Human Prolactin Stimulates Estrogen Production by Feminizing Adrenal Neoplastic Cells

Fs, Fang; Furuhashi, N; Gómez, Oscar

doi:10.3181/00379727-157-40012

Cited by 5 publications

(1 citation statement)

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“…Thus, it can be assumed that reserpine has no direct action on the adrenal gland but does act as a stimulator for ACTH. Reserpine also stimulates prolactin (21,22), and it was reported that human prolactin rather than ACTH stimulated estrogen production, especially estradiol, by feminizing adrenal neoplastic cells (23). This finding indicates,…”

Section: Discussionsupporting

confidence: 61%

Effect of acth on adrenal estrogens.

Higashi

Aizawa

1980

Jpn.J.Pharmacol

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Abstract-Tissue levels of rat adrenal estrogens during the estrous cycle were determined by radioimmunoassay, and effect of ACTH on the adrenal estrogen levels was examined. The levels of estrone and estradiol in proestrus were 2.75+0.61 pg/mg tissue and 1.0± 0.19 pg/mg tissue (mean i SE), respectively. The higher level of estrone but not of estradiol was inclined to appear in proestrus rather than in other phases. Injection of 250 IU/kg of a1-24-ACTH significantly increased the estrone level at 15 and 30 min, and estradiol at 15 min. Administration of reserpine, which was used as the ACTH releaser, produced an increase in the estrone level but did not change the estradiol level. While dexamethasone injection decreased the estrone level significantly at 8 hours after the treatment, the level of estradiol remained unchanged. Hypophysectomy produced a considerable decrease in both steroid levels, particularly estrone. These results indicate that the major estrogen in the rat adrenal gland is estrone and that the level is regulated by hypophyseal ACTH.It has been reported that the plasma or urinary estrogen level remained unchanged in ovariectomized and postmenopausal women, and also that the level increased in subjects with adrenocortical tumor or hyperplasia. In addition, it has been reported that estrogens were produced in adrenal glands besides the ovary, on the basis of the increase of plasma or urinary estrogens with ACTH treatment and decreases seen with dexamethasone treatment (1-5).However, a distinct function of the rat adrenal estrogens has not been clarified. Our study was carried out to determine the level of estrogens in rat adrenal gland during estrous cycle.The interaction between ACTH and adrenal estrogens was also examined using reserpine as the ACTH releaser and both dexamethasone injection and hypophysectomy as ACTH depressor, in order to provide more information on the rat species. MATERIALS AND METHODSAdult, female, Wistar rats weighing 200 g, were housed in a room with controlled temperature (24+1°C) and light (from 6:30 a.m. to 6:30 p.m.). Food and water were given freely. Rats with 3-4 successive regular 4-day estrous cycle were used, and were decapitated at 11:00 a.m., in all the experiments. Rats were used for 48 hr after hypophy sectomy by the external auditory canal method, under ether anesthesia. There were 10 rats per group in all the experiments.After a1-24-ACTH (Daiichi Pharmaceutical Co. Ltd.) had been given s.c., in a dose of 250 IU/kg, dissolved in physiological saline, the rats were sacrificed at 15, 30, and 60 min with minimum disturbance. Dexamethasone phosphate (Sankyo Co. Ltd.) was also given s.c. in a dose of 100 ucg/kg, and the rats were sacrificed at 2, 4, 8, and 24 hr after adminis

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Section: Discussionsupporting

confidence: 61%

Effect of acth on adrenal estrogens.

Higashi

Aizawa

1980

Jpn.J.Pharmacol

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Effect of ACTH on Adrenal Estrogens

Higashi¹,

Aizawa²

1980

Japanese Journal of Pharmacology

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Prolonged Galactorrhoea in a 6‐year‐old Girl With Isosexual Precocious Puberty Due to a Feminizing Adrenal Tumour

Drop

Bruining

Visser

et al. 1981

Clinical Endocrinology

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A large cystic adrenal carcinoma was removed in toto from a 6 1/2-year-old girl with isosexual precocious puberty treated with cyproterone-acetate. Immediately following surgery, sever galactorrhoea developed, but was successfully treated with bromocriptine. The tumour fluid and pre-operative plasma samples contained highly elevated levels of both oestrogens and androgens. In addition prolactin values were high. One year after adrenalectomy all plasma hormonal values were normal for age, but galactorrhoea could still be elicited. The prolonged galactorrhoea is most likely the result of excessive oestrogen 'priming', whereas the hyperprolactinaemic effect of cyproterone acetate therapy remains uncertain.

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Human Prolactin Stimulates Estrogen Production by Feminizing Adrenal Neoplastic Cells

Cited by 5 publications

References 0 publications

Effect of acth on adrenal estrogens.

Effect of acth on adrenal estrogens.

Effect of ACTH on Adrenal Estrogens

Prolonged Galactorrhoea in a 6‐year‐old Girl With Isosexual Precocious Puberty Due to a Feminizing Adrenal Tumour

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