Human Pharmacology and Abuse Potential of the Analgesic Buprenorphine

The association between outpatient buprenorphine detoxification duration and clinical treatment outcomes: A review

“…In general, buprenorphine appeared to produce a relatively mild withdrawal syndrome compared to the withdrawal expected following detoxification using methadone or clonidine. This is consistent with the literature on buprenorphine withdrawal (Bickel et al, 1988a; Bullingham et al, 1980; Fudala et al, 1990; Hambrook and Rance, 1976; Jasinski et al, 1978). Review of these studies suggests several potential areas for future research.…”

Outpatient Opiate Detoxification Treatment with Buprenorphine

“…They also seemed to tolerate their withdrawal symptoms well. This experience agrees with the observation of Jasinski et al [4]. Sleep disturbances occurred rarely: Patients reported in 20% (n = 7) that they had sleeping problems that persisted for more than 2 nights.…”

Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers

“…Both preparations produced mild to moderate increases in positive subject ratings, indicating some abuse potential. However, the finding in this study of a relatively flat dose-response function and a slow time to peak effect in response to SL administration are features consistent with findings in other studies, and suggests a lower abuse potential of both buprenorphine and buprenorphine/naloxone when given sublingually compared to parenteral administration (Jasinski et al 1978, Lewis 1985, Weinhold et al 1992, Comer and Collins 2002). …”