J. Neurosci. Res. volume 86, issue 11, P2432-2440 2008 DOI: 10.1002/jnr.21681 View full text
Chun Yan Zheng, Hai Yan Zhang, Xi Can Tang

Abstract: Mitochondrial dysfunction has been proved to contribute to ischemia-induced brain damage. In this study, which used a rat middle cerebral artery occlusion (MCAO) model, the protective effects of huperzine A (HupA) against mitochondrial dysfunction and brain damage were investigated. MCAO for 45 min followed by 4 hr of reperfusion significantly impaired the activities of mitochondrial respiratory chain enzymes (complex I, complex II-III, and complex IV) and alpha-ketoglutarate dehydrogenase, increased the produ…

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