Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies

Vasvani, Shyam; Kulkarni, Pratik; Rawtani, Deepak

doi:10.1016/j.ijbiomac.2019.11.066

Cited by 282 publications

(206 citation statements)

References 171 publications

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“…Thus, due to the beneficial effects in treating knee disorders by direct action in the affected area, magnetic nanoparticles began to be used in the viscosupplementation treatment for osteoarthritis pain [26,27]. Viscosupplementation treatment is a care therapy consisting of repetitive intra-articular injections with hyaluronic acid (HA), this being used to obtain beneficial hydrogels for tissue regeneration, due to its high biocompatibility [4,20,25].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Antoniac¹,

Cernea²,

Petcu³

et al. 2020

Rev. Chim.

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Drug delivery systems enable transportation of drugs in the body, controlling the time, rate or place of the release rendering them ideal for local treatments. When treating joint diseases such as osteoarthritis of the knee the therapeutically substances are given intra-particularly. Magnetic nanoparticles are used so that the solution containing the treatment can be easily directed from the outside with the help of magnets allowing the drug to reach the maximum concentration at the area of interest. Functionalization of nanoparticles is necessary to obtain viscoelastic solutions with optimal physico-chemical and medical properties. This paper presents a superior method of delivering intraarticular hyaluronic acid using iron oxide magnetic nanoparticles (Fe2O3) which were embedded in tetramethylammonium hydroxide (TMOH) and coated using a layer-by-layer technique with hyaluronic acid and inulin. TMOH was chosen for a better dispersion of nanoparticles in the viscoelastic solution, eliminating the risk of agglomerations, hyaluronic acid and inulin being used for medical purposes.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, viscosupplementation with HA can stimulate the synoviocytes and synovial fibroblast to secrete natural hyaluronic acid. It will behave as a lubricant, an elastic substance buffering the effects of different forces that strain the joint [22,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Antoniac¹,

Cernea²,

Petcu³

et al. 2020

Rev. Chim.

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“…New materials based on the blends of HA, collagen, and chitosan can be prepared in several forms. Film-forming properties can be useful for the preparation of wound-healing materials [ 2 , 63 , 64 , 65 , 66 , 67 , 79 , 80 ]. Mechanical properties of such materials can be modified by chemical and physical crosslinking [ 67 , 72 , 73 , 81 , 82 ].…”

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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“…[26] It possesses antifouling properties which reduce bacterial adhesion, [27] but also anti-inflammatory properties which suppress pro-inflammatory cytokines such as TNF-, IL-1, IL-6. [28] Its anti-inflammatory properties could be related to the interactions between HA and CD44, a glycoprotein involved in cell adhesion and migration. Those interactions can regulate the cytokines production and moderate the inflammatory response.…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Those interactions can regulate the cytokines production and moderate the inflammatory response. [28,29] Because of these properties, HA is an efficient agent for treatment of multiple skin and joint inflammatory diseases. [30] Recently, intra-articular injections of HA have been approved for treating degenerative knee arthritis.…”

Section: Polysaccharidesmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies

Cited by 282 publications

References 171 publications

Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Recent Advances in Antiinflammatory Material Design

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