2018
DOI: 10.1590/s2175-97902018000417361
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Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity

Abstract: All-trans retinoic acid (ATRA) has been studied for the treatment of cancer, including leukemia and breast cancer. This work aims to develop nanoemulsions (NE) loaded with a hydrophobic ion pair (HIP) of all-trans retinoic acid (ATRA) and a lipophilic amine, stearylamine (SA), and coated with hyaluronic acid (HA) to enhance anticancer activity and reducing toxicity. Blank NE was prepared by spontaneous emulsification and optimized prior to HIP incorporation. NE-ATRA was electrostatically coated with different … Show more

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Cited by 5 publications
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“…For the various nanoparticulated systems reported, drug loading is usually below 10 % or even 1% (Liu et al., 2020 ). Due to their recognized ability for facilitating the encapsulation of the hydrophobic molecules through the lipid matrix, NE have been used to wrap essential oils and nutrients, and a large number of studies have reported using them to package different types of drugs, such as paclitaxel (Shakhwar et al., 2020 ), curcumin (Prasad et al., 2020 ), and retinoic acid (Tinoco et al., 2018 ), among others.…”
Section: Introductionmentioning
confidence: 99%
“…For the various nanoparticulated systems reported, drug loading is usually below 10 % or even 1% (Liu et al., 2020 ). Due to their recognized ability for facilitating the encapsulation of the hydrophobic molecules through the lipid matrix, NE have been used to wrap essential oils and nutrients, and a large number of studies have reported using them to package different types of drugs, such as paclitaxel (Shakhwar et al., 2020 ), curcumin (Prasad et al., 2020 ), and retinoic acid (Tinoco et al., 2018 ), among others.…”
Section: Introductionmentioning
confidence: 99%