Human papillomavirus in pterygium

Gallagher, Michael J.; Giannoudis, Athina; Herrington, C. Simon; Hiscott, Paul

doi:10.1136/bjo.85.7.782

Cited by 79 publications

(89 citation statements)

References 10 publications

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“…The most frequent diagnoses were cataract (37%), chalazia (12%), corneal tears (10%), and eye trauma (9%). Patients presenting with pterygium or pingueculum were not included because it was previously suspected that these diseases were associated with HPV infection (Gallagher et al, 2001). A total of 309 controls were included.…”

Section: Study Participantsmentioning

confidence: 99%

Human papillomavirus infection and squamous cell carcinoma of the conjunctiva

et al. 2009

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BACKGROUND: Squamous cell carcinoma of the conjunctiva (SCCC) is associated with HIV-related immunosuppression, but human papillomavirus virus (HPV) is also suspected to have a role. We carried out a case -control study to assess the role of cutaneous and mucosal HPV types in SCCC, conjunctival dysplasia, and their combination (SCCC/dysplasia) in Uganda. METHODS: We compared HPV prevalence in frozen biopsies from 94 SCCC cases (79 of whom were found to be HIV-positive), 39 dysplasia cases (34 HIV-positive), and 285 hospital controls (128 HIV-positive) having other eye conditions that required surgery. Highly sensitive PCR assays that detect 75 HPV types were used. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed, adjusting for, or stratifying by age, sex, and HIV status. RESULTS: Cutaneous HPV types were detected in 45% of SCCC cases, 41% of dysplasia cases and 11% of controls. Human papillomavirus virus 5 and 8 were the most common types in SCCC, and most often occurred in combination with other types. Associations were observed between SCCC/dysplasia and detection of both single (OR ¼ 2.3; 1.2 -4.4) and multiple (OR ¼ 18.3; 6.2 -54.4) cutaneous HPV types, and were chiefly based on findings in HIV-positive patients. Cutaneous HPV infections were rarely observed among HIV-negative patients and the association with SCCC/dysplasia was not significant (OR ¼ 2.4; 0.6 -9.6) among them. Squamous cell carcinoma of the conjunctiva/dysplasia risk and mucosal HPV types were not associated in either HIV-positive or HIV-negative patients. CONCLUSIONS: We detected cutaneous HPV types in nearly half of SCCC/dysplasia cases and often multiple types (HPV5 and 8 being most common). The role of HIV (confounder or strong enhancer of cutaneous HPV carcinogenicity) is still uncertain.

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Section: Study Participantsmentioning

confidence: 99%

Human papillomavirus infection and squamous cell carcinoma of the conjunctiva

et al. 2009

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“…Recently, Sjö et al 9 reported that PCR gave positive results for HPV in 86 (81%) of 106 papilloma specimens studied. In addition, HPV was detected in all five papilloma cases studied by Saegusa et al, 19 and in 9 of 10 papilloma cases (90%) studied by Gallagher et al 3 The presence of HPV in papilloma has also been confirmed by Southern blotting and in situ hybridization. 20 Based on these reports and our data, it is likely that HPV is closely involved in the pathogenesis of conjunctival papillomas.…”

Section: Discussionmentioning

confidence: 63%

“…8,9 Also, several studies have shown that HPV DNA can be detected in pterygium by PCR. 3,10,11 However, the proportion of cases that are positive for HPV DNA shows marked variation; HPV DNA has been detected in up to 50% cases of pterygium, whereas other studies have failed to detect any. 12 Therefore, the involvement of HPV in the pathogenesis of pterygium remains controversial.…”

Section: Introductionmentioning

confidence: 98%

“…Although the aetiology of pterygium and papilloma has not been established, human papillomavirus (HPV) is thought to be one of the causative factors. [2][3][4][5] HPV is a family of double-stranded circular DNA viruses, of which more than 80 types have been identified. 6 HPVs have oncogenic potential and contribute to the progression of neoplastic conditions.…”

Section: Introductionmentioning

confidence: 99%

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Detection of human papillomavirus in pterygium and conjunctival papilloma by hybrid capture II and PCR assays

Takamura

Kubo

Tsuzuki

et al. 2008

Eye

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Aim To elucidate the putative role of human papillomavirus (HPV) infection in pterygium and conjunctival papilloma. Methods Hybrid capture II (HC-II) and polymerase chain reaction (PCR) assays were performed to detect HPV in pterygium (42 samples obtained from 40 patients) and conjunctival papilloma (8 samples from 6 patients). The amount of HPV DNA was evaluated by measurement of relative light units (RLUs) on a luminometer. Results All papilloma samples were positive for HPV DNA by PCR and HC-II. The RLU values for specimens of recurrent and re-recurrent papilloma were markedly higher than those for specimens of primary lesions. HPV was detected by PCR in 2 of 42 (4.8%) b-globin-positive pterygium specimens, whereas HC-II showed that HPV was negative in all pterygium samples. Conclusions Our results support the hypothesis that HPV DNA is associated with the pathogenesis of conjunctival papilloma, but not pterygium. RLU measurement by HC-II may serve as a marker for evaluating the activity of HPV in conjunctival tumours.

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“…However, pterygia display some tumourlike properties in their clinical appearance of local invasion and epithelial cell metaplasia. 2 Furthermore, the presence of oncogenic viruses, such as the human papilloma virus and herpes simplex virus, 3,4 loss of heterozygosity, 5 and abnormal p53 expression in pterygium lesions, 6,7 all suggest the possible neoplastic nature of pterygium. A model of pterygium formation is then proposed, in which genetic predisposition, environmental factors, and viral infections may participate in the multistep process.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of hOGG1 and risk of pterygium in Chinese

Hc¹,

Cc²,

Wm³

et al. 2004

Eye

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Purpose Ultraviolet irradiation is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium. The highly mutagenic 8-hydroxy-2 0 -deoxyguanosine, a marker for the evaluation of photo-oxidative DNA damage, can be repaired by human 8-oxoguanine glycosylase I (hOGG1). A transition of C to G at nucleotide position 1245 in exon 7 of the hOGG1 gene is associated with the substitution of cysteine for serine at codon 326. In this study, we investigated the association of the hOGG1 Ser326Cys polymorphism with pterygium in a Chinese population. Methods In all, 70 patients and 86 controls were enrolled in this study. The Ser326Cys polymorphism was determined by the polymerase chain reaction-restriction fragment-length polymorphism analysis. The association between this genetic polymorphism and risk of pterygium was examined by w 2 -test and logistic regression. Results The allelic frequencies for the Ser and Cys variants of hOGG1 gene were not significantly different between the two groups. However, when compared with Ser/ Ser and Ser/Cys genotypes combined, we found that the homozygous Cys/Cys genotype was more prevalent in pterygium patients than controls (P ¼ 0.024) with the odds ratio being 2.2 (95% CI: 1.1-4.5). In the pterygium group, the mean age of patients with the Cys/Cys genotype was younger than those with the other two genotypes (P ¼ 0.025). Conclusions Our findings suggest that the 1245C-G transition in exon 7 of the hOGG1 gene, which results in Ser326Cys substitution of the enzyme, might play a role in the susceptibility of humans to pterygium.

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Human papillomavirus in pterygium

Cited by 79 publications

References 10 publications

Human papillomavirus infection and squamous cell carcinoma of the conjunctiva

Human papillomavirus infection and squamous cell carcinoma of the conjunctiva

Detection of human papillomavirus in pterygium and conjunctival papilloma by hybrid capture II and PCR assays

Genetic polymorphism of hOGG1 and risk of pterygium in Chinese

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