Human Papillomavirus in Larynx

Aaltonen, Leena‐Maija; Rihkanen, Heikki; Vaheri, Antti

doi:10.1097/00005537-200204000-00020

Cited by 83 publications

(78 citation statements)

References 90 publications

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“…Studies dedicated to HPV infections in LSCCs have reported wide variations in frequency that range from 3 to 85% (2,(4)(5)(6)(7)(8)(9)(10). LSCCs are infected with a spectrum of oncogenic and non-oncogenic HPV types.…”

Section: Discussionmentioning

confidence: 99%

“…Besides being associated with well-established risk factors, such as smoking and alcohol use, the development of laryngeal carcinoma (LSCC) has also been reported to be associated with some human papillomaviruses (HPVs) (2). Nearly 30 years ago, Gissman and colleagues detected the DNA sequences of HPV-6 and -11 in genital and laryngeal papillomas (3).…”

Section: Introductionmentioning

confidence: 99%

“…Nearly 30 years ago, Gissman and colleagues detected the DNA sequences of HPV-6 and -11 in genital and laryngeal papillomas (3). Laryngeal papillomatosis is the most prevalent benign tumor of the larynx in children, and mother-to-child transmission is probably involved in juvenile-onset papillomatosis (2). Several of the 120 HPV genotypes have been detected in LSCCs, and the prevalence of HPV has been estimated to range between 3-85% (2,(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Laryngeal papillomatosis is the most prevalent benign tumor of the larynx in children, and mother-to-child transmission is probably involved in juvenile-onset papillomatosis (2). Several of the 120 HPV genotypes have been detected in LSCCs, and the prevalence of HPV has been estimated to range between 3-85% (2,(4)(5)(6)(7)(8)(9)(10). Although the most important clinical manifestation of laryngeal HPV infection is laryngeal papillomatosis (HPV incidence: 83-100%), HPV DNA is also detected in normal mucosa (incidence: 20%) and in LSCCs (2).…”

Section: Introductionmentioning

confidence: 99%

“…Several of the 120 HPV genotypes have been detected in LSCCs, and the prevalence of HPV has been estimated to range between 3-85% (2,(4)(5)(6)(7)(8)(9)(10). Although the most important clinical manifestation of laryngeal HPV infection is laryngeal papillomatosis (HPV incidence: 83-100%), HPV DNA is also detected in normal mucosa (incidence: 20%) and in LSCCs (2). Indeed, Nunez et al (11) showed that post-mortem specimens of macroscopically normal laryngeal mucosa and hypopharyngeal mucosa were HPV + in 25 and 18% of cases, respectively.…”

Section: Introductionmentioning

confidence: 99%

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High incidence of high-risk HPV in benign and malignant lesions of the larynx

Duray

Descamps²,

Arafa³

et al. 2011

Int J Oncol

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Abstract. The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffinembedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presence of HPV DNA by GP5 + /GP6 + consensus PCR and E6/E7 type-specific PCR for HPV types 6,11,16,18,31,33,35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. In LSCCs, immunohistochemical staining of p16, p53 and EGFR was also assessed. The E6/E7 type-specific PCR showed that 44 out of 59 LSCC patients (i.e., 75%) had high-risk (hr) HPV types and that 27 out of 35 LBL patients (i.e., 77%) had hrHPV types. HPV-16 viral load was significantly higher in LSCC than in LBL patients (p<10 -6 ). The presence of hrHPV DNA did not correlate with the proportion of disease-free patients. Comparable levels of p16, p53 and EGFR expression were observed in the hrHPV + tumor group (100% p16 + , 56% p53 + and 97% EGFR + ) and in the HPV -or low-risk (lr) HPV + tumor group (92% p16 + , 66% p53 + and 100% EGFR + ). A very high prevalence of oncogenic HPV-16 was found in a series of benign and malignant laryngeal lesions. LSCC appears to be characterized by an active hrHPV infection. In LSCCs, the hrHPV + subgroup had a similar prognosis (in terms of risk of recurrence) as the HPV -subgroup.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High incidence of high-risk HPV in benign and malignant lesions of the larynx

Duray

Descamps²,

Arafa³

et al. 2011

Int J Oncol

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National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis

Reeves

Ruparelia²,

Swanson³

et al. 2003

Arch Otolaryngol Head Neck Surg

188

131

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The registry has established the clinical course of JORRP in a large sample representative of the United States. Young age was the most important determinant of disease severity (frequency of surgery, extent of disease at diagnosis, and progression of disease). Addressing questions of pathogenesis and disease course will require a revised data collection instrument and molecular analysis of tissues.

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