Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature

Lorenzon, Laura; Ferri, Mario; Pilozzi, Emanuela; Torrisi, Maria Rosaria; Ziparo, Vincenzo; French, Deborah

doi:10.1007/s00384-010-1049-8

Cited by 44 publications

(57 citation statements)

References 22 publications

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“…Although several investigators have found an association between HPV and colorectal carcinoma, [54][55][56] the role of HPV in carcinogenesis of the colon remains to be elucidated. 57 Morphologically, low-grade and high-grade HPVrelated squamous mucosal lesions are similar whether they occur in the anus or cervix. Their morphologic similarities far outweigh their differences, both cytologically and histologically, as seen in Figures 5 and 6.…”

Section: Histology Of Ain and Anal Cancermentioning

confidence: 99%

Anal cancer and cervical cancer screening: Key differences

Darragh

Winkler

2010

Cancer Cytopathology

192

203

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Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to increase in high-risk populations, particularly men who have sex with men regardless of their human immunodeficiency virus (HIV) status. There are no national screening guidelines for anal cancer. Using the success of cervical cancer screening as a model, anal cancer screening approaches apply anal cytology, highresolution anoscopy, and directed biopsy to guide treatment and management strategies. Although much has been learned about the natural history and epidemiology of anal intraepithelial neoplasia (AIN), the rate of progression of high-grade anal intraepithelial neoplasia (HGAIN) to invasive squamous cell carcinomas is not known. The impact of screening and treatment of HGAIN on morbidity and mortality from anal cancer are also unknown. Because the incidence of HGAIN and anal squamous cell carcinoma continue to increase, it is imperative to find pathways for effective screening, early detection, and therapeutic intervention. This article provides an overview of anal cancer screening while highlighting its differences from cervi- Compared with cervical cancer, anal cancer is rare. The National Cancer Institute estimates that 5260 patients will be diagnosed with anal cancer in 2010 and that 720 men and women will die of the disease. 1 Compare this to cervical cancer statistics in the United States for 2010: 12,200 will be diagnosed with cervical cancer and 4210 women will die and this is with successful opportunistic Papanicolaou (Pap) testing to screen for this cancer in the United States. Yet, in patients with the highest risk of anal cancer, its incidence was more than double that of cervical cancer prior to the initiation of Pap screening and is increasing, while rates for cervical cancer continue to decrease. As the incidence of anal carcinoma increases in populations at risk, cytologic screening, combined with early detection and treatment, has been proposed as a method to reduce the morbidity and mortality from invasive anal squamous cell carcinoma (ASCC).

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Section: Histology Of Ain and Anal Cancermentioning

confidence: 99%

Anal cancer and cervical cancer screening: Key differences

Darragh

Winkler

2010

Cancer Cytopathology

192

203

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“…Therefore, several recent studies including one from our group pointed-out that high-risk HPVs are present in human CRCs, specifically types 16, 18, 31, 33, and 35 [7,12,15,16,52]. Moreover, six recent meta-analysis studies confirmed the presence of high-risk HPVs in human CRCs [70,[91][92][93][94][95]; however, the prevalence of high-risk HPVs varied from one geographic location to another [7,52]. Meanwhile, it was stated that high-risk HPVs are present especially in the invasive form of these malignancies worldwide [15].…”

Section: High-risk Hpvs In Colorectal Cancersmentioning

confidence: 96%

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

Moustafa¹,

Al-Antary²,

Yasmeen³

2016

Human Papillomavirus - Research in a Global Perspective

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Colorectal, colon and rectal, cancer is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process implicating environmental and lifestyle factors in addition to gene mutation and viral infections. On the other hand, it is well established that human papillomaviruses (HPVs) infection play a crucial role in certain types of human carcinomas including cervical and head and neck (HN); as roughly 96% and 30% of these cancers are positive for high-risk HPVs, respectively. Moreover, it has been reported that the presence of high-risk HPVs is associated with vascular invasion, lymph node metastases, and tumor size in cervical and HN cancers. Recently, several investigations pointed-out that high-risk HPVs are present in around 70% of human colorectal cancers. Likewise, our group has demonstrated that E6/E7 oncoproteins of HPV type 16 convert noninvasive and nonmetastatic human cancer cells to invasive and metastatic form. Accordingly, it is evident that high-risk HPVs are present in human colorectal cancers where they could play an important role in the development of these malignancies. In this chapter, we will discuss the presence and role of high-risk HPVs in human colorectal carcinogenesis and metastasis; particularly, the interaction between E5 and E6/E7 oncoproteins of high-risk HPVs in colorectal malignancies, which has been linked with the initiation and progression of these tumors.

