Human papillomavirus and lung cancer: an overview and a meta-analysis

Цыганов, М. М.; Певзнер, А. М.; Ибрагимова, М. К.; Deryusheva, Irina V; Litviakov, N. V.

doi:10.1007/s00432-019-02960-w

Cited by 21 publications

(44 citation statements)

References 109 publications

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“…As PV DNA has been detected in many studies of human lung, breast, and bladder cancers, the failure to detect either CPV or FcaPV DNA in any of the 70 samples in the present study was perhaps surprising. However, large variations in the rate of detection of PV DNA have been reported in studies of human cancers, with a proportion of studies of lung, breast, and bladder cancers not detecting PV DNA within the cancers [13,14]. It is possible that the preponderance of studies that report high rates of PV DNA within these neoplasms is due to publication bias, whereby studies in which HPV DNA was detected are easier to publish than studies that confirm previous negative results.…”

Section: Discussionmentioning

confidence: 99%

“…Geographical differences in the rate of detection of HPVs within lung, breast, and bladder neoplasms have been reported. For example, while lung cancers in Canada, Singapore, and the Netherlands did not contain HPV DNA, in Brazil, Korea, Greece, and Taiwan [14], HPV DNA was detected in over 40% of lung cancers. In the present study, only samples from dogs and cats from New Zealand were evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…A potential role of PVs in the development of human epithelial lung cancer was first suggested in 1979 [13]. Since then, studies have reported detection rates of PV DNA in lung cancers that have varied from 0% to 80% [14]. The majority of studies report the detection of ‘high-risk’ human papillomavirus (HPV) DNA in around a third of samples, although HPV DNA was also detected in non-neoplastic tissue in many of these studies [14].…”

Section: Introductionmentioning

confidence: 99%

“…Since then, studies have reported detection rates of PV DNA in lung cancers that have varied from 0% to 80% [14]. The majority of studies report the detection of ‘high-risk’ human papillomavirus (HPV) DNA in around a third of samples, although HPV DNA was also detected in non-neoplastic tissue in many of these studies [14]. Therefore, while there is evidence to suggest a potential role of PVs in human lung cancer, the role of these viruses is unresolved.…”

Section: Introductionmentioning

confidence: 99%

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Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Munday

MacLachlan²,

Perrott

et al. 2019

Animals

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Simple SummaryPapillomaviruses (PVs) are well established to cause genital and oral cancer in humans. Additionally, some evidence suggests that these viruses may also have a role in the development of human lung, breast, and bladder cancer. Recent studies have revealed that PVs can influence the development of some cancers in cats and, less frequently, in dogs. In the present study, 47 lung, mammary gland, and bladder cancers in dogs and 25 cancers in cats were evaluated for evidence of any role PVs may have in cancer development. Histology did not reveal any lesions suggestive of PV infection, and no PV DNA was amplified from any cancer. Therefore, these findings suggest that PVs do not frequently infect these tissues and are therefore unlikely to be significant factors in the development of lung, mammary gland, or bladder cancer in either dogs or cats.AbstractPapillomaviruses (PVs) cause around 5% of all human cancers, including most cervical cancers and around a quarter of all oral cancers. Additionally, some studies have suggested that PVs could cause a proportion of human lung, breast, and bladder cancers. As PVs have been associated with skin cancer in cats and, more rarely, dogs, it was hypothesized that these viruses could also contribute to epithelial cancers of the lung, mammary gland, and bladder of dogs and cats. Formalin-fixed paraffin-embedded samples of 47 canine and 25 feline cancers were examined histologically for evidence of PV infection. Additionally, three sets of consensus PCR primers were used to amplify PV DNA from the samples. No histological evidence of PV infection was visible in any of the cancers. DNA from a bovine PV type was amplified from one sample, while two different samples were found to contain human PV DNA. However, these were considered to be contaminants, and no canine or feline PV types were amplified from any of the cancers. These results suggest that PVs do not frequently infect the lung, mammary gland, or bladder of dogs and cats and therefore are unlikely to be significant factors in the development of cancers in these tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Munday

MacLachlan²,

Perrott

et al. 2019

Animals

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“…More recent meta--analyses [9] show that HPV infection, especially HPV 16 and 18 infections, signifi cantly increases lung cancer risk. At the same time, the overview [10] concluded, that the published data do not provide evidence of the involvement of HPV in the pathogenesis of lung cancer. A recent ecological study in Russia and the USA with the inclusion of possible HPV association with lung cancer have provided results coherent with linear no-threshold dependency between lung cancer mortality and radon concentration in dwellings [11].…”

Section: Introductionmentioning

confidence: 99%

Combined analysis of onco-epidemiological studies of the relationship between lung cancer and indoor radon exposure

Yarmoshenko

Malinovsky

2020

Nukleonika

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AbstractObjectives: Recent results of epidemiological and medical statistics studies of lung cancer and indoor radon in different regions of the world make a relevant new combined analysis of residential exposure health effects. In particular, new data were obtained by means of a meta-analysis of case-control studies as well as taking into account a confounding effect of human papillomavirus infection in studies of geographically aggregated data.Materials and methods: Two sources of epidemiological data are considered: (1) studies of ecological design and (2) case-control studies. Ecological studies included the analysis performed for the USA counties and Russian oblasts with adjusting for the main confounders. Data on the case-control studies were gained from the meta-analysis of 31 individual studies with a weighting of obtained odds ratios according to the quality of radon exposure reconstruction and size of the reference group. Estimations of lung cancer excess relative risk (ERR) associated with indoor radon exposure are combined.Results: Two types of epidemiological study design provided generally consistent EER estimations. The combined value of ERR due to radon exposure is 0.14 (90% CI: 0.10–0.18) per 100 Bq/m3.Conclusion: Available geographically aggregated data in regions of Russia and the United States and the meta-analysis of case-control studies conducted in a large number of countries confirm the association of lung cancer with indoor radon exposure.

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Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?

Schulte

Steinmetz

Furtado

et al. 2020

Head and Neck Pathol

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Human papillomavirus and lung cancer: an overview and a meta-analysis

Cited by 21 publications

References 109 publications

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Combined analysis of onco-epidemiological studies of the relationship between lung cancer and indoor radon exposure

Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?

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