Hyaluronan and its derivatives for ophthalmology: Recent advances and future perspectives

Huerta-Ángeles, Gloria; Nešporová, Kristina

doi:10.1016/j.carbpol.2021.117697

Cited by 26 publications

(11 citation statements)

References 168 publications

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“…103 HA is used in the treatment of dry eye syndrome. 31 HA provides optimal friction and hydration and was also observed to induce the repair of DNA damage in corneal epithelial cells irradiated by UVB in vitro. 104…”

Section: Ha Protection From Dna Damageinduced Senescencementioning

confidence: 99%

“…A mixture of HA and amino acids prevented the H 2 O 2 ‐induced onset of cellular senescence in fibroblasts but not TGF‐β‐invoked senescence 103 . HA is used in the treatment of dry eye syndrome 31 . HA provides optimal friction and hydration and was also observed to induce the repair of DNA damage in corneal epithelial cells irradiated by UVB in vitro 104…”

Section: Proposed Mechanisms Of the Ha Regulation Of Photoagingmentioning

confidence: 99%

“…The lack of clear consensus on the classification of HA based on its MW can sometimes hinder the reproducibility of published data. In a recent review, HA was divided in 5 categories according to its size as (very high MW [vHMW, >5000 kDa], high [HMW, 1000−3000 kDa], medium [MMW, 250-1000 kDa], low [LMW, 10-250 kDa] MW andHA oligomers [oHA, <10 kDa]),31 but usually the categorization into HMW (>1 MDa), LMW (<1 MDa) is sufficient, mainly for the endogenous HA. In more detailed studies the term MMW HA may appear, usually regarding to HA between 300-1000 kDa.…”

mentioning

confidence: 99%

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Hyaluronan: A key player or just a bystander in skin photoaging?

Šínová

Pavlík

Ondrej

et al. 2021

Experimental Dermatology

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Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water‐retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation‐triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.

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Section: Ha Protection From Dna Damageinduced Senescencementioning

confidence: 99%

Section: Proposed Mechanisms Of the Ha Regulation Of Photoagingmentioning

confidence: 99%

mentioning

confidence: 99%

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Hyaluronan: A key player or just a bystander in skin photoaging?

Šínová

Pavlík

Ondrej

et al. 2021

Experimental Dermatology

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“…Therefore, maintaining HA could prevent further diabetic vascular complications and organ damage. 20 …”

Section: Introductionmentioning

confidence: 99%

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

Radwan¹,

El-Kamel²,

Zaki³

et al. 2021

IJN

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Purpose Apatinib (Apa) is a novel anti-vascular endothelial growth factor with the potential to treat diabetic retinopathy (DR); a serious condition leading to visual impairment and blindness. DR treatment relies on invasive techniques associated with various complications. Investigating topical routes for Apa delivery to the posterior eye segment is thus promising but also challenging due to ocular barriers. Hence, the study objective was to develop Apa-loaded bovine serum albumin nanoparticles (Apa-BSA-NPs) coated with hyaluronic acid (HA); a natural polymer possessing unique mucoadhesive and viscoelastic features with the capacity to actively target CD44 positive retinal cells, for topical administration in DR. Methods Apa-BSA-NPs were prepared by desolvation using glutaraldehyde for cross-linking. HA-coated BSA-NPs were also prepared and HA: NPs ratio optimized. Nanoparticles were characterized for colloidal properties, entrapment efficiency (EE%), in vitro drug release and mucoadhesive potential. In vitro cytotoxicity on rabbit corneal epithelial cells (RCE) was assessed using MTT assay, while efficacy was evaluated in vivo in a diabetic rat model by histopathological examination of the retina by light and transmission electron microscopy. Retinal accumulation of fluorescently labeled BSA-NP and HA-BSA-NP was assessed using confocal microscope scanning. Results Apa-HA-BSA-NPs prepared under optimal conditions showed size, PdI and zeta potential: 222.2±3.56 nm, 0.221±0.02 and −37.3±1.8 mV, respectively. High EE% (69±1%), biphasic sustained release profile with an initial burst effect and mucoadhesion was attained. No evidence of cytotoxicity was observed on RCE cells. In vivo histopathological studies on DR rat model revealed alleviated retinal micro- and ultrastructural changes in the topical HA-Apa-BSA-NP treated eyes with normal basement membrane and retinal thickness comparable to normal control and intravitreally injected nanoparticles. Improved retinal accumulation for HA-BSA-NP was also observed by confocal microscopy. Conclusion Findings present HA-Apa-BSA-NPs as a platform for enhanced topical therapy of DR overcoming the devastating ocular complications of the intravitreal route.

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“…HA can be classified into five groups according to its molecular weight: Very high molecular weight (vHMM-HA > 5000 kDa), high molecular weight HA (HMW-HA, 3000-1000 kDa), medium molecular weight HA (MMW-HA, 1000-250 kDa), low molecular weight HA (LMW-HA, 250-10 kDa) and oligosaccharides (<10 kDa) [4]. The molecular size dictates its physiochemical properties, but it also dictates its biological activity [5,6]. In fact, the viscoelastic properties of any preparation (composition) containing native and/or modified HA will be highly influenced by HA concentration, Mw and chemical or physical modification.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

et al. 2021

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Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease. High and low molecular weight HA are currently used in ophthalmology. However, a large portion of the current literature on friction and lubrication addresses articular (joint) cartilage. Therefore, eye drops compositions based on HA and its derivatized forms are extensively characterized providing data on the tribological and mucoadhesive properties. The physiochemical properties are investigated in buffers used commonly in eye drops formulations. The tribological investigation reveals that amphiphilic HA-C12 decreases the friction coefficient. At the same time, the combination of trehalose/HA or HAC12 enhances up to eighty-fold the mucoadhesiveness. Thus, it is predicted a prolonged residence time on the surface of the eye. The incorporation of trehalose enhances the protection of human keratinocytes (HaCaT) cells, as demonstrated in an in-vitro cell-desiccation model. The presence of trehalose increases the friction coefficient. Medium molecular weight HA shows significantly lower friction coefficient than high molecular weight HA. This research represents a first, wide array of features of diverse HA forms for eye drops contributing to increase the knowledge of these preparations. The results here presented also provide valuable information for the design of highly performing HA-formulations addressing specific needs before preclinic.

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Hyaluronan and its derivatives for ophthalmology: Recent advances and future perspectives

Cited by 26 publications

References 168 publications

Hyaluronan: A key player or just a bystander in skin photoaging?

Hyaluronan: A key player or just a bystander in skin photoaging?

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

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