Human schistosomiasis mansoni: Immune responses during acute and chronic phases of the infection

Caldas, Iramaya Rodrigues; Campi-Azevedo, Ana Carolina; Oliveira, Lúcia Fraga Alves; Silveira, Alda Maria Soares; Correa-Oliveira, Rodrigo; Gazzinelli, Giovanni

doi:10.1016/j.actatropica.2008.05.027

Cited by 152 publications

(155 citation statements)

References 90 publications

Supporting

Mentioning

147

Contrasting

Unclassified

Order By: Relevance

“…Previous studies revealed that the predominant immune response to larval and adult schistosome worm antigens appears to be skewed toward the production of Th1 cytokines [43,44]. Although CD4 + T cells have been shown to be crucial for the development of egg-induced granulomas [45,46], there have been conflicting observations on the roles of Th1 and Th2 cells and the cytokines they secrete in the development of the granulomatous response following egg deposition [47].…”

Section: Discussionmentioning

confidence: 95%

Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination

Salem

Attia

Al-Bolkiny

et al. 2010

J Infect Dev Ctries

View full text Add to dashboard Cite

Background: Interleukin (IL)-12 is a potential adjuvant in a variety of diseases including schistosomiasis. The clinical use of IL-12, however, is limited by the toxicity associated with its systemic administration. We have developed a novel delivery system (designated F2 gel matrix) composed of poly-N-acetyl glucosamine that has the dual properties of sustaining the release of proteins (e.g. interleukins) and adjuvant effects. The main aim of this study was to use a mouse model to test whether IL-12 released from F2 gel can induce adjuvant effects in the schistosomiasis setting as compared to those obtained after systemic delivery of IL-12. Methodology: First, we compared the toxicity induced by paracrine (delivered by F2 gel) and systemic IL-12. Second, we compared the induction of cytokines induced by paracrine and systemic IL-12. Third, we compared the adjuvant effects of paracrine and systemic IL-12-based prophylactic vaccination against schistosomiasis using soluble worm antigen preparation (SWAP). Results: IL-12 released from F2 gel did not induce significant toxicity measured by alanine aminotransferase (ALT). We found similar serum levels of IFN-γ, TNF-α and IL-2 after paracrine and systemic IL-12 treatments. We also found that vaccination with F2 gel/SWAP/IL-12 induced higher anti-schistosomal effects than IL-12/SWAP as evidenced by 1) the decrease in the total liver egg counts; 2) the reduction in the granuloma size and fibrotic reaction in the liver; and 3) the amelioration of the liver functions. Conclusion: Collectively, these results indicate that IL-12-F2 gel delivery approach could be considered as a potential strategy for the treatment of schistosomiasis.

show abstract

Section: Discussionmentioning

confidence: 95%

Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination

Salem

Attia

Al-Bolkiny

et al. 2010

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Although TH1 cells elicit cellular immunity against intracellular bacteria and viruses, infection by helminths, including Schistosoma mansoni, induces a TH2 humoral response, accompanied by release of the cytokines Interleukin (IL)-4, IL-5 and IL-13. 3,4 Effector mechanisms of TH2 activation result in acquired immunity through antibody-dependent cellular cytotoxicity mediated by production of IgE antibodies and eosinophils. 3,4 Upstream of the TH2 pathway, IL-10 is implicated in negotiating the balance between TH1 and TH2 immunity, involving a third class of T reg cells.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Effector mechanisms of TH2 activation result in acquired immunity through antibody-dependent cellular cytotoxicity mediated by production of IgE antibodies and eosinophils. 3,4 Upstream of the TH2 pathway, IL-10 is implicated in negotiating the balance between TH1 and TH2 immunity, involving a third class of T reg cells. 5,6 During chronic schistosomiasis infection, IL-10 production also reduces collateral tissue damage and TH2-induced fibrosis in the liver [7][8][9][10] in response to deposition of S. mansoni eggs.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

et al. 2010

View full text Add to dashboard Cite

Interleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thoroughly explored in schistosomiasis-endemic populations. Three atopyrelated IL10 promoter polymorphisms (rs1800896, rs1800871 and rs1800872), complemented by six tagging single-nucleotide polymorphisms (SNPs), were genotyped in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area in Brazil. Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg counts, indicating burden of infection reflecting effectiveness of schistosomiasis host immunity, were performed using family-based transmission disequilibrium tests for quantitative traits (QTDTs). Alleles A, T and A at the three promoter SNPs rs1800896, rs1800871 and rs1800872 were associated with high tIgE levels in the same direction as in atopy populations (P ¼ 0.0008, 0.026 and 0.045), but not with egg counts. IL10 promoter polymorphisms appear to influence non-specific tIgE levels, but not schistosomiasis-specific immunity. The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P ¼ 0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection.

show abstract

“…[13][14][15][16] The symptoms in nonimmune hosts vary widely. 17,18 Some non-immune subjects develop Katayama syndrome, whereas others remain (virtually) asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

The Immune Response to Schistosome Antigens in Formerly Infected Travelers

Soonawala¹,

Geerts²,

Mos³

et al. 2011

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Human schistosomiasis mansoni: Immune responses during acute and chronic phases of the infection

Cited by 152 publications

References 90 publications

Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination

Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

The Immune Response to Schistosome Antigens in Formerly Infected Travelers

Contact Info

Product

Resources

About