Hyaluronic acid coated poly-ɛ-caprolactone nanospheres deliver high concentrations of cyclosporine A into the cornea

Yenice, İrem; Mocan, Mehmet Cem; Palaska, Erhan; Bochot, Amélie; Bilensoy, Erem; Vural, İmran; İrkeç, Murat; Hıncal, A. A.

doi:10.1016/j.exer.2008.04.002

Cited by 102 publications

(52 citation statements)

References 29 publications

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“…13 PCL nanoparticles have been used as drugs delivery systems for amphotericin B, 14 indometacin, 15 griseofulvin, 16 tamoxifen, 17 vaccines, 18 and cyclosporine A. 19 In this work, PCL nanoparticles were produced by solvent emulsion evaporation method suitable for encapsulation of hydrophobic drugs like as NPX.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Mello¹,

Ricci-Júnior²

2011

Quím. Nova

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Recebido em 7/6/10; aceito em 10/1/11; publicado na web em 25/3/11 Nanoparticles were produced by solvent emulsification evaporation method with the following characteristics: nanometric size (238 ± 3 nm), narrow polydispersity index (0.11), negative zeta potential (-15.1 mV), good yield of the process (73 ± 1.5%), excellent encapsulation efficiency (81.3 ± 4.2%) and spherical shape. X-rays diffraction demonstrated the loss of drug crystallinity after encapsulation; however, the profile of the diffractograms of the poly-ε-caprolactone (PCL) nanoparticles was kept. Differential scanning calorimetry thermograms, correspondingly, exhibited the loss of drug melting peak and the increasing of the melting point of the PCL nanoparticles, evidencing an interaction drug-polymer. Naproxen release was low and sustained obeying the Higuchi´s kinetic. The results show that nanoparticles are promising sustained release system to the naproxen.

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Section: Introductionmentioning

confidence: 99%

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Mello¹,

Ricci-Júnior²

2011

Quím. Nova

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“…É um composto relativamente seguro, sendo utilizado na medicina estética e medicina regenerativa, e frequentemente proposto como biomaterial para os mais diversos sistemas de base nanotecnológica. Esse material pode ser utilizado no recobrimento de nanoestruturas mais lipofílicas como nanopartículas poliméricas, 136 nanopartículas lipídicas sólidas 137 ou nanoemulsões, 138 bem como constituinte da matriz de nanopartícu-las, inclusive como único polímero formador. 139 A propriedade mais atrativa do ácido hialurônico no que compete ao desenvolvimento de sistemas carreadores de fármacos é a sua capacidade de interagir especificamente com receptores de internalização CD44 e receptor de endocitose de ácido hialurônico (HARE).…”

Section: áCido Hialurônicounclassified

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

et al. 2016

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“…In addition, prednisolone using HA benzyl ester films through ocular delivery provided optimally sustained drug delivery (Hume et al, 1994) while ocular formulation of poly-ε-caprolactone (PCL) nanosphere coated with HA increased bioavailablity (Barbault-Foucher et al, 2002). Recently, HA coated PCL/benzalkonium chloride nanospheres were able to achieve high levels of cyclosporine A (Cy A) in the cornea that was 10-15-fold higher than that achieved with Cy A solution in castor oil (Yenice et al, 2008).…”

Section: Ha In Nonparenteral Deliverymentioning

confidence: 99%

Hyaluronic Acid in Drug Delivery Systems

Jin¹,

Termsarasab²,

Kim³

2010

Journal of Pharmaceutical Investigation

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− Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications including arthritis treatment, wound healing, ocular surgery, and tissue augmentation. Because of its mucoadhesive property and safety, HA has received much attention as a tool for drug delivery system development. It has been used as a drug delivery carrier in both nonparenteral and parenteral routes. The nonparenteral application includes the ocular and nasal delivery systems. On the other hand, its use in parenteral systems has been considered important as in the case of sustained release formulation of protein drugs through subcutaneous injection. Particles and hydrogels by various methods using HA and HA derivatives as well as by conjugation with other polymer have been the focus of many studies. Furthermore, the affinity of HA to the CD44 receptor which is overexpressed in various tumor cells makes HA an important means of cancer targeted drug delivery. Current trends and development of HA as a tool for drug delivery will be outlined in this review.

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Hyaluronic acid coated poly-ɛ-caprolactone nanospheres deliver high concentrations of cyclosporine A into the cornea

Cited by 102 publications

References 29 publications

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

Hyaluronic Acid in Drug Delivery Systems

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