This study examines the feasibility of Laser transmission welding(LTW) of a 100% homo-polypropylene transparent part joined to an absorbent part composed of 15% wt white oak wood fiber reinforced homo-polypropylene doped with 0.2% carbon black in lap-joint configuration. Focus is given to investigating the influence of process parameters, namely laser power, welding speed, stand-off distance, and clamp pressure on the laser welded joints of polypropylene joined to plant-based polypropylene composite and the feasibility of weld strength prediction using Response Surface Method (RSM), Artificial Neural Network (ANN) and Adaptive Neuro-Fuzzy Inference System (ANFIS). Results showed that stand-off distance was the most crucial factor affecting weld strength, followed by welding speed. Laser power and clamp pressure had insignificant effects on weld strength in the design space studied in this paper. The coefficient of determination (R2) was (0.90), (0.93), and (0.99) for the RSM model, the ANN model, and the ANFIS model, respectively. All the prediction models exhibited acceptable mean absolute error percentages and root-mean-square errors. The results suggested a satisfactory performance in predicting weld strength for the specified materials in this study's specified parameter design space. The ANFIS model showed the best predictions, followed by the ANN and RSM models.