Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

Chattopadhyay, Matangini; Kodela, Ravinder; Nath, Niharika; Dastagirzada, Yosef; Velázquez-Martínez, Carlos A.; Boring, Daniel; Kashfi, Khosrow

doi:10.1016/j.bcp.2011.12.018

Cited by 121 publications

(112 citation statements)

References 32 publications

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“…In recent years, SH-ASA has showed strong inhibitory effects on the growth properties of different cancer cells, including human colon, breast, pancreatic, and prostate cancers. [30][31][32] However, SH-NSAIDs, including SH-ASA, have several drawbacks that limit their development as pharmaceuticals. For example, they usually have relatively high half maximal inhibitory concentrations (IC 50 s) and difficulties with water solubility.…”

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confidence: 99%

“…HS-NSAIDs have been reported recently to have potential cancer-controlling bioactivity. [29][30][31][32] Their difficulties in water solubility also limit further development. Nanotechnology provides optimizing strategies when solving the issue of poor water solubility of hydrophobic drugs.…”

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confidence: 99%

“…[2][3][4][5]30,31 In order to gain better therapeutic activity, in the present study, we applied a combination therapy on ovarian cancer cells with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles. Compared to free drugs, the prepared nanoparticles not only retained the cytotoxicity of the two agents on the ES-2 and SKOV3 cells, but they also showed better anticancer ability than either the SH-ASA or Cur nanoparicles alone, suggesting a strong synergistic effect.…”

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confidence: 99%

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Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Zhou¹,

Duan²,

Zeng³

et al. 2015

IJN

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Natural product curcumin (Cur) and H 2 S-releasing prodrug SH-aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified oil-in-water single-emulsion solvent evaporation process. The prepared SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of 122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in water, with high drug-loading capacity and stability. Intriguingly, by treating with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were observed in vitro, and activation of the mitochondrial apoptosis pathway was indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles could have potential clinical advantages for the treatment of ovarian cancer.

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confidence: 99%

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Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Zhou¹,

Duan²,

Zeng³

et al. 2015

IJN

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“…It has been reported that the increased H 2 S production plays a crucial role in cell proliferation and the related angiogenesis in several types of cancer cell lines, such as colonic and ovarian cancers. 18,19) In addition, there are many papers showing that endogenous or exogenous H 2 S modulates cell proliferation and migration in gastric, oral, breast, pancreas, lung or prostate cancer and also leukemia, 12,[20][21][22] whereas, H 2 S promotes and suppresses cancer growth in distinct cells. Thus, the effects of H 2 S on cancers might vary with the tissues, conditions surrounding cancer, the amount of synthesized H 2 S, and so on.…”

Section: Resultsmentioning

confidence: 99%

Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells

Sekiguchi

Sekimoto

Ogura

et al. 2016

Biological & Pharmaceutical Bulletin

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Hydrogen sulfide (H 2 S), the third gasotransmitter, is endogenously generated by certain H 2 S synthesizing enzymes, including cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS) from L-cysteine in the mammalian body. Several studies have shown that endogenous and exogenous H 2 S affects the proliferation of cancer cells, although the effects of H 2 S appear to vary with cell type, being either promotive or suppressive. In the present study, we determined whether endogenously formed H 2 S regulates proliferation in human gastric cancer AGS cells. CSE, but not CBS, was expressed in AGS cells. CSE inhibitors, DL-propargylglycine (PPG) and β-cyano-L-alanine (BCA), significantly suppressed the proliferation of AGS cells in a concentration-dependent manner. CSE inhibitors did not increase lactate dehydrogenase (LDH) release in the same concentration range. The inhibitory effects of PPG and BCA on cell proliferation were reversed by repetitive application of NaHS, a donor of H 2 S. Interestingly, nuclear condensation and fragmentation were detected in AGS cells treated with PPG or BCA. These results suggest that endogenous H 2 S produced by CSE may contribute to the proliferation of gastric cancer AGS cells, most probably through anti-apoptotic actions.

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“…Cyclooxygenase has two isoforms: cyclooxygenase 1 (COX-1) which has an important role in homeostasis, and cyclooxygenase 2 (COX-2) which is induced by inflammatory mediators (12). NSAIDs inhibit COX enzyme and numerous studies have demonstrated their anti-proliferative effects on various cancer cell lines (13)(14)(15)(16)(17)(18)(19). Their mechanism of action is not well understood but COX dependent and independent pathways have been suggested to have an important role in tumor genesis (20).…”

Section: Introductionmentioning

confidence: 99%

Anti-Proliferative Effects of Piroxicam and Nimesulide on A431 Human Squamous Carcinoma Cell Line

2017

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Background: Skin cancer is one of the most common types of cancer worldwide and non-steroidal anti-inflammatory drugs (NSAIDs) have been proposed for prevention and treatment of a variety of cancers. Objectives: In this study we aimed to evaluate the cytotoxic effects of piroxicam (a non-selective cyclooxygenase (COX) inhibitor) and nimesulide (a highly selective COX-2 inhibitor) on A431 human squamous carcinoma cell line. Methods: Squamous carcinoma cell line (A431) was cultured in RPMI medium containing 10% FBS and penicillin-streptomycin at

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Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

Cited by 121 publications

References 32 publications

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells

Anti-Proliferative Effects of Piroxicam and Nimesulide on A431 Human Squamous Carcinoma Cell Line

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