Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf

Salih, Enass Y. A.; Julkunen‐Tiitto, Riitta; Luukkanen, Olavi; Fahmi, Mustafa Kamil Mahmoud; Fyhrquist, Pia

doi:10.1016/j.biopha.2021.112264

Cited by 11 publications

(7 citation statements)

References 115 publications

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“…A similar finding was observed by Petric et al [ 21 ] on lambs supplemented by an herbal mixture. Tannin supplementation in the T group shortened the rumen papillae, which agrees with Hill [ 89 ] on Impala grazed on Combretum imberbe with high-tannin content [ 90 ]. This conclusion was confirmed by Brown et al [ 91 ] who noted the atrophy of the rumen papillae in sheep-fed acacia.…”

Section: Discussionsupporting

confidence: 81%

Rumen fermentation and microbiota in Shami goats fed on condensed tannins or herbal mixture

Rabee,

Mohamed M. Ghandour,

Sallam

et al. 2024

BMC Vet Res

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Background Phytochemical compounds can modify the rumen microbiome and improve rumen fermentation. This study evaluated the impact of supplementation with tannin and an herbal mixture containing ginger (Zingiber officinale), garlic (Allium sativum), Artemisia (Artemisia vulgaris), and turmeric (Curcuma longa) on the rumen fermentation and microbiota, and histology of rumen tissue of goats. Eighteen Shami male goats were divided into three groups (n = 6): non-supplemented animals fed the basal diet (C, control); animals fed basal diet and supplemented with condensed tannin (T); and animals fed basal diet and supplemented with herbal mixture (HM). Each animal received a basal diet composed of Alfalfa hay and a concentrate feed mixture. Results Group HM revealed higher (P < 0.05) rumen pH, total volatile fatty acids (VFA), acetic, propionic, isobutyric, butyric, isovaleric, and valeric. Principal Co-ordinate analysis (PCoA) showed that rumen microbial communities in the control group and supplemented groups were distinct. The supplementation increased (P < 0.05) the relative abundances of phylum Bacteroidota and Proteobacteria and declined (P < 0.05) Firmicutes and Fibrobacterota. Additionally, the dominant genus Prevotella and Rikenellaceae RC9 gut group were increased (P < 0.05) and the family Ruminococcaceae was declined (P < 0.05) due to the supplementation. The supplementation decreased (P < 0.05) the archaeal genus Methanobrevibacter and increased (P < 0.05) Candidatus Methanomethylophilus. Tannin supplementation in T group shortened the rumen papillae. Conclusions The results revealed that the herbal mixture might be used to alter the rumen microbiota to improve rumen fermentation.

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Section: Discussionsupporting

confidence: 81%

Rumen fermentation and microbiota in Shami goats fed on condensed tannins or herbal mixture

Rabee,

Mohamed M. Ghandour,

Sallam

et al. 2024

BMC Vet Res

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“…Here we compared the method of extraction to identify and quantify ellagitannins and more especially vescalagin using either methanol or water. Methanol extraction of tannins is currently the reference method as confirmed by the literature, not only with chestnut tannin [ 11 ] but also with several matrices such as wine [ 16 ], grape [ 15 ], fruit [ 19 ] or medicinal plants [ 20 ]. To confirm the interest to revisit the method of extraction of the hydrolysable polyphenols, it would be necessary to investigate if the improvement of the quantification obtained with chestnut tannin will be the same with other matrices analyzed.…”

Section: Resultsmentioning

confidence: 99%

HPLC-DAD optimization of quantification of vescalagin, gallic and ellagic acid in chestnut tannins

Richard-Dazeur,

Jacolot,

Niquet-Léridon

et al. 2023

Heliyon

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“…The leaves are also used for cough. "Dokhan" obtained from the burnt roots and stems of this plant is used as a medicine traditionally [32].…”

Section: Discussionmentioning

confidence: 99%

Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach

Sharma,

Bansal,

Suman

et al. 2023

Innov Biosyst Bioeng

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Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non-structural proteins named nsP2 and nsP4 are important for the replication of virus, so can be an important drug discovery target. Objective. We are aimed to explore the in silico interaction between plant-based compounds (phytocompounds) and specific protein targets, such as nonstructural protein nsP4 and glycoprotein E2 of Sindbis virus (SINV), nsP2 and E2 of Chikungunya virus (CHIKV), and glycoproteins E1 and E2 of Ross River virus (RRV). Methods. A library of phytochemicals from Indian medicinal plants was prepared using databases and converted to 3D structures. Protein structures (nsP2, nsp4, E1, E2) were obtained and refined, followed by molecular docking with AutoDock Vina. Promising ligands were evaluated for properties, cytotoxicity, and mutagenicity, considering drug-likeness and potential issues. Molecular Dynamics simulations assessed complex stability. Results. We analyzed 375 phytocompounds against these targets using molecular docking, modeling, and molecular dynamics for SINV, CHIKV, and Ross River (RRV) virus proteins. Granatin A has been found to successfully bind to the target sites of SINV nsP4, CHIKV E2, and CHIKV nsP2 with binding affinity values of -16.2, -20.6, and -18.6 Kcal/mol respectively. Further, stability of CHIKV E2 – Granatin A complex was done by performing molecular dynamic simulation and the complex was stable at 60ps. Conclusions. This research provides valuable insights into the development of effective antiviral drugs against alphaviruses, emphasizing the importance of natural compounds and their interactions with viral proteins. This study might pave the way for further exploration of these small molecules as effective anti-alphaviral therapeutic agents.

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Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf

Cited by 11 publications

References 115 publications

Rumen fermentation and microbiota in Shami goats fed on condensed tannins or herbal mixture

Rumen fermentation and microbiota in Shami goats fed on condensed tannins or herbal mixture

HPLC-DAD optimization of quantification of vescalagin, gallic and ellagic acid in chestnut tannins

Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach

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