Hydroa vacciniforme with latent Epstein-Barr virus infection

Ohtsuka, Tsutomu; Okita, Hiroshi; Otsuka, Shun; Yamakage, Akio; Yamazaki, Soji

doi:10.1111/j.1365-2133.2001.04392.x

Cited by 6 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The relationship between the HVLL and HV is nevertheless controversial. Iwatsuki et al 23,26 and others 42,60 showed that both typical and atypical lesions of HV were characterized by the infiltration of EBER-positive T cells, suggesting that they might represent different disease stages across the same spectrum of EBV-associated cutaneous disorders. 26,59 The immunophenotype of HVLL establishes a close relationship with nasal-type extranodal NK/T-cell lymphoma, but this disease usually affects older patients (median age, 50 y) with involvement of the nose, nasal sinuses or the mouth, and the clinical course is highly aggressive with a median overall survival of 8 months, especially for those cases with extranasal involvement and advanced stage disease at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

EBV-associated Cutaneous NK/T-cell Lymphoma

Rodríguez‐Pinilla¹,

Barrionuevo²,

Garcı́a

et al. 2010

American Journal of Surgical Pathology

102

View full text Add to dashboard Cite

We have reviewed clinically, morphologically, and immunophenotypically a series of 14 Epstein-Bar virus (EBV)+ cutaneous natural killer cell (NK)/T-cell lymphoma from Peru. Most (11 out of 14) of these cases fit well into the category of Hydroa vacciniforme-like lymphoma (HVLL), but 3 have a different clinical presentation, without facial involvement. In all 14 cases, skin lesions present in both the sun-exposed and nonexposed areas exhibited a slowly progressive relapsing course, changing from edema, to blistering, ulceration, and final scarring. The immunophenotype had a cytotoxic T or NK-cell lineage. The mean time of disease before admission to hospital was 69 months (range, 6 mo to 31 y). Only 2 patients had fever, hepatosplenomegaly, systemic lymphadenopathy, and a high lactate dehydrodenage (LDH) level at the time of diagnosis, whereas 10 had facial swelling. After treatment, only 4 patients remain alive, although with persistent disease. Ten patients died after a mean follow-up of 11.6 months after the initial diagnosis (range, 1 to 32 mo), because of concurrent infections (4 cases), disease progression (4 patients) or both (2 patients). Endemic Epstein-Bar virus (EBV)-positive cutaneous NK/T-cell lymphoproliferative disorders in childhood and early adulthood are characterized by a protracted clinical course, eventually leading to an aggressive phase characterized by concurrent infections and disease progression.

show abstract

Section: Discussionmentioning

confidence: 99%

EBV-associated Cutaneous NK/T-cell Lymphoma

Rodríguez‐Pinilla¹,

Barrionuevo²,

Garcı́a

et al. 2010

American Journal of Surgical Pathology

102

View full text Add to dashboard Cite

show abstract

“…Although no causation has been identified, the association of Epstein-Barr virus (EBV) infection with HV has been demonstrated previously (e.g. 2,4,5). We describe here four patients with HV.…”

mentioning

confidence: 69%

Antiviral Therapy in Children with Hydroa Vacciniforme

Lysell

Edström²,

Linde³

et al. 2009

Acta Derm Venerol

View full text Add to dashboard Cite

Hydroa vacciniforme is a rare, usually quite severe, photo-dermatosis. Association with Epstein-Barr virus infection and a possibly increased risk of lymphoproliferative malignancy have been demonstrated. We describe here four patients with Epstein-Barr virus-associated hydroa vacciniforme treated with acyclovir/valacyclovir therapy with a good clinical response. The children were reported to have less fatigue, fewer eruptions, less scarring, and increased ability to spend time outdoors without provoking new eruptions. This was also in agreement with clinical observations. However, one patient progressed into an anaplastic lymphoma kinase-1-negative anaplastic large-cell lymphoma in the upper jaw. This was preceded by an increase in EBV viral load. Acyclovir/valacyclovir therapy is a safe treatment. Further studies are required to confirm these results.

show abstract

“…It was first described by Bazin in 1862 and has an estimated prevalence of 0.34 cases per 100 000. It is characterised histopathologically by keratinocyte necrosis with dermal lymphocytic infiltration and clinically by bullae on an erythematous base, which then undergo progressive necrosis to become varioliform scars 4. The disease typically remits spontaneously during adolescence.…”

Section: Commentmentioning

confidence: 99%