Human Serum Protein Markers for Gastric Cancer Detection

Fu, Hualin; Cui, Daxiang

doi:10.1007/978-94-024-0951-2_2

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Circulating Proteomic Biomarkers In Early Gc1

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2019

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“…Other potential circulating biomarkers for detecting early-stage GC include M2-pyruvate kinase, a tumor-associated metabolic marker; the adipocytokine leptin as an independent biomarker of intestinal metaplasia; p-53 autoantibody; the cell-cycle-related protein RegIV; the inflammatory signaling molecules olfactomedin 4 and vascular adhesion protein-1 (VAP-1)[29].…”

Section: Circulating Proteomic Biomarkers In Early Gcmentioning

confidence: 99%

Recent advances in gastric cancer early diagnosis

Necula¹,

Matei²,

Dragu³

et al. 2019

WJG

319

210

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Gastric cancer (GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva, stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC.

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Section: Circulating Proteomic Biomarkers In Early Gcmentioning

confidence: 99%