Hybrid organoruthenium(II) complexes with thiophene-β-diketo-benzazole ligands: Synthesis, optical properties, CT-DNA interactions and anticancer activity

Ismail, Lamia A.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; Elshaarawy, Reda F.M.; Gad, Emad M.; El-Sayed, W.N.

doi:10.1016/j.jorganchem.2021.121960

“…They have also tested the compounds in the non-tumorigenic BGM and CHO cells, finding high selectivity towards cancer cells over normal cells. Ismail et al [ 23 ] have synthesized two new hybrid half-sandwiched Ru(II) arene complexes of a general formula [ η 6 -( p -cymene)Ru(L)Cl] (where L = 1-(Benzazol-2-yl)-3-(thiophen-2-yl) propane-1,3-dione ), which have exhibited significant inhibitory activity against human breast and lung cancer cells (MCF-7 and A549), finding lower IC 50 values than those of clinical cisplatin drugs. Recently, our group has prepared new compounds of ruthenium (II), neutral and ionic that behave as anticancer agents, especially one of them: [Ru( p -cymene)(2amfol)Cl 2 ] ; , (2amfol = 2-aminephenol) against HeLa and MCF-7 cells [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells

Fuster

¹

,

Moulefera

²

,

Montalbán

³

et al. 2022

Molecules

4

0

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When the [Ru(p-cymene)(μ-Cl)Cl]2 complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained: [Ru(p-cymene)Cl2(2abn)] (I), [Ru(p-cymene)Cl2(4abn)] (II), [Ru(p-cymene)Cl2(2ampy] (III) and [Ru(p-cymene)Cl2(μ-(4ampy)] (IV). All the compounds are characterized by elemental analysis of carbon, hydrogen and nitrogen, proton nuclear magnetic resonance, COSY 1H-1H, high-resolution mass spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of III is reported and compared with the closely related literature of II). The cytotoxicity effects of complexes were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes.

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Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications

Xu,

Lin,

Pan

et al. 2023

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Coordination assembly offers a versatile means to developing advanced materials for various applications. However, current strategies for assembling metal‐organic networks into nanoparticles (NPs) often face challenges such as the use of toxic organic solvents, cytotoxicity because of synthetic organic ligands, and complex synthesis procedures. Herein, we directly assemble metal‐organic networks into NPs using metal ions and polyphenols (i.e., metal‐phenolic networks (MPNs)) in aqueous solutions without templating or seeding agents. We demonstrate the role of buffers (e.g., phosphate buffer) in governing NP formation and the engineering of the NP physicochemical properties (e.g., tunable sizes from 50 to 270 nm) by altering the assembly conditions. A library of MPN NPs is prepared using natural polyphenols and various metal ions. Diverse functional cargos, including anticancer drugs and proteins with different molecular weights and isoelectric points, are readily loaded within the NPs for various applications (e.g., biocatalysis, therapeutic delivery) by direct mixing, without surface modification, owing to the strong affinity of polyphenols to various guest molecules. This study provides insights into the assembly mechanism of metal‐organic complexes into NPs and offers a simple strategy to engineer nanosized materials with desired properties for diverse biotechnological applications.

show abstract

Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications

Xu,

Lin,

Pan

et al. 2023

View full text Add to dashboard Cite

Coordination assembly offers a versatile means to developing advanced materials for various applications. However, current strategies for assembling metal‐organic networks into nanoparticles (NPs) often face challenges such as the use of toxic organic solvents, cytotoxicity because of synthetic organic ligands, and complex synthesis procedures. Herein, we directly assemble metal‐organic networks into NPs using metal ions and polyphenols (i.e., metal‐phenolic networks (MPNs)) in aqueous solutions without templating or seeding agents. We demonstrate the role of buffers (e.g., phosphate buffer) in governing NP formation and the engineering of the NP physicochemical properties (e.g., tunable sizes from 50 to 270 nm) by altering the assembly conditions. A library of MPN NPs is prepared using natural polyphenols and various metal ions. Diverse functional cargos, including anticancer drugs and proteins with different molecular weights and isoelectric points, are readily loaded within the NPs for various applications (e.g., biocatalysis, therapeutic delivery) by direct mixing, without surface modification, owing to the strong affinity of polyphenols to various guest molecules. This study provides insights into the assembly mechanism of metal‐organic complexes into NPs and offers a simple strategy to engineer nanosized materials with desired properties for diverse biotechnological applications.

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Hybrid organoruthenium(II) complexes with thiophene-β-diketo-benzazole ligands: Synthesis, optical properties, CT-DNA interactions and anticancer activity

Cited by 7 publications

References 49 publications

Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells

Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells

Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications

Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications

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