Human Placenta Blood Flow During Early Gestation With Pseudocontinuous Arterial Spin Labeling MRI

Liu, Dapeng; Shao, Xingfeng; Danyalov, Alibek; Chanlaw, Teresa; Masamed, Rinat; Wang, Danny J.J.; Janzen, Carla; Devaskar, Sherin U.; Sung, Kyunghyun

doi:10.1002/jmri.26944

Cited by 27 publications

(22 citation statements)

References 43 publications

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“…Thus far, few studies have investigated the relation between perfusion and GA, showing opposite trends in normal 20,39 and abnormal 19 pregnancies. Recently, Liu et al showed perfusion‐related image parameters for ischemic placental disease were significantly decreased from normal pregnancy during early gestation 40 . The relation between perfusion and GA in women with normal and abnormal pregnancies should be further investigated in future studies with larger subject numbers.…”

Section: Discussionmentioning

confidence: 97%

Systematic evaluation of velocity‐selective arterial spin labeling settings for placental perfusion measurement

Harteveld

Hutter

Franklin

et al. 2020

Magnetic Resonance in Med

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Purpose Placental function is key for successful human pregnancies. Perfusion may be a sensitive marker for the in vivo assessment of placental function. Arterial spin labeling (ASL) MRI enables noninvasive measurement of tissue perfusion and it was recently suggested that ASL with velocity‐selective (VS) labeling could be advantageous in the placenta. We systematically evaluated essential VS‐ASL sequence parameters to determine optimal settings for efficient placental perfusion measurements. Methods Eleven pregnant women were scanned at 3T using VS‐ASL with 2D multislice echo planar imaging (EPI)‐readout. One reference VS‐ASL scan was acquired in all subjects; within subgroups the following parameters were systematically varied: cutoff velocity, velocity encoding direction, and inflow time. Visual evaluation and region of interest analyses were performed to compare perfusion signal differences between acquisitions. Results In all subjects, a perfusion pattern with clear hyperintense focal regions was observed. Perfusion signal decreased with inflow time and cutoff velocity. Subject‐specific dependence on velocity encoding direction was observed. High temporal signal‐to‐noise ratios with high contrast on the perfusion images between the hyperintense regions and placental tissue were seen at ~1.6 cm/s cutoff velocity and ~1000 ms inflow time. Evaluation of measurements at multiple inflow times revealed differences in blood flow dynamics between placental regions. Conclusion Placental perfusion measurements are feasible at 3T using VS‐ASL with 2D multislice EPI‐readout. A clear dependence of perfusion signal on VS labeling parameters and inflow time was demonstrated. Whereas multiple parameter combinations may advance the interpretation of placental circulation dynamics, this study provides a basis to select an effective set of parameters for the observation of placenta perfusion natural history and its potential pathological changes.

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Section: Discussionmentioning

confidence: 97%

Systematic evaluation of velocity‐selective arterial spin labeling settings for placental perfusion measurement

Harteveld

Hutter

Franklin

et al. 2020

Magnetic Resonance in Med

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“…Magnetic resonance imaging (MRI) is currently indicated in certain maternal conditions such as appendicitis, pulmonary embolism, renal colic, and trauma and provides excellent prospects for translational research 2 – 6 . MRI of hypoperfusion has been shown to be a marker of intrauterine growth restriction 7 and recent advances in pulse sequence design may enable a broader dissemination of placental perfusion MRI for clinical studies and diagnosis 8 . MRI was also successfully applied to investigate pregnancy in rodent models including dynamic contrast-enhanced MRI 9 – 11 , arterial spin labeling of placental perfusion 12 , diffusion MR of placental compartmental flow dynamics 13 , or blood/tissue oxygen level dependent (BOLD/TOLD) MRI of hemoglobin oxygenation 14 .…”