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“…Nos últimos anos, entretanto, artigos da literatura especializada vêm mostrando a presença do DNA do HPV em amostras de tecido de carcinomas do esôfa-go 13 , estômago 14,15 , pulmão 14 , mama 16 e colorretal [17][18][19] . O HPV foi detectado em até 37,5% dos adenocarcinomas gástricos 15 , e em 27,8% dos CEC esofágicos 20 , havendo diferença em áreas de alta e de baixa prevalência para esse tumor maligno (65 e 6%, respectivamente) 21 .…”

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“…O HPV foi detectado em 51,4% dos CEC e em 16,2% dos adenocarcinomas do pulmão, sendo que o risco de CEC pulmonar é 3,5 vezes maior em doentes contaminados pelo HPV 23 , embora, outros neguem essa associação 24 . O HPV foi encontrado entre 41,7 e 82,1% dos adenocarcinomas do cólon 17,[25][26][27] , o que não foi observado por outros autores 28 . Outro estudo revelou os tipos 16 e 18 do HPV em 67% dos carcinomas e em 56% dos adenomas do cólon e em 28% das vezes na mucosa normal 25 .…”

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“…É necessária a sua integração no genoma do hospedeiro, bem como que haja expressão das oncoproteínas virais. Nesse aspecto, a correlação entre a infecção pelo HPV, a amplificação do c-myc 11 , a mutação k-ras 11,12 e a mutação ou polimorfismo da p53 30 foram investigados e, embora sejam eventos frequentes, a possível função viral na carcinogênese colorretal não foi definida 17 .…”

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Papilomavírus humano e sua associação com o carcinoma colorretal

Manzione¹,

Nadal²

2010

Rev bras. colo-proctol.

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RESUMO: Atualmente, sabe-se que 15% dos tumores malignos humanos têm associação com infecções virais. Destes, 80% correspondem aos carcinomas da cérvix uterina, associados ao papilomavírus humano (HPV), e aos hepatocarcinomas. Nos últimos anos, entretanto, artigos da literatura especializada vêm mostrando a presença do DNA do HPV em amostras de tecido de carcinomas do esôfago, estômago, pulmão, da mama e do cólon e reto, o que foi negado por outros autores. O HPV vem sendo encontrado entre 41,7 e 82,1% dos adenocarcinomas e entre 28 e 56% dos adenomas do cólon. Embora o DNA viral esteja integrado ao tumoral, a maneira de contaminação não é evidente. As vias linfáticas e hematogênicas não são reconhecidas. Fica a dúvida quanto à especificidade dos exames de detecção viral e quanto às formas de disseminação viral para os segmentos mais proximais do cólon. De qualquer forma, a literatura não é categórica em afirmar se esse vírus pode ser agente causal da doença, sendo necessários mais estudos para definir esse assunto.Descritores: Infecções por papilomavírus; Cancer colorretal. Desses últimos citados, o CEC é o mais comum na região anal. É conhecida sua associação como HPV em até 93% dos doentes 2-5 , o que desencadeou vários estudos no sentido de elaborar métodos de detecção e tratamento da lesão precursora, a neoplasia intraepitelial anal (NIA), incluindo a citologia oncótica, os métodos de detecção do DNA viral e o uso do colposcópio 5-12 , com intuito de reduzir a incidência dessa doença. Papilomavírus humano e sua associação com o carcinoma colorretalNos últimos anos, entretanto, artigos da literatura especializada vêm mostrando a presença do DNA do HPV em amostras de tecido de carcinomas do esôfa-go 13 , estômago 14,15 , pulmão 14 , mama 16 e colorretal [17][18][19] . O HPV foi detectado em até 37,5% dos adenocarcinomas gástricos 15 , e em 27,8% dos CEC esofágicos 20 , havendo diferença em áreas de alta e de baixa prevalência para esse tumor maligno (65 e 6%, respectivamente) 21 . O HPV associado ao carcinoma da mama tem sido descrito em 24,5% dos casos, ocorrendo em 32,4% das asiáticas e em 12,9% das mulheres na Europa 22 , geralmente, naquelas com neoplasias intraepiteliais cervicais de alto grau 16 . O HPV foi detectado em 51,4% dos CEC e em 16,2% dos adenocarcinomas do pulmão, sendo que o risco de CEC pulmonar é 3,5 vezes maior em doentes contaminados pelo HPV 23 , embora, outros neguem essa associação 24 . O HPV foi encontrado entre 41,7 e

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Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature

Cited by 44 publications

References 22 publications

Anal cancer and cervical cancer screening: Key differences

Anal cancer and cervical cancer screening: Key differences

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

Papilomavírus humano e sua associação com o carcinoma colorretal

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