Hydrocarbons and Kidney Damage: Potential Use of Neutrophil Gelatinase-Associated Lipocalin and Sister Chromatide Exchange

Lacquaniti, Antonio; Fenga, Concettina; Venuti, Vincenzo Alessio; Pernice, Lucia; Catanzariti, Saverio; Sirna, Giuseppe; Pernice, Francesco; Arena, Adriana; Lupica, Rosaria; Abbate, Carlo; Buemi, Michele

doi:10.1159/000336310

Cited by 12 publications

(6 citation statements)

References 41 publications

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“…49 There are limited comparable occupational cohorts that have measured these biomarkers in workers. 50 To our knowledge, only one previous study in this region has measured kidney injury biomarkers; NGAL levels were increased in 26% of CKD cases in El Salvador. 51 However, it is difficult to compare our population of healthy workers to a population of CKD cases.…”

Section: Discussionmentioning

confidence: 83%

Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers

Laws

Brooks

Amador

et al. 2016

American Journal of Kidney Diseases

104

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Background In Central America, an epidemic of chronic kidney disease of unknown etiology disproportionately affects young, male agricultural workers. Study Design Longitudinal cohort study. Setting & Participants 284 sugarcane workers in seven jobs were recruited from one company in northwestern Nicaragua. Blood and urine samples were collected before and near the end of the six-month harvest season. Predictors Job category (cane cutter, seeder, seed cutter, agrichemical applicator, irrigator, driver, factory worker); self-reported water and electrolyte solution intake. Outcomes & Measurements Change in urinary kidney injury biomarkers normalized to urine creatinine, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), N-acetyl-β-d-glucosaminidase (NAG), and albumin; serum creatinine–based estimated glomerular filtration rate (eGFR). Results Mean eGFR was 113 mL/min/1.73 m2 and less than 5% of workers had albuminuria, field workers had increases in NGAL and IL-18 that were 1.49 (95% CI, 1.06-2.09) and 1.61 (95% CI, 1.12-2.31) times as high, respectively, as in non-field workers. Cane cutters and irrigators had the greatest increase in NGAL during the harvest, while cane cutters and seeders had the greatest increase in IL-18. Consumption of electrolyte solution was associated with lower mean NGAL and NAG among cane cutters and lower mean IL-18 and NAG among seed cutters; however, there was no overall effect of hydration among all workers. On average, workers with the largest increases in NGAL and NAG during the harvest had declines in eGFR of 4.6 (95% CI, −8.2 to −1.0) and 3.1 (95% CI, −6.7 to 0.6) mL/min/1.73 m2, respectively. Limitations Surrogate exposure measure, loss-to-follow-up. Conclusions Results are consistent with the hypothesis that occupational heat stress and volume depletion may be associated with development of kidney disease, and future studies should directly measure these occupational factors. The presence of urine tubular injury markers supports a tubulointerstitial disease that could occur with repeated tubular injury.

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Section: Discussionmentioning

confidence: 83%

Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers

Laws

Brooks

Amador

et al. 2016

American Journal of Kidney Diseases

104

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“…Contrary to popular opinion, alimentary exposure causes a higher rate of human exposure to PAHs than air pollutants do (8). PAH bioaccumulation affects mostly adipose tissue, kidneys, and the liver (9). Smaller amounts may accumulate in the spleen, suprarenal glands, and ovaries.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis

Marinković¹,

Pašalić

Potočki

2013

Biochem Med

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Polycyclic aromatic hydrocarbons (PAHs) are among the most prevalent environmental pollutants and result from the incomplete combustion of hydrocarbons (coal and gasoline, fossil fuel combustion, byproducts of industrial processing, natural emission, cigarette smoking, etc.). The first phase of xenobiotic biotransformation in the PAH metabolism includes activities of cytochrome P450 from the CYP1 family and microsomal epoxide hydrolase. The products of this biotransformation are reactive oxygen species that are transformed in the second phase through the formation of conjugates with glutathione, glucuronate or sulphates. PAH exposure may lead to PAH-DNA adduct formation or induce an inflammatory atherosclerotic plaque phenotype. Several genetic polymorphisms of genes encoded for enzymes involved in PAH biotransformation have been proven to lead to the development of diseases. Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products. Some single nucleotide polymorphisms of the CYP1A1 gene as well as the deletion polymorphisms of GSTT1 and GSTM1 may alter the final specific cellular inflammatory respond. Occupational exposure or conditions from the living environment can contribute to the production of PAH metabolites with adverse effects on human health. The aim of this study was to obtain data on biotransformation and atherosclerosis, as well as data on the gene polymorphisms involved in biotransformation, in order to better study gene expression and further elucidate the interaction between genes and the environment.

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“…PAHs have been known as toxic chemicals and could affect renal function. Previously, PAHs were not found to be associated with renal cancer risk in Americans (Karami et al 2011 ) but associated with kidney damage in Italians (Lacquaniti et al 2012 ). The current findings in the present study were similar to those previous observations showing that PAHs were associated with kidney stones but not failing kidney in American adults.…”

Section: Discussionmentioning

confidence: 97%

Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012

Shiue

2016

Environ Sci Pollut Res

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Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons (PAH) were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols, and pesticides. Therefore, it was aimed to study the relationships of urinary PAH and adult digestive conditions using a large human sample in a national and population-based study in recent years. Data was retrieved from the US National Health and Nutrition Examination Surveys, 2011–2012 including demographics, self-reported health conditions, and urinary PAH. Statistical analyses included chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of 5560 American adults aged 20–80 and included in the statistical analysis, urinary 4-hydroxyphenanthrene was significantly associated with celiac disease (odds ratio (OR) 1.61, 95 % confidence interval (CI) 1.14–2.26, P = 0.009). In addition, urinary 2-hydroxyfluorene (OR 1.35, 95 % CI 1.02–1.78, P = 0.038), 3-hydroxyfluorene (OR 1.35, 95 % CI 1.07–1.70, P = 0.015), 1-hydroxyphenanthrene (OR 1.48, 95 % CI 1.08–2.03, P = 0.017), 1-hydroxypyrene (OR 1.36, 95 % CI 1.05–1.77, P = 0.023), and 2-hydroxynapthalene (OR 1.25, 95 % CI 1.00–1.58, P = 0.054) were significantly associated with kidney stones, although not necessarily failing kidney. There were no statistically significant associations observed in the relationship of urinary PAH and liver problems, although higher levels of PAHs were observed. Urinary PAHs are associated with adult digestive conditions, although the causality cannot be established. From the research perspective, longitudinal monitoring from observational studies and experimental research understanding mechanism would be suggested. Regulation of minimizing PAHs exposure might need to be considered in future health and environmental policies.

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Hydrocarbons and Kidney Damage: Potential Use of Neutrophil Gelatinase-Associated Lipocalin and Sister Chromatide Exchange

Cited by 12 publications

References 41 publications

Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers

Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers

Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis

Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012

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