Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells

A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting

“…We previously found a similar phenomenon that modification of the R8-modified carriers with hyaluronic acid resulted in a negatively charged carrier surface, while the cellular uptake activity of R8-modified carriers with or without hyaluronic acid were comparable 28 . As an explanation for this, it is possible that the head group of R8 could be displayed on the RNA aptamer coated carrier-surface, and a part of the R8 could then induce cellular uptake.…”

Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor Agent

“…Next, to make sure the importance of CD44 for cytotoxic activity of Ad-HA/M-β-CyD, we compared its cytotoxic activity in HCT116 cells (CD44 (+)) with that in NIH3T3 cells (CD44 (-)) 32) ( Fig. 5a, b).…”

Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

“…Finally, the HA-modified PL-MANs were collected after centrifugation at 8,000 rpm for 10 min and the unreacted HA was removed. 3,26 In vitro DOX release…”