Hybrid theranostic microbubbles for ultrasound/photoacoustic imaging guided starvation/low-temperature photothermal/hypoxia-activated synergistic cancer therapy

Abstract

Constructing a theranostic agent for high-contrast multimodality imaging-guided synergistic therapy with long-term tumor retention and minimum systemic side effects still remains a major challenge. Herein, a hybrid microbubble-based theranostic platform...

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

“…GOx has been incorporated into multiple nanomedicines for PTT/ST synergistic treatment as a star molecule. 133–137 Furthermore, multimodal treatments combining PTT/ST with PDT, 98 , 138–140 CDT, 113–116 , 141 chemotherapy, 142–144 gas therapy 145 and immunotherapy 146 , 147 have been developed. Since nanomaterials utilizing GOx were discussed in detail in previous reviews, 46 , 148 we will focus on other compounds altering glucose metabolism introduced in PTT/ST bimodal therapy.…”

BSA-templated synthesis of Ir/Gd bimetallic oxide nanotheranostics for MR/CT imaging-guided photothermal and photodynamic synergistic therapy

“…Clinical or laboratory diagnostic techniques including magnetic resonance (MR), ultrasound (US), near-infrared fluorescence (NIRF), X-ray computed tomography (CT), and photoacoustics (PA) have been successfully combined with chemotherapy, radiotherapy (RT), photothermal therapy (PTT) or photodynamic therapy (PDT) to develop versatile nanotheranostics platforms to boost the effectiveness of diagnosis and treatment. 9–15…”

“…Clinical or laboratory diagnostic techniques including magnetic resonance (MR), ultrasound (US), near-infrared fluorescence (NIRF), X-ray computed tomography (CT), and photoacoustics (PA) have been successfully combined with chemotherapy, radiotherapy (RT), photothermal therapy (PTT) or photodynamic therapy (PDT) to develop versatile nanotheranostics platforms to boost the effectiveness of diagnosis and treatment. [9][10][11][12][13][14][15] Among various therapeutic approaches, PTT and PDT based on near-infrared (NIR) light are highly attractive owing to their non-invasive and penetrating properties, and integrated nanotheranostics systems based on PDT and PTT have been widely developed and explored. 11 However, most of them face problems such as complex synthesis and poor biocompatibility and degradability, which seriously hinder their clinical translation.…”

Nanozyme-laden intelligent macrophage EXPRESS amplifying cancer photothermal-starvation therapy by responsive stimulation

“…Tumor starvation therapy and photothermal therapy could promote and complement each other to achieve better combined treatment effect [ 31 , 33 ]. A series of nanoscale nanozymes, like hollow prussian blue nanoparticles loaded GOx nanosized biocatalyst [ 30 ], heptamethine cyanine dye (Cy7)-conjugated GOx nanoagents [ 33 ], GOx and tirapazamine co-loaded polydopamine doped poly(vinyl alcohol) microbubble [ 34 ], and GOx-conjugated polyaniline nanoplatform [ 35 ], have been reported to achieve combined tumor starvation and photothermal therapy. The GOx-mediated CST can block energy supply to tumor cells, which is beneficial to promote the PTT efficacy in mild temperature, whereas the enzymatic activity of GOx varies with temperature, and exhibits the optimal catalytic properties under PTT at local tumor.…”