Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Delivered Using Silk Fibroin and Sericin Composite Hydrogel Promote Wound Healing

Han, Chaoshan; Liu, Feng; Chen, Wenjie; Luo, Wei; Ding, Fengzhi; Lü, Lin; Wu, Chengjie; Li, Yangxin

doi:10.3389/fcvm.2021.713021

Cited by 19 publications

(10 citation statements)

References 73 publications

(92 reference statements)

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“…The results proved notably suppressed inflammation in AT, the proliferation of tendon cells, and prevented extracellular matrix degradation (Fig. 7) [88]. Additionally, MN patch promoted cell migration and angiogenesis by slowly releasing MSCs derived exosomes and penetrating into the deep layer of the skin, presenting a potentially valuable method for repairing diabetic wound in clinical applications [90].…”

Section: Exosomes With New Dosage Formmentioning

confidence: 89%

Native and engineered exosomes for inflammatory disease

Liu

Fan

et al. 2022

Nano Res.

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Exosomes are extracellular vesicles which carry specific molecular information from donor cells and act as an intercellular communication vehicle, which have emerged as a novel cell-free strategy for the treatment of many diseases including inflammatory disease. Recently, rising studies have developed exosome-based strategies for novel inflammation therapy due to their biocompatibility and bioactivity. Researchers not only use native exosomes as therapeutic agents for inflammation, but also strive to make up for the natural defects of exosomes through engineering methods to improve and update the property of exosomes for enhanced therapeutic effects. The engineered exosomes can improve cargo-loading efficiency, targeting ability, stability, etc., to achieve combined and diverse treatment strategies in inflammation diseases. Herein, a comprehensive overview of the recent advances in application studies of native and engineered exosomes as well as the engineered methods is provided. Meanwhile, potential application prospects, possible challenges, and the development of clinical researches of exosome treatment strategy are concluded from plentiful examples, which may be able to provide guidance and suggestions for the future research and application of exosomes.

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Section: Exosomes With New Dosage Formmentioning

confidence: 89%

Native and engineered exosomes for inflammatory disease

Liu

Fan

et al. 2022

Nano Res.

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“…It was shown that silk fibroin (SF) had excellent mechanical properties and silk sericin (SS) induced adhesion and biocompatibility. Human umbilical cord blood MSC-derived exosomes encapsulated in SF-SS hydrogels promoted nerve growth and suppressed the inflammatory response ( Han et al, 2021 ), and we speculate that they have potential in SCI repair.…”

Section: Exosomes Combined With Biomaterials Scaffolds In Spinal Cord...mentioning

confidence: 98%

Exosomes combined with biomaterials in the treatment of spinal cord injury

Zhang

Jiang

et al. 2023

Front. Bioeng. Biotechnol.

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Spinal cord injury (SCI) is a serious and disabling disease with a high mortality rate. It often leads to complete or partial sensory and motor dysfunction and is accompanied by a series of secondary outcomes, such as pressure sores, pulmonary infections, deep vein thrombosis in the lower extremities, urinary tract infections, and autonomic dysfunction. Currently, the main treatments for SCI include surgical decompression, drug therapy, and postoperative rehabilitation. Studies have shown that cell therapy plays a beneficial role in the treatment of SCI. Nonetheless, there is controversy regarding the therapeutic effect of cell transplantation in SCI models. Meanwhile exosomes, as a new therapeutic medium for regenerative medicine, possess the advantages of small size, low immunogenicity, and the ability to cross the blood-spinal cord barrier. Certain studies have shown that stem cell-derived exosomes have anti-inflammatory effects and can play an irreplaceable role in the treatment of SCI. In this case, it is difficult for a single treatment method to play an effective role in the repair of neural tissue after SCI. The combination of biomaterial scaffolds and exosomes can better transfer and fix exosomes to the injury site and improve their survival rate. This paper first reviews the current research status of stem cell-derived exosomes and biomaterial scaffolds in the treatment of SCI respectively, and then describes the application of exosomes combined with biomaterial scaffolds in the treatment of SCI, as well as the challenges and prospects.

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“…Another study explored the feasibility of a composite hydrogel formed from silk fibroin (SF) and silk sericin (SS) due to the excellent mechanical properties of SF, and the cell-adhesion and biocompatibility properties of SS. After encapsulating and delivering UMSC-Exos, SF–SS hydrogels promoted wound healing and angiogenesis [ 130 ]. Additionally, the delivery of platelet-rich plasma exosomes in a composite chitosan–silk hydrogel sponge was found to upregulate collagen synthesis and deposition, as well as angiogenesis, at the wound site in diabetic rat models [ 127 ].…”

Section: Biomedical Exploitation Of Exosomes Delivered In Hydrogelsmentioning

confidence: 99%

Hydrogels for Exosome Delivery in Biomedical Applications

Xie

Guan

Guo

et al. 2022

Gels

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Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structure, hydrogels are highly compatible with extracellular matrices and biological tissues and can be used as both carriers and matrices to encapsulate cellular secretions. As small extracellular vesicles secreted by nearly all mammalian cells to mediate cell–cell interactions, exosomes play very important roles in therapeutic approaches and disease diagnosis. To maintain their biological activity and achieve controlled release, a strategy that embeds exosomes in hydrogels as a composite system has been focused on in recent studies. Therefore, this review aims to provide a thorough overview of the use of composite hydrogels for embedding exosomes in medical applications, including the resources for making hydrogels and the properties of hydrogels, and strategies for their combination with exosomes.

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Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Delivered Using Silk Fibroin and Sericin Composite Hydrogel Promote Wound Healing

Cited by 19 publications

References 73 publications

Native and engineered exosomes for inflammatory disease

Native and engineered exosomes for inflammatory disease

Exosomes combined with biomaterials in the treatment of spinal cord injury

Hydrogels for Exosome Delivery in Biomedical Applications

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