volume 25, issue 1, P77-84 2011
DOI: 10.3233/jad-2011-102145
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Sun-Ho Han, Eun Sun Jung, Ji-Hoon Sohn, Hyun Joo Hong, Hyun Seok Hong, Jong Won Kim, Duk Lyul Na, Manho Kim, Hee Kim, Hee Jin Ha, Young Ho Kim, Namjung Huh, Min Whan Jung, Inhee Mook-Jung et al.

Abstract: Alzheimer's disease (AD) is the fastest growing neurodegenerative disease in the elderly population, and the search for therapeutic targets and diagnostic AD biomarkers is an exigent issue. Because amyloid-β (Aβ) aggregation constitutes the epicenter of AD pathology, Aβ-binding proteins that regulate Aβ aggregation, such as transthyretin (TTR), have attracted much attention. TTR binds to Aβ, prevents its aggregation, and consequently inhibits Aβ-induced cellular toxicity. Decreased TTR levels in cerebrospinal …

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