Human papillomavirus vaccination and cervical cancer risk

Rahangdale, Lisa; Mungo, Chemtai; O’Connor, Siobhán; Chibwesha, Carla J.; Brewer, Noel T.

doi:10.1136/bmj-2022-070115

Cited by 64 publications

(38 citation statements)

References 67 publications

(129 reference statements)

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“…6 Recent human papillomavirus vaccination and increasing screening are effective strategies to reduce the incidence of CC, but not widely accepted due to perceived high cost. 7,8 Therefore, it is still necessary to explore more novel effective targets for treating against CC.…”

Section: Introductionmentioning

confidence: 99%

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Liu,

Xie,

et al. 2024

The FASEB Journal

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BackgroundCervical cancer (CC), closely linked to persistent human papillomavirus infection, represents a major health problem for women worldwide. The objective of this study is to elucidate KIF23's role in the development of CC and its regulatory mechanism.MethodsThe bioinformatics methods were utilized to extract pyroptosis‐associated differentially expressed genes (DEGs) and pivot genes from the GSE9750 and GSE63678 datasets, followed by immune infiltration analysis and quantification of these genes' expression. The effects of kinesin family member 23 (KIF23) were verified through functional experiments in vitro and a mouse xenograft model. The NLPR3 activator, nigericin, was applied for further analyzing the potential regulatory mechanism of KIF23 in CC.ResultsA total of 8 pyroptosis‐related DEGs were screened out, among which 4 candidate core genes were identified as candidate hub genes and confirmed upregulation in CC tissues and cells. These genes respectively showed a positive correlation with the infiltration of distinct immune cells or tumor purity. Downregulation of KIF23 could suppress the proliferation, migration, and invasion abilities in CC cells and tumorigenesis through enhancing pyroptosis. Conversely, KIF23 overexpression accelerated the malignant phenotypes of CC cells and inhibited pyroptosis activation, which was blocked by nigericin treatment.ConclusionsKIF23 may play an oncogenic role in CC progression via inhibition of the NLRP3‐mediated pyroptosis pathway.

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Section: Introductionmentioning

confidence: 99%

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Liu,

Xie,

et al. 2024

The FASEB Journal

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“…Condyloma acuminatum (CA) is a benign growth that often occurs in the genitals and anus and is usually caused by human papillomavirus (HPV) infection mainly through sexual transmission. More than 90% of cases of CA are caused by low-risk (LR) HPV ( Zhou et al, 2019 ; Lu et al, 2020 ), while high-risk (HR) HPV infection is closely related to cervical cancers and oropharyngeal cancers ( Rahangdale et al, 2022 ). Notably researchers pay much attention to the pathogenesis of HR-HPV infection in cancer, which reveals mechanisms of the interaction between HPVs and oncogenes or tumor suppressor genes ( Oyouni, 2023 ).…”

Section: Introdutionmentioning

confidence: 99%

Alteration of RNA m6A methylation mediates aberrant RNA binding protein expression and alternative splicing in condyloma acuminatum

Liu,

Xie,

Wang

et al. 2024

PeerJ

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Background Condyloma acuminatum (CA) is caused by low-risk human papillomavirus, and is characterized by high recurrence after treatment. The RNA modification N6-methyladenosine (m6A) plays an important role during diverse viral infections, including high-risk HPV infection in cervical cancer. However, it is unclear whether low-risk HPV infection changes the RNA m6A methylation in CA. Methods High-throughputm6A-sequencing was performed to profile the transcriptome-wide mRNA modifications of CA tissues infected by LR-HPVs and the paired normal tissues from CA patients. We further investigated the regulation of alternative splicing by RNA binding proteins (RBPs) with altered m6A modification and constructed a regulatory network among these RBPs, regulated alternative splicing events (RASEs) and regulated alternative splicing genes (RASGs) in CA. Results The results show that the m6A level in CA tissues differed from that in the paired controls. Furthermore, cell cycle- and cell adhesion- associated genes with m6A modification were differentially expressed in CA tissues compared to the paired controls. In particular, seven RNA binding protein genes with specific m6A methylated sites, showed a higher or lower expression at the mRNA level in CA tissues than in the paired normal tissues. In addition, these differentially expressed RNA binding protein genes would regulate the alternative splicing pattern of apoptotic process genes in CA tissue. Conclusions Our study reveals a sophisticated m6A modification profile in CA tissue that affects the response of host cells to HPV infection, and provides cues for the further exploration of the roles of m6A and the development of a novel treatment strategy for CA.

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“…Alarmingly, over 90% of these deaths occurred in low-and middle-income countries. CC is unique among malignancies for having a well-established cause, which has paved the way for early screening and treatment [3]. Conventional clinical screening methods include vaginal colposcopy, cytological examination (such as the Thinprep Cytologic Test, TCT), and Human Papillomavirus (HPV) testing [4].…”

Section: Introductionmentioning

confidence: 99%

Identification of Potential Diagnostic and Prognostic Biomarkers for Cervical Cancer

Zhao,

Xia,

Dong

2023

Preprint

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Objective To explore potential diagnostic and prognostic markers of cervical cancer by using GEO and TCGA databases.Methods Expression matrices related to cervical cancer were downloaded from the GEO database. Gene expression and clinical-pathological data from TCGA and GTEx were obtained from the UCSC Xena database. Differentially expressed genes (DEGs) between normal and tumor tissue samples were identified using the limma package in R. DEGs were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses using the ClusterProfiler package. The Cox proportional hazard regression model was used to screen significant genes. ROC curve and multivariate Cox regression analysis were used to evaluate the prognostic value of multiple clinical features.Results In this study, 42 total DEGs were found, including 33 up-regulated genes and 9 down-regulated genes. GO analysis revealed that DEGs were involved in biological processes such as chromosomal segregation, nuclear division, and organelle fission. KEGG pathway analysis implicated Toll-like receptor and mismatch repair signaling pathways. 6 significant genes were identified by COX (p < 0.05) and CA9, GINS2, and SPP1 combined biomarkers divided cervical cancer patients into a high-risk group and a low-risk group. Moreover, the low-risk survival rate was significantly higher than the high-risk survival rate. Finally, multivariate Cox regression analysis showed that the combined biomarkers of CA9, GINS2, and SPP1 are independent predictors of the prognosis of cervical cancer patients.Conclusion The GEO and TCGA databases screened out the combined biomarkers of CA9, GINS2, and SPP1, which are independent prognostic predictors of cervical cancer.

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Human papillomavirus vaccination and cervical cancer risk

Cited by 64 publications

References 67 publications

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

KIF23 promotes cervical cancer progression via inhibiting NLRP3‐mediated pyroptosis

Alteration of RNA m6A methylation mediates aberrant RNA binding protein expression and alternative splicing in condyloma acuminatum

Identification of Potential Diagnostic and Prognostic Biomarkers for Cervical Cancer

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