Hydrogen peroxide-activatable polymeric prodrug of curcumin for ultrasound imaging and therapy of acute liver failure

Vetha, Berwin Singh Swami; Jung, Eunkyeong; Noh, Joungyoun; Yoo, Donghyuck; Kang, Changsun; Hyeon, Hyejin; Kim, Gi-Wook; Khang, Gilson; Lee, Dongwon

doi:10.1016/j.nano.2018.11.003

Cited by 24 publications

(23 citation statements)

References 42 publications

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“…ALT and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay results of the POC particle treated group showed no ALT induction or damage to the liver tissue ( Figure S6 ). In vivo echogenic performance of POC nanoparticles performed in a study showed aggregation of the particle formulation in the liver which confirms the delivery of the small molecule at the site of inflammation ( Figure S7 ) [ 42 ].…”

Section: Bio Compatibility Of Polyoxalate and Copolyoxalatesmentioning

confidence: 82%

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Vetha

Adam

Aileru

2021

IJMS

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Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers are topics of interest the field of inflammation. This is due to their drug delivery ability and their potential to target reactive oxygen species (ROS) and to accommodate small molecules such as curcumin, vanilline, and p-Hydroxybenzyl alcohol. Their biocompatibility, ultra-size tunable characteristics and bioimaging features are remarkable. In this review we discuss the genesis and concept of oxylate smart polymer-based particles and a few innovative systemic delivery methods that is designed to counteract the inflammation and other aging-associated diseases (AADs). First, we introduce the ROS and its role in human physiology. Second, we discuss the polymers and methods of incorporating small molecule in oxalate backbone and its drug delivery application. Finally, we revealed some novel proof of concepts which were proven effective in disease models and discussed the challenges of oxylate polymers.

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Section: Bio Compatibility Of Polyoxalate and Copolyoxalatesmentioning

confidence: 82%

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Vetha

Adam

Aileru

2021

IJMS

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“…On the other side, nanobiomaterials have their own therapeutic and imaging functions. For instance, H 2 O 2 -responsive polyoxalate [14], the antioxidant polymeric prodrug microparticles: poly(vanillyl alcohol-cooxalate) (PVAX) [12], ROS-responsive poly(ethylene glycol)-b-poly(propylene sulfide) [74], these antioxidant/ anti-inflammatory drug delivery systems show synergistic Fig. 10 a Schematic illustration of the synthesis of POC particle (poly(oxalate-co-curcumin)) as a theranostic agent for ALF.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

“…Reprinted with permission from Ref. [14] 1 3 therapeutic effects in ALF therapy. Magnetic or optical nanomaterials such as SPIOs [205], Au NPs [173], or QDs [203] are utilized for ALF diagnosis, imaging assessment of therapeutic effects, or transplanted stem cell labeling, even multifunctional theranostic platform.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

“…However, poor stability and solubility limit its application in inflammatory diseases [ 218 , 219 ]. Berwin Singh et al designed and synthesized H 2 O 2 -responsive poly(oxalate-co-curcumin) (POC) nanoparticles, in which curcumin was covalently bound to the polymer framework via peroxalate ester [ 14 ]. POC showed excellent anti-inflammatory and highly potent antioxidant activity.…”

Section: Nanobiomaterials As Imaging Agents For Acute Liver Failure Theranosticsmentioning

confidence: 99%

“…Nanomaterial-based drug delivery systems possess outstanding advantages over free therapeutic agents in ALF treatment. Although the use of antioxidants or anti-inflammatory drugs becomes a trend in the treatment of ALF [12][13][14], only limited efficacy can be observed in clinical trials [15,16]. The undesirable therapeutic effect has mainly been ascribed to low accumulation in the damaged liver, rapid drug clearance, difficulty in maintaining the therapy at adequate levels for a long time, and adverse reaction owing to supplementation overdose [17,18].…”

Section: Alf 1 Introductionmentioning

confidence: 99%

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Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Jin

Wang

et al. 2020

Nano-Micro Lett.

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Highlights This review focuses on the therapeutic mechanisms, targeting strategies of various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials for acute liver failure therapy, diagnosis, and imaging. This review provides an outlook on the applications of nanomaterials, especially on the new horizons in acute liver failure therapy, and inspires broader interests across various disciplines. Abstract Acute liver failure (ALF), a fatal clinical disease featured with overwhelming hepatocyte necrosis, is a grand challenge in global health. However, a satisfactory therapeutic option for curing ALF is still absent, other than liver transplantation. Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF. The liver can sequester most of nanoparticles from blood circulation, which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases. Nanobiomaterials can enhance the bioavailability of free drugs, thereby significantly improving the therapeutic effects in ALF. Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells. In addition, stimuli-responsive, optical, or magnetic nanomaterials exhibit great potential in the therapeutical, diagnostic, and imaging applications in ALF. Therefore, therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy, diminish adverse systemic effects, and offer a multifunctional theranostic platform. Nanobiomaterial holds excellent significance and prospects in ALF theranostics. In this review, we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF. We highlight recent developments of diverse nanomedicines for ALF therapy, diagnosis, and imaging. Furthermore, the challenges and future perspectives in the theranostics of ALF are also discussed.

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Dual‐ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy

Liang,

Shen,

Han

et al. 2024

Adv Healthcare Materials

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Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti‐oxidation and anti‐inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL−1), poor tissue‐targeting ability, and rapid oxidative degradation, resulting in poor bioavailability and stability for inflammatory therapy. Here, poly(diselenide‐oxalate‐curcumin) nanoparticle (SeOC‐NP) with dual‐reactive oxygen species (ROS) sensitive chemical moieties (diselenide and peroxalate ester bonds) is fabricated by a one‐step synthetic strategy. The results confirmed that dual‐ROS sensitive chemical moieties endowed SeOC‐NP with the ability of targeted delivery of curcumin and significantly suppress oxidative degradation of curcumin for high‐efficiency inflammatory therapy. In detail, the degradation amount of curcumin for SeOC is about 4‐fold lower than that of free curcumin in an oxidative microenvironment. As a result, SeOC‐NP significantly enhanced the antioxidant activity and anti‐inflammatory efficacy of curcumin in vitro analysis by scavenging intracellular ROS and suppressing the secretion of nitric oxide and pro‐inflammatory cytokines. In mouse colitis models, orally administered SeOC‐NP can remarkably alleviate the symptoms of IBD and maintain the homeostasis of gut microbiota. This work provided a simple and effective strategy to fabricate ROS‐responsive micellar and enhance the oxidation stability of medicine for precise therapeutic inflammation.

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Hydrogen peroxide-activatable polymeric prodrug of curcumin for ultrasound imaging and therapy of acute liver failure

Cited by 24 publications

References 42 publications

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Dual‐ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy

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