hexaaquaaluminium (III) tetrafluoroborate (Litvic et al, 2010), TBAB (Ahmad et al, 2009), copper (II) tetrafluoroborate (Kamal et al, 2007), Copper (II) acetate (Khodja et al, 2014), [Btto][p-TSA] (Zhang et al, 2015), triethylammonium acetate (Attri et al, 2017), p-dodecyl-benzenesulfonic acid (Aswin et al, 2014) and TMSPTPOSA (Rao Jetti et al, 2017). Some of the limitations of these methodologies are low yields, toxic organic solvents and catalyst, harsh reaction conditions and expensive materials.…”