Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection

Nicolau, Sérgio Mancini; Camargo, Clóvis G.C.; Stávale, João Norberto; Castelo, Adauto; Dores, Gerson Botacini das; Lörincz, Attila T.; Lima, Geraldo Rodrigues de

doi:10.1016/j.urology.2004.09.031

Cited by 94 publications

(112 citation statements)

References 18 publications

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“…In a study on 50 partners of HPV-positive women in Italy, Giovannelli et al found that parallel testing by penile brushing and urethral brushing yielded 100% rates of HPV detection (13). That finding is consistent with the study from Nicolau et al who also used hc2 HPV DNA test and found that the HPV detection rate increased from 58% to 70% when urethral sampling was analysed concomitantly with the penile brushings (11). In our population HPV prevalence would be 30.01% if only external genital samples were used, compared to 36.66% prevalence rate when both sites were analysed.…”

Section: Fig 1 Graph Showing Prevalence Rates For Hpv-positive Indimentioning

confidence: 52%

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Prevalence of HPV Infection in Croatian Men during a 12-year Period: a Comparative Study of External Genital and Urethral Swabs

Profozić¹,

Meštrović²,

Savić³

et al. 2016

Cent Eur J Public Health

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SUMMARYAim: The aim of the study was to compare the prevalence and distribution of both low-risk and high-risk HPV infection of the urethra and outer genital region in Croatian men. Thus far there is a consensus that sampling the coronal sulcus and glans of the penis is essential for adequately assessing HPV status in men but less agreement is noted for urethral sampling.Methods: External genital brushing and urethral swabs were taken from 1,342 men during a 12-year period and tested with the hc2 HPV DNA Test using Hybrid Capture 2 technology.Results: The overall prevalence of male HPV infection in this study was 36.66%. Infection with high-risk HPV types (44.72%) was significantly more frequent than infection with low-risk HPV types (28.86%) or co-infection with both low-risk and high-risk HPV types (26.42%). HPV was more frequently demonstrated in the outer genital area (58.33%) when compared to the sole infection of the urethra (17.89%) or infection of both genital sites (23.78%).Conclusions: Results from this study indicate high prevalence of HPV infection in men and suggest that optimal sampling method for the testing of men is the combination of external genital and urethral swabs. Further research about the proper collection of biological samples and testing methods for HPV detection in men is necessary since our future end-goal is to implement standardized guidelines on sampling and diagnostic testing of males.

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Section: Fig 1 Graph Showing Prevalence Rates For Hpv-positive Indimentioning

confidence: 52%

“…Hence in the absence of clinical lesions, the most trustworthy diagnostic approach for men is testing for HPV DNA (4,11). The overall prevalence of HPV in men is quite variable depending on the study and it ranges from 1.3% to 72.9% (12).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of HPV Infection in Croatian Men during a 12-year Period: a Comparative Study of External Genital and Urethral Swabs

Profozić¹,

Meštrović²,

Savić³

et al. 2016

Cent Eur J Public Health

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“…Additionally, the Hybrid Capture II test can be automated; the results are not subject to human judgement; they have been successfully implemented in several Latin American laboratories and have shown excellent inter-laboratory agreement. 14,[27][28][29][30][31][32][33][34][35][36] There was only one insufficient sample for testing, a remarkable achievement compared to inadequate rates for cytology (5% for LBC and 11% for CC).…”

Section: Hpv Testingmentioning

confidence: 99%

Cervical screening by visual inspection, HPV testing, liquid‐based and conventional cytology in Amazonian Peru

Almonte

Ferreccio

Winkler

et al. 2007

Intl Journal of Cancer

108

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Cervical cancer is an important public health problem in many developing countries, where cytology screening has been ineffective. We compared four tests to identify the most appropriate for screening in countries with limited resources. Nineteen midwives screened 5,435 women with visual inspection (VIA) and collected cervical samples for HPV testing, liquid-based cytology (LBC) and conventional cytology (CC). If VIA was positive, a doctor performed magnified VIA. CC was read locally, LBC was read in Lima and HPV testing was done in London. Women with a positive screening test were offered colposcopy or cryotherapy (with biopsy). Inadequacy rates were 5% and 11% for LBC and CC respectively, and less than 0.1% for VIA and HPV. One thousand eight hundred eightyone women (84% of 2,236) accepted colposcopy/cryotherapy: 79 had carcinoma in situ or cancer (CIS1), 27 had severe-and 42 moderate-dysplasia on histology. We estimated a further 6.5 cases of CIS1 in women without a biopsy. Sensitivity for CIS1 (specificity for less than moderate dysplasia) was 41.2% (76.7%) for VIA, 95.8% (89.3%) for HPV, 80.3% (83.7%) for LBC, and 42.5% (98.7%) for CC. Sensitivities for moderate dysplasia or worse were better for VIA (54.9%) and less favourable for HPV and cytology. In this setting, VIA and CC missed the majority of high-grade disease. Overall, HPV testing performed best. VIA gives immediate results, but will require investment in regular training and supervision. Further work is needed to determine whether screened-positive women should all be treated or triaged with a more specific test. ' 2007 Wiley-Liss, Inc.Key words: Pap smear; hybrid capture; low-resource settings; clinical trial; screening Cervical cancer is the commonest female cancer, a major cause of death and an important public health problem in many developing countries. 1 Screening by routine cytology, using Papanicolaou stain (Pap), has had a major impact on cervical cancer rates in many developed countries, but not in any developing country despite its widespread use. 2-4 A number of other cervical screening tests have been proposed. Here, we wanted to identify the most appropriate test for use in developing countries with high rates of cervical cancer and limited resources.In Peru, as in most Latin American countries, cervical cancer is usually detected in an advanced incurable stage, despite widespread use of cytology screening. 5,6 Others have documented numerous problems of screening in Peru. Samples may be poorly collected, slides may be incorrectly labelled and some never reach the laboratory. Cytology results are sometimes wrongly transcribed or are not reported. 6 Cytology laboratories suffer from deficient infrastructure, inadequate training and supervision, staff shortages, lack of followup procedures and lack of internal and external quality control leading to suboptimal reading of cytology for which considerable expertise is required. This study was set up to investigate a variety of screening tests that may be more effective in such a setting.L...

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“…In literature, these data vary widely and few studies have been published. The prevalence of HPV in anal site in heterosexual populations is very heterogeneous in these papers, ranging from 1.2, 8, and 24.8% (19)(20)(21) . We emphasize that the prevalence we found is high, especially for HPV types 6 and 11 ( Table 2), but we studied subjects with genital lesions clinically detected, thus increasing the risk of infection in other sites and confirming the presence of HPV in the host probably due to self-inoculation.…”

Section: Discussionmentioning

confidence: 95%

Human papillomavirus infection in multiple sites

Cordeiro¹,

Carestiato²,

Gouvêa³

et al. 2014

J bras doenças sex transm

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Introduction: Studies concerning human papillomavirus natural history have been focused on cervical infection and disease, but have scarcely described anal infections, especially in clinically health population. Hence, knowledge on HPV natural history is recently being investigated although viral maintenance in hosts is poorly understood. Detection on diverse, extragenital sites may add in the elucidation of infection-dissemination-reinfection cycle reported on the human genital tract. Besides that, it is evident the importance of an adequate screening of the viruses for appropriate diagnosis, mainly in the first steps of the neoplasia in order to provide a better prognosis. Our results pointed out HPV prevalence rates in genital lesions of 87% (80/92) and of 47.8% (44/92) for anal samples. We pointed out that this high prevalence is due to clinically detected lesions, that contributes to the risk of extragenital infections, mainly by host auto-inoculation. Despite the difference in samples size, we did not find statistical relevant differences related with genera (men 85.1% and women 92%; p>0.05), corroborating the idea of no tropism differences by sex. Nevertheless, for anal samples, statistically significant differences were found between men and women (68% of anal HPV infection in women against 40.3% in men (p=0.038). These results reveal that female anal infections are more frequent than in men, suggesting that infection by autoinoculation occurs and can render this site as an HPV reservoir, occasionally becoming clinical lesions. Hormonal profile, sexual behavior and differences among body sites can explain these differences here described. Our study is a preliminary evaluation of HPV infection in human multiple sites. Keywords: papillomavirus infections; polymerase chain reaction; anus. RESUMO Introdução:Muitos estudos sobre a história natural do papilomavírus humano (HPV) têm focado nas infecções cervicais, mas pouco tem se falado sobre infecções anais em pacientes assintomáticos. Assim, a história natural do HPV ainda está em construção e os mecanismos de manutenção dele no organismo hospedeiro são pouco compreendidos. Entendemos que a detecção do vírus em sítios extragenitais poderá ajudar na compreensão da cadeia de infecção-disseminação-reinfecção pelo HPV no trato genital humano. Além disso, é evidente a importância de um rastreio adequado do vírus diante de diagnósticos clínicos, principalmente no período inicial da lesão, provendo, assim, um melhor prognóstico. Nossos resultados apontaram uma prevalência da infecção por HPV em lesões genitais de 87% (80/92) e nas amostras anais tal prevalência foi de 47,8% (44/92). Ressaltamos que nossa prevalência foi alta, mas estudamos indivíduos com lesões genitais clinicamente detectadas, aumentando, assim, o risco de infecção em outros sítios e confirmando a ocorrência da presença do HPV no hospedeiro, provavelmente decorrente de autoinoculação. Apesar da diferença entre o número de indivíduos dos sexos feminino e masculino em nosso estudo, não enco...

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Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection

Cited by 94 publications

References 18 publications

Prevalence of HPV Infection in Croatian Men during a 12-year Period: a Comparative Study of External Genital and Urethral Swabs

Prevalence of HPV Infection in Croatian Men during a 12-year Period: a Comparative Study of External Genital and Urethral Swabs

Cervical screening by visual inspection, HPV testing, liquid‐based and conventional cytology in Amazonian Peru

Human papillomavirus infection in multiple sites

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