Human Papillomavirus Oncogenesis

Co-fatores do HPV na oncogênese cervical

“…O presente artigo de revisão explora os possíveis co-fatores do HPV na gênese do carcinoma escamoso do colo uterino, levando em conta apenas os fatores cuja associação com o vírus ou câncer cervical tenha sido documentada experimentalmente, e não apenas clínica ou epidemiologicamente. Dentre os 2,6,16,34,36,40,42,47,52,55 , bem como pelo esforço recente de pesquisadores no desenvolvimento de vacinas contra este vírus, com a finalidade de prevenção deste tipo de câncer 26,30,45,52 . A partir daí, esta revisão passa a explorar os possíveis co-fatores do HPV no processo de carcinogênese, levando em conta apenas os fatores cuja a associação com o vírus ou câncer cervical tenha sido documentada experimentalmente, e não apenas clínica ou epidemiologicamente.…”

Role of the Epstein-Barr Virus ZEBRA Protein and HPV in the Carcinogenesis of Nasopharyngeal Carcinoma

“…Low-risk types are associated with benign lesions such as warts, while infections with high-risk types progress to malignant lesions (Munoz et al 2003). More than 100 different HPV genotypes have been described, but only 30 genotypes identified in the female genital tract are associated with epithelial neoplasms ranging from benign common warts to malignant carcinoma of the uterine cervix (McGlennen 2000). It is w i d e l y r e p o r t e d t h a t i n a d d i t i o n t o H P V 16 and 18, which are frequently found in association with cervical cancer (CC), HPVs 31,33,35,39,45,51,52,56,58,59,68,73 and 82, while other three as probable high-risk types (types 26, 53, and 66) are also considered as carcinogenic (Munoz et al 2003).…”

Human papillomavirus detection in Moroccan patients with bladder cancer

“…The papillomaviruses are small double-stranded DNA viruses which infect squamous epithelia and display a very high selectivity for the specific epithelium infected [8,9]. More than 200 different HPV genotypes have been described, but only 40 genotypes can infect the genital tract [10] and are associated with epithelial neoplasms ranging from benign common warts to malignant carcinoma of the uterine cervix [11]. According to their ability to transform epithelial cells, HPV genotypes are divided into low-risk and high-risk types.…”

“…According to their ability to transform epithelial cells, HPV genotypes are divided into low-risk and high-risk types. Low-risk types are associated with benign lesions such as warts, while infections with high-risk types progress to malignant lesions [9,11,12]. The oncogenicity of the HPV highrisk type is due to the activity of two oncoproteins, E6 and E7 [13].…”