Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil

Petito, G. Timothy; Carneiro, Megmar Aparecida dos Santos; Santos, Sílvia Helena de Rabello; Silva, Antônio Márcio Teodoro Cordeiro; Alencar, Rita de Cássia Gonçalves; Gontijo, Antonio Paulo; Saddi, Vera Aparecida

doi:10.1016/j.bjorl.2016.01.004

Cited by 30 publications

(41 citation statements)

References 34 publications

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“…Our study suggests that the burden of HPV-related OPSCC may be increasing in the Brazilian population according to recent data [20][21][22]25 and the HPV-positive OPSCC prevalence. However, HPV status in patients with OPSCC was not associated with distinct epidemiological features, with the exception of tobacco and alcohol consumption, in the studied population.…”

Section: Resultssupporting

confidence: 70%

“…Despite the lower prevalence of HPV positivity in Brazil compared with American and European studies, we observed a slow growth in the incidence of HPV-related OPSCC over the last decade. [20][21][22]25 We also found a higher prevalence of tobacco (55.1%) and alcohol (40.9%) consumption among patients with HPV-related OPSCC compared with findings in recent American studies. 4,11 A significant difference was observed in the distribution of smokers, according to HPV status; 55.1% and 80.2% were HPV-positive and HPV-negative, respectively.…”

Section: Discussionsupporting

confidence: 70%

“…22 In 2014, Lopez et al 21 described the prevalence of HPVpositive OPSCC as 10.5% in a Brazilian population. Moreover, in 2016, Betiol et al 20 found that the prevalence of HPV-related OPSCC was 17.7% in a tertiary Cancer Center in São Paulo, whereas Petito et al 25 found that 25.6% of patients with OPSCC tested positive for HPV. Furthermore, a systematic review of HPV infection in the Brazilian population found a 27.4% HPV positivity rate among patients with oral cancer and OPSCC.…”

Section: Discussionmentioning

confidence: 99%

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Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

et al. 2019

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Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with better tumor-response rates and survival outcomes. However, in some geographic regions, the impact of HPV infection on prognosis remains unclear. The aim of this study was to describe the patterns of recurrence and survival among patients treated for OPSCC in a geographic region with a reported low prevalence of HPV-related OPSCC. Methods: We retrospectively evaluated 215 patients diagnosed with American Joint Committee on Cancer (AJCC) stages I to IV OPSCC who were treated with upfront surgery or radiation therapy with or without chemotherapy in a tertiary Cancer Center in Brazil. The collected data included demographic information, HPV status, tobacco and alcohol consumption, and pathologic and treatment variables. The patterns of recurrence were recorded according to HPV status. Disease-specific survival and recurrencefree survival were calculated. Results: One hundred twenty-seven (59.1%) patients were diagnosed with HPVpositive OPSCC. According to the AJCC eighth edition, 34 (15.8%), 71 (33%), 47 (21.9%), and 60 (27.9%) patients had stage I, II, III, and IV disease, respectively. Surgery was performed in 109 (50.7%) cases, and upfront chemoradiation regimens were provided in 104 (48.4%, P = .69) patients. Overall, the 5-year cancer-specific survival was 73.5% and 68.1% for patients positive and negative to HPV, respectively. Tobacco status was considered the only independent prognostic factor for survival. Furthermore, HPV status was not associated with differences in recurrence rates (P = .68). While all distant relapses were found to be lung metastases in the HPV-negative group, we observed unusual sites of distant metastases in the HPV-positive group. Conclusions: HPV status was not associated with higher rates of survival among the investigated population. Moreover, smoking status was considered the only independent prognostic factor for survival. Furthermore, patients with HPVpositive tumors were more likely than patients with HPV-negative OPSCC to have unusual distant metastases.

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Section: Resultssupporting

confidence: 70%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

et al. 2019

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“…Although the patients with HPV lesions are generally described as younger, nonsmokers and non-alcoholic, these data are still controversial. Our data, similar to the data of several authors, show no association between these factors and HPV status 20 , 24 . No significant difference was observed in the frequency of HPV infection between men and women, as also observed in the study by Tatar, et al 26 (2015).…”

Section: Discussionsupporting

confidence: 92%

High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

et al. 2017

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The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil.Material and Methods We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR.Results Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11).Conclusion Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions.

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“…W 2014 roku przeprowadzono badanie, w którym analizowano 82 chorych z płaskonabłonkowymi rakami jamy ustnej oraz gardła. HPV został wykryty w 21 przypadkach, z czego HPV 16 stanowiło 1/3 a HPV 18-14,3% [41].…”

Section: Chorobotwórczośćunclassified

Papillomaviruses: HPV as the etiological factor of head and neck cancers

Wiciński

Malinowski

Węclewicz

et al. 2018

Postępy Mikrobiologii - Advancements of Microbiology

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Streszczenie: Wirus HPV, należący do Papillomaviridae, powoduje raka jąder, płuc, głowy oraz szyi. Obecnie szacuje się, że istnieje około 190 rodzajów HPV. Ponad 700 milionów osób na całym świecie jest zarażonych tym wirusem. W Stanach Zjednoczonych co roku występuje 14 milionów nowych zakażeń. Najczęściej zmiany nowotworowe głowy i szyi powodują wirusy HPV typu 16 i 18. Pacjent zakaża się wirusem poprzez kontakt nabłonka z wirusem lub inną zainfekowaną tkanką nabłonkową, na przykład w efekcie stosunku płciowego. Możliwe jest również przekazywanie patogenu od matki podczas porodu. Choroby związane z HPV to np. rak krtani, leukoplakia, rak migdałków lub choroba Bowena. Dostępne są szczepionki np. 9-walentna szczepionka przeciwko HPV o nazwie Gardasil-9.

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Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil

Abstract: The results obtained in the present study, with respect to the presence of the high-risk HPV16 and HPV18 genotypes, highlight the importance of human papilomavirus vaccination in the control of oral cavity and oropharynx carcinomas.

Cited by 30 publications

References 34 publications

Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

Papillomaviruses: HPV as the etiological factor of head and neck cancers

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