Nicola Alessio, Antonietta Stellavato, Tiziana Squillaro, Stefania Del Gaudio, Giovanni Di Bernardo, Gianfranco Peluso, Mario De Rosa, Chiara Schiraldi, Umberto Galderisi
Abstract:Mesenchymal stem cells, a subpopulation of mesenchymal stromal cells (MSCs), are present in the stroma of several tissues. MSC in vitro cultivation for clinical treatments may greatly affect MSC properties. A primary handicap is replicative senescence that impairs MSC functions. Hyaluronan (HA) is present in the extracellular matrix that composes the stem cell niche environment and is under investigation as a key factor for in vitro stem cell growth. We evaluated the effect on MSC cultivation of HA hybrid coop…
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