Human papillomavirus-16 DNA in a cutaneous invasive cancer

Ostrow, R. S.

doi:10.1001/archderm.125.5.666

Cited by 16 publications

(9 citation statements)

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“…15 More recently, HPV has been implicated in digital SCC. [7][8][9][15][16][17][18][19][20] A possible association between genital and digital SCC has been presented in several studies, suggesting venereal transmission of the virus. 9,15,16 The association of HPV with SCC in locations other than the digits and genital tract is rare, 16 with exceptions noted in the periorbital skin, 21 where HPV 16-associated SCC has been described.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus‐associated squamous cell carcinoma of the nail bed in African‐American patