Hydrogen Peroxide and Irradiation of Tumors

Non-Surgical Breast-Conserving Treatment (KORTUC-BCT) Using a New Radiosensitization Method (KORTUC II) for Patients with Stage I or II Breast Cancer

“…Actually, hydrogen peroxide exists in saliva, and sodium hyaluronate exists in subdermal tissue, etc. In fact, it has been approximately 50 years since the arterial injection of 250 mL of 0.12% hydrogen peroxide for radiotherapy of patients with head and neck cancer in 1967 [ 20 ]. Furthermore, KORTUC is an enzyme-targeting therapy, since the target is the anti-oxidative enzymes, peroxidase and catalase, as the main anti-oxidative enzymes in the human body.…”

“…With respect to radiosensitization using hydrogen peroxide, as mentioned above, there have been no reports for approximately these last 50 years following the report of intra-arterial injection of hydrogen peroxide published approximately 50 years ago [ 20 ]. The reason for this may be that the agent could not be precisely injected into the tumor tissue because there was no ultrasonographic equipment or CT then.…”

Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: A new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II)

“…The majority of reports describe intra-arterial infusions of hydrogen peroxide during radiotherapy. This line of investigation appears to have been discontinued because of difficulties with this method of delivering hydrogen peroxide, as well as lack of improved efficacy (35)(36)(37). For example, in the technique of Mallams et al, 250 ml of 0.12% hydrogen peroxide was perfused intra-arterially in about thirty minutes (38).…”

Non-surgical care for locally advanced breast cancer: Radiologically assessed therapeutic outcome of a new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II) with systemic chemotherapy

“…We have already reported favorable efficacy of this new radiosensitizer in vivo and in some preliminary clinical trials (7)(8)(9)(10)(11). Although several studies in the late 1960s and early 1970s investigated the use of hydrogen peroxide in radiotherapy, this line of investigation appears to have been discontinued (22,23). We combined sodium hyaluronate with hydrogen peroxide to preserve oxygen concentrations in tumor tissue for >24 h, while intratumoral injection of hydrogen peroxide alone results in a rapid lowering of oxygen concentrations (unpublished data).…”