2018
DOI: 10.18632/aging.101493 View full text |Buy / Rent full text
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Abstract: Mesenchymal stem cells, a subpopulation of mesenchymal stromal cells (MSCs), are present in the stroma of several tissues. MSC in vitro cultivation for clinical treatments may greatly affect MSC properties. A primary handicap is replicative senescence that impairs MSC functions. Hyaluronan (HA) is present in the extracellular matrix that composes the stem cell niche environment and is under investigation as a key factor for in vitro stem cell growth. We evaluated the effect on MSC cultivation of HA hybrid coop… Show more

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“…These results suggest that hyaluronan-coated surfaces induce PMDSCs into a resting/quiescent state that preserved their stemness properties. Other recent reports have confirmed the ability of hyaluronan to promote adipogenic and chondrogenic differentiation and induce senescence delay (4). Previous studies have demonstrated a crucial function of hyaluronan on stem cell metabolism (5,6).…”
Section: Introductionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…These results suggest that hyaluronan-coated surfaces induce PMDSCs into a resting/quiescent state that preserved their stemness properties. Other recent reports have confirmed the ability of hyaluronan to promote adipogenic and chondrogenic differentiation and induce senescence delay (4). Previous studies have demonstrated a crucial function of hyaluronan on stem cell metabolism (5,6).…”
Section: Introductionmentioning
“…Interestingly, the possible correlation between inflammation, hyaluronan fragmentation, CD44 expression on chondrocytes, cartilage disruption and protective homeostatic tissue remodeling during OA[18, 41, 4446] have already been reported although with contradictory results. In accordance with previous works[19, 20, 24], which revealed the synergistic properties of both low and high ranges of MW for in vitro treatment on human cultured chondrocytes, we used an innovative formulation of HA, consisting in a hybrid complex of combined low (LMW) and high molecular weight (HMW)-HA[24].…”
Section: Discussionmentioning
“…For HA experiments, we used hyaluronic acid hybrid complex commercialized by IBSA Farmaceutici (Italy), (ratio 1:1) with H-HA (MW: 1200 ±100 kDa) and L-HA (MW: 100 ± 10 kDa) prepared as reported[24]. HA stock solution was mixed with culture media and the final concentration of hyaluronan mixture was 0.5%.…”
Section: Methodsmentioning
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“…Besides, the biological properties of HCC have already been tested on several cell cultures used as representative models for tissue regeneration [ 22 24 ]. Recently, HCC has been proved to be effective on cell co-culture models subjected to stressful conditions to mimic injuries [ 25 ]. Furthermore, it is known that HA is the subject of the ROS attack, which leads to changes in its structure modulating oxidative condition [ 26 28 ].…”
Section: Introductionmentioning