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Cited by 19 publications
(19 citation statements)
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“…The genital and mucosal types belong to the genus alpha-papillomavirus that also contains some cutaneous types, which cause genital warts (condyloma). The CSCC-associated HPVs are divided into low-and high-risk types which are mainly causing genital warts and associated with invasive cervical cancer types, respectively [ 2 , 3 ]. Of the high-risk HPV types, HPV 16 and 18 are responsible for around 90% of all cervical cancer cases.…”
Section: Cervical Cancer and Hpvmentioning
confidence: 99%
See 1 more Smart Citation
“…The genital and mucosal types belong to the genus alpha-papillomavirus that also contains some cutaneous types, which cause genital warts (condyloma). The CSCC-associated HPVs are divided into low-and high-risk types which are mainly causing genital warts and associated with invasive cervical cancer types, respectively [ 2 , 3 ]. Of the high-risk HPV types, HPV 16 and 18 are responsible for around 90% of all cervical cancer cases.…”
Section: Cervical Cancer and Hpvmentioning
confidence: 99%
“…Cervical cancer is the fourth most common cancer in women and accounts for ~5,70,000 new cases and ~3,11,000 deaths worldwide in the year 2018 [ 1 ]. Persistent infection with high-risk HPVs remains a major risk factor of cervical cancer [ 2 ]. Most HPV infections are cleared within months by the immune system but a few high-risk subtypes like HPV16 and HPV18 persist and express viral oncogenes E6 and E7 which lead to increased genomic instability, accumulation of somatic mutations, and integration of HPV into the host genome resulting in cervical cancer [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…In turn, HPV-6 has also been found to inhibit the endogenous expression of SAMHD1 (68). It would therefore be crucial to verify whether SAMHD1 may serve a role in other virus-related tumors, such as Epstein-Barr virus-associated gastric cancer (69) and in the development of cervical cancer due to HPV infection (70). SAMHD1 is involved in homologous recombination in response to DNA damage, which only occurs in the S phase (55,71).…”
Section: Future Directions and Conclusionmentioning
confidence: 99%
“…It remains unknown how particularly the host cell metabolism is controlled by HPV to meet the increased energy demands. It has previously been described that high-risk alphaHPV early proteins interact with mitochondria 19 . Most recently it has further been demonstrated, that the E6 protein of high-risk alphaHPVs induces the mitochondrial metabolism by increasing the protein levels of various mitochondrial complexes 20 .…”
Section: Discussionmentioning
confidence: 99%