Human Response to Controlled Levels of Sulfur Dioxide

Andersen, Ib; Lundqvist, Gunnar; Jensen, Poul; Proctor, Donald F.

doi:10.1080/00039896.1974.10666429

Cited by 160 publications

(55 citation statements)

References 11 publications

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“…Forced expiratory vital capacity (FVC), forced expiratory volume in the first seeond after maximal inspiration (FEVl.o), and forced expiratory flow during exhalation of the middle part of FVC (FEF,,-,,) were measured with a single breath instrument (Vitalographa, Buckingham, United Kingdom). These techniques have been described in detail earlier (5,6,7). Functional residual capacity and airway resistance were measured in a whole-body plethysmograph (Mercury) (13,14).…”

Section: Physiological Measurerne1ltsmentioning

confidence: 99%

Human response to controlled levels of toluene in six-hour exposures.

Andersen¹,

Lundqvist²,

Mølhave³

et al. 1983

Scand J Work Environ Health

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119

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Section: Physiological Measurerne1ltsmentioning

confidence: 99%

Human response to controlled levels of toluene in six-hour exposures.

Andersen¹,

Lundqvist²,

Mølhave³

et al. 1983

Scand J Work Environ Health

Self Cite

119

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“…Our data suggest a possible leftward shift in the exposure-response curve in some of our subjects. Possible mechanisms for the reduction in NMC include include inhibition of ciliary beating, altered viscoelastic properties or reductions in airway surface fluid (13,22). In human studies, few stimuli other than extreme dehydration markedly inhibit NMC (11).…”

Section: Resultsmentioning

confidence: 99%

“…Alterations in particle clearance have been used to characterize agent toxicity in animal studies (12). Twenty years ago, Anderson et al (13) noted anecdotally that controlled SO2 exposure caused the greatest inhibition of NMC in the human subjects who showed the greatest S02-induced nasal symptoms. These findings suggested the broad hypothesis that subjects reporting increased symptoms with exposure to an irritant might have inhibition of NMC.…”

mentioning

confidence: 99%

Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance.

Bascom

Kesavanathan

Fitzgerald

et al. 1995

Environ Health Perspect

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Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS. Images Figure 1. Figure 2. Figure 3. Figure 4.

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“…The saccharine test can be used to evaluate air pollution. Hyperbaric oxygen slows cilia, as does high altitude [17].…”

Section: Viscosity Therapymentioning

confidence: 99%

Mucociliary Clearance: Measures and Therapies

Grossan¹

2017

Otolaryngol

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Mucociliary Clearance can be measured clinically with the Saccharine Test in the sino-nasal system. When clearance is slow, treat mucus viscosity and slow ciliary beat frequency. Chronic sinusitis and bronchitis are often due to poor MCC. Therapy to upper or lower respiratory system benefits both.Therapy for Mucociliary Clearance includes proteolytic enzymes to reduce mucus viscosity, vibrations for improving ciliary beat frequency, irrigation with Locke-Ringer's solution for cilia frequency, glucosteroids and surfactants.

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Human Response to Controlled Levels of Sulfur Dioxide

Cited by 160 publications

References 11 publications

Human response to controlled levels of toluene in six-hour exposures.

Human response to controlled levels of toluene in six-hour exposures.

Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance.

Mucociliary Clearance: Measures and Therapies

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