1987
DOI: 10.1001/archderm.123.3.354
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Human papillomavirus heterogeneity in 36 renal transplant recipients

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1987
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Cited by 60 publications
(17 citation statements)
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“…The detection of mucosal HPV types 6, 11, 16 and 18 which was previously described in few cases of skin lesions from the general population [2,15,28], was a common feature in our grafted patients [37]. HPV type 5, commonly found in skin cancers from patients with epidermodysplasia verruciformis [43], has also been previously found in grafted patient skin lesions [3,36,42]. These virological data, together with clinical and histological observations [13], are in favor of a role of HPV in the malignant progression of cutaneous lesions from grafted patients.…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…The detection of mucosal HPV types 6, 11, 16 and 18 which was previously described in few cases of skin lesions from the general population [2,15,28], was a common feature in our grafted patients [37]. HPV type 5, commonly found in skin cancers from patients with epidermodysplasia verruciformis [43], has also been previously found in grafted patient skin lesions [3,36,42]. These virological data, together with clinical and histological observations [13], are in favor of a role of HPV in the malignant progression of cutaneous lesions from grafted patients.…”
Section: Discussionsupporting
confidence: 75%
“…As potentially oncogenic HPV types 16 and 18 E6 proteins are known to bind p53 protein in vitro [30], and HPV infection is common in cutaneous lesions from grafted patients [3,42], it was interesting to investigate the presence of HPV DNA in such lesions. In benign lesions from non-immunocompromised control patients, only low risk HPV types 1 or 2 and 6 of 11 were respectively detected in warts and anogenital condylomas as usually described [43].…”
Section: Discussionmentioning
confidence: 99%
“…HPV 5,8,9,12,14,15,17,[19][20][21][22][23][24][25][36][37][38]47,49). [34][35][36] However, a susceptibility locus to EV mapped to chromosome 17qter region, 37 frequent coinfection with HPV 3, 38 and the rarity of EV-like eruptions in immunodeficient states [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] indicate that other, nonimmunological factors operate in the development of clinically diagnosable EV infection. None the less, defects of cellmediated immunity such as CD4 lymphopenia in this case, or cutaneous anergy, decreased response to T-cell mitogens (e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Although in most cases clinical and histological features of the warts [17,42,43,46,47,48] and the associated HPV types [17,46,48] in immunosuppressed patients do not differ from those in the general population, rare cases of acquired EV-like eruption have been reported in immunosuppressed patients, including patients with organ transplants [15,16,17,18,19], lepromatous leprosy [49], Hodgkin lymphoma [20], systemic lupus erythematosus [21,22], human immunodeficiency virus infection [19,23,24,25,26,27,28,29,30,31,32,33,34,50,51], severe combined immune deficiency caused by γc or JAK3 deficiency after hemopoietic stem cell transplantation [35], and in the setting of graft-versus-host disease [36]. Treatment with biological agents may also increase the risk for HPV infections including acquired EV [52].…”
Section: Discussionmentioning
confidence: 99%
“…The correlation between the HPV type and clinical and histological features exists also in immunosuppressed patients [17,35,46,48]. In fact, β-papillomaviruses were detected in all reported cases of acquired EV-like eruption in which the causative HPV type was determined [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]. Therefore, this is the first documentation of an association between EV-like eruption and γ-papillomavirus infection.…”
Section: Discussionmentioning
confidence: 99%