Section: Introductionmentioning

confidence: 99%

Phenotyping placental oxygenation in Lgals1 deficient mice using 19F MRI

Boehm‐Sturm

Mueller

Freitag

et al. 2021

Sci Rep

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Placental hypoperfusion and hypoxia are key drivers in complications during fetal development such as fetal growth restriction and preeclampsia. In order to study the mechanisms of disease in mouse models, the development of quantitative biomarkers of placental hypoxia is a prerequisite. The goal of this exploratory study was to establish a technique to noninvasively characterize placental partial pressure of oxygen (PO2) in vivo in the Lgals1 (lectin, galactoside-binding, soluble, 1) deficient mouse model of preeclampsia using fluorine magnetic resonance imaging. We hypothesized a decrease in placental oxygenation in knockout mice. Wildtype and knockout animals received fluorescently labeled perfluoro-5-crown-15-ether nanoemulsion i.v. on day E14-15 during pregnancy. Placental PO2 was assessed via calibrated 19F MRI saturation recovery T1 mapping. A gas challenge with varying levels of oxygen in breathing air (30%, 60% and 100% O2) was used to validate that changes in oxygenation can be detected in freely breathing, anesthetized animals. At the end of the experiment, fluorophore-coupled lectin was injected i.v. to label the vasculature for histology. Differences in PO2 between breathing conditions and genotype were statistically analyzed with linear mixed-effects modeling. As expected, a significant increase in PO2 with increasing oxygen in breathing air was found. PO2 in Lgals1 knockout animals was decreased but this effect was only present at 30% oxygen in breathing air, not at 60% and 100%. Histological examinations showed crossing of the perfluorocarbon nanoemulsion to the fetal blood pool but the dominating contribution of 19F MR signal is estimated at > 70% from maternal plasma based on volume fraction measurements of previous studies. These results show for the first time that 19F MRI can characterize oxygenation in mouse models of placental malfunction.

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“…MRI is a promising technique for fetal and placental imaging because it provides excellent soft-tissue contrast, functional imaging, and no ionizing radiation [ 7 , 8 ]. However, motion in the uterus during MRI still remains one of the major limiting factors for functional placenta and fetal imaging [ 9 , 10 ] as MRI is sensitive to motion artifacts due to a long acquisition time. To date, there is a limited understanding of the uterine motion, particularly in early gestation, and characterization of the uterine motion would be important to allow developing strategies to minimize motion-related MRI artifacts.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Uterine Motion in Early Gestation Using MRI-Based Motion Tracking

Martin

Janzen

et al. 2020

Diagnostics

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Magnetic resonance imaging (MRI) is a promising non-invasive imaging technique that can be safely used to study placental development and function. However, studies of the human placenta performed by MRI are limited by uterine motion and motion in the uterus during MRI remains one of the major limiting factors. Here, we aimed to investigate the characterization of uterine activity during MRI in the second trimester of pregnancy using MRI-based motion tracking. In total, 46 pregnant women were scanned twice (first scan between 14 and 18 weeks and second scan between 19 and 24 weeks), and 20 pregnant subjects underwent a single MRI between 14 and 18 weeks GA, resulting in 112 MRI scans. An MRI-based algorithm was used to track uterine motion in the superior-inferior and left-right directions. Uterine contraction and maternal motion cases were separated by the experts, and unpaired Wilcoxon tests were performed within the groups of gestational age (GA), fetal sex, and placental location in terms of the overall intensity measures of the uterine activity. In total, 22.3% of cases had uterine contraction during MRI, which increased from 18.6% at 14–18 weeks to 26.4% at 19–24 weeks GA. The dominant direction of the uterine contraction and maternal motion was the superior to the inferior direction during early gestation.

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Human Placenta Blood Flow During Early Gestation With Pseudocontinuous Arterial Spin Labeling MRI

Cited by 27 publications

References 43 publications

Systematic evaluation of velocity‐selective arterial spin labeling settings for placental perfusion measurement

Systematic evaluation of velocity‐selective arterial spin labeling settings for placental perfusion measurement

Phenotyping placental oxygenation in Lgals1 deficient mice using 19F MRI

Characterization of Uterine Motion in Early Gestation Using MRI-Based Motion Tracking

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