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Cited by 98 publications
(115 citation statements)
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“…[89] Studies of this phenomenon by Labow and Santerre have focused on the ability of macrophage-derived enzymes to facilitate degradation of polyurethanes. [90][91][92][93][94][95] These studies clearly identified the importance of the use of antioxidants in these polymers to inhibit the oxidation process that occurs with the foreign body reaction. The persistence of the foreign body reaction and the fact that it is present at the interface between the tissue and the device for the lifetime of the device, suggests that the oxidation process is continuous, albeit at low levels.…”
Section: Device Failurementioning
confidence: 91%
See 1 more Smart Citation
“…[89] Studies of this phenomenon by Labow and Santerre have focused on the ability of macrophage-derived enzymes to facilitate degradation of polyurethanes. [90][91][92][93][94][95] These studies clearly identified the importance of the use of antioxidants in these polymers to inhibit the oxidation process that occurs with the foreign body reaction. The persistence of the foreign body reaction and the fact that it is present at the interface between the tissue and the device for the lifetime of the device, suggests that the oxidation process is continuous, albeit at low levels.…”
Section: Device Failurementioning
confidence: 91%
“…The soft segment of polyether polyurethanes is known to undergo degradation. [86][87][88][89][90][91][92][93][94][95][96][97][98] This phenomenon will be discussed in the next section.…”
Section: Mediators Of Degradation-mentioning
confidence: 97%
“…Representative samples of the surface (0-100 lm) and in the center (bulk) were dissolved in dimethylacetamide with 0.1% of lithium bromide at 80°C [15,16]. The sample concentration was 3 g/L.…”
Section: Atr-ftir and Gpc Analyses Of Pcu Spacersmentioning
confidence: 99%
“…A relatively new generation of polyurethanes used in medical devices are based on poly(carbonate-urethane)s (PCUs). According to in vitro and early in vivo studies, PCUs exhibit improved resistance to hydrolytic degradation and in vivo stress cracking compared to oligoester based medical grade polyurethanes [17][18][19][20][21][22][23][24]. Furthermore, according to the mechanism of hydrolytic degradation of PCUs [25], a decrease of pH is not observed, which leads to a much lower inflammation of the surrounding tissues.…”
Section: Introductionmentioning
confidence: 99%