“…Since its introduction in the market, the use of HA fillers is dramatically changed, moving from the treatments of superficial lines to a total facial aging rehabilitation. Moreover, HA injections, nowadays, are also used for post-surgical corrective procedures, are able to modify muscle contraction (e.g., gummy smile treatment), and so on [17], [18], [19], [20], [21]. HA fillers are the only ones that can be reversed whenever it is needed just injecting HYAL, this confers a really high safety profile to these medical devices and probably this is the reason why, over time, other resorbable substances introduced in the market did not gain the same approval [3], [4].…”