Hydrogen Sulfide Is a Novel Prosecretory Neuromodulator in the Guinea-Pig and Human Colon

Schicho, Rudolf; Krueger, Dagmar; Zeller, Florian; Weyhern, Claus W. Hann von; Frieling, Thomas; Kimura, Hideo; Ishii, Isao; Giorgio, Roberto De; Campi, Barbara; Schemann, Michael

doi:10.1053/j.gastro.2006.08.035

Cited by 197 publications

(239 citation statements)

References 45 publications

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“…Hence, ICC injury is usually associated with injury to the enteric nervous system (Huizinga and White 2008). Schicho et al (2006) have demonstrated that more than 90% of guinea pig and human submucous and myenteric neurons coexpress CSE and CBS. In that study, myenteric ICC were CSE-immunoreactive, demonstrating that ICC may produce H 2 S that acts in an autocrine manner, again suggesting a close correlation between H 2 S and ICC.…”

mentioning

confidence: 99%

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Huang

Tong

et al. 2010

Tohoku J. Exp. Med.

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mentioning

confidence: 99%

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Huang

Tong

et al. 2010

Tohoku J. Exp. Med.

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“…It has been shown that the enzymes responsible for the production of H 2 S are present in the enteric nerves and the myenteric ICCs, 23 both of which can be found in the IAS. 8,24 Inhibition of H 2 S synthesis with PAG + AOAA depressed relaxation responses to EFS and the depression was additive to that of ODQ and therefore independent of cGMP indicating a small role for H 2 S in relaxation of the IAS to EFS.…”

Section: Discussionmentioning

confidence: 99%

Three Gaseous Neurotransmitters, Nitric oxide, Carbon Monoxide, and Hydrogen Sulfide, Are Involved in the Neurogenic Relaxation Responses of the Porcine Internal Anal Sphincter

Folasire

Mills

Sellers

et al. 2015

J Neurogastroenterol Motil

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Background/AimsThe internal anal sphincter (IAS) plays an important role in maintaining continence and a number of neurotransmitters are known to regulate IAS tone. The aim of this study was to determine the relative importance of the neurotransmitters involved in the relaxant and contractile responses of the porcine IAS. MethodsResponses of isolated strips of IAS to electrical field stimulation (EFS) were obtained in the absence and presence of inhibitors of neurotransmitter systems. ResultsContractile responses of the sphincter to EFS were unaffected by the muscarinic receptor antagonist, atropine (1 mM), but were almost completely abolished by the adrenergic neuron blocker guanethidine (10 mM). Contractile responses were also reduced (by 45% at 5 Hz, P < 0.01) following desensitisation of purinergic receptors with α,β-methylene-ATP (10 mM). In the presence of guanethidine, atropine, and α,β-methylene-ATP, the remaining relaxatory responses to EFS were examined. These responses were not altered by the cyclooxygenase inhibitor, indomethacin (5 mM), the vasoactive intestinal polypeptide receptor antagonist, [D-p-Cl-Phe 6 ,Leu 17 ]-vasoactive intestinal peptide (PheLeu-VIP; 100 nM), or the purinoceptor antagonists, 8-phenyltheophyline (P1 receptors) or suramin (P2 receptors). However, relaxation responses were reduced by Nω-nitro-L-arginine (L-NNA; 100 mM), an inhibitor of nitric oxide synthesis (40-50% reduction), zinc protoprophyrin IX (10 mM), an inhibitor of carbon monoxide synthesis (20-40% reduction), and also propargylglycine (30 mM) and aminooxyacetic acid (30 mM), inhibitors of hydrogen sulphide synthesis (15-20% reduction). ConclusionsStimulation of IAS efferent nerves releases excitatory and inhibitory neurotransmitters: noradrenaline is the predominant contractile transmitter with a smaller component from ATP, whilst 3 gases mediate relaxation responses to EFS, with the combined contributions being nitric oxide > carbon monoxide > hydrogen sulfide.

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“…Myenteric interstitial cells of Cajal were CSEimmunoreactive in the guinea-pig and human colon [33] . However, CBS was mainly expressed in the neurons of enteric neuron system and in the mucosa of the colon [31,33,34] . In the presence of L-cysteine, homogenate of rat colonic tissue could generate about 2 nM/min/g protein H2S [35] .…”

Section: Ynthesis Of H2s In the Gastrointestinal Tractmentioning

confidence: 91%

“…And the inhibitor of CBS or CSE could inhibit the H2S generation [26,28] . CSE was found to be mainly expressed in the submucosal and myenteric neurons of the colon [31][32][33][34] , but also found in the circular and longitudinal smooth muscle layers in the rat colon [34] . Myenteric interstitial cells of Cajal were CSEimmunoreactive in the guinea-pig and human colon [33] .…”

Section: Ynthesis Of H2s In the Gastrointestinal Tractmentioning

confidence: 95%

“…CSE was found to be mainly expressed in the submucosal and myenteric neurons of the colon [31][32][33][34] , but also found in the circular and longitudinal smooth muscle layers in the rat colon [34] . Myenteric interstitial cells of Cajal were CSEimmunoreactive in the guinea-pig and human colon [33] . However, CBS was mainly expressed in the neurons of enteric neuron system and in the mucosa of the colon [31,33,34] .…”

Section: Ynthesis Of H2s In the Gastrointestinal Tractmentioning

confidence: 95%

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Synthesis of H2S in the Gastrointestinal Tract

Huang

2015

Journal of Gastroenterology and Hepatology Research

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Hydrogen Sulfide Is a Novel Prosecretory Neuromodulator in the Guinea-Pig and Human Colon

Cited by 197 publications

References 45 publications

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Three Gaseous Neurotransmitters, Nitric oxide, Carbon Monoxide, and Hydrogen Sulfide, Are Involved in the Neurogenic Relaxation Responses of the Porcine Internal Anal Sphincter

Synthesis of H2S in the Gastrointestinal Tract

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