Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Abstract

Certain types of human papillomaviruses (HPVs) are undoubtedly involved in genesis of human malignancies. HPV plays an etiological role in cervical cancer, but also in many vaginal, vulvar, anal and penile cancers, as well as head and neck cancers. In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV. Moreover, HPV forms have detected in several other cancers including esophageal squamous cell carcinoma, lung, prostate, ovarian, breast, skin, colorectal and urinary tract cancers, but associations with etiology in these cases is controversial. The aim of this systematic assessment was to estimate the prevalence of HPV infection and HPV types in HPV-associated cancers, HPV-related non-malignant diseases and in cancers that may be associated with HPV in Iran. The present investiagtion covered 61 studies on a variety of cancers in Iranian populations. HPV prevalence was 77.5 % and 32.4% in cervical cancer and head and neck cancers, respectively. HPV was detected in 23.1%, 22.2%, 10.4%, 30.9%, 14% and 25.2% of esophageal squamous cell, lung, prostate, urinary tract cancers, breast and skin cancers, respectively. HPV16 and 18 were the most frequent HPV types in all cancers. The findings of present study imply that current HPV vaccines for cervical cancer may decrease the burden of other cancers if they are really related to HPV.

No Association Between Human Papillomavirus and Prostate Cancer

“…HPV vaccine is developed for the prevention of cervical cancer in some countries. If HPV infection is associated with the risk of prostate cancer, it all cancers (6). In the present study, the majority of histological type of prostate cancer was adenocarcinoma.…”

Distribution of Human Papillomavirus Genotypes among Women in Mashhad, Iran

“…In line with our study, the most frequently found HPVs in cervical carcinoma cases were HPV16 (accounting for over 50%) and HPV18 (12%) in numerous reports [24] . Mahmoudi et al [25] studied the role of HPV genotypes in cervical cancer in Yazd, Iran, and observed a high frequency of HPV16 (70%) and HPV18 (16.7%), followed by types 33, 45, and 73, respectively 41 [26] . These findings are consistent with our study.…”

“…The average global prevalence of HPV infection has been reported to be almost 10% (in the range of 1.4-25.6%). This group of viruses consists of low-risk HPVs that do not cause cancer but can cause skin warts (genotypes 6, 11, 42, and 44), and high-risk HPVs that cause cancer (genotypes 16,18,26,31,33,35,39,45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82). Neoplastic and cervical cancer may occur due to exposure to high-risk HPV infection.…”

Prevalence of High risk Human Papillomavirus in cervical dysplasia and cancer samples from twin cities in Pakistan

“…Major high risk HPV subtypes reported in neighbouring countries such as Saudi Arabia include: HPV 11,33,31,39, 45, 51, 52, 53, 58, 59, 66, 68 and 73 28. HPV subtypes reported in Iran include;HPV 6, 11,31,33,35,39,42, 43, 44, 45,51, 52, 56, 58, 59, 66 and 68.…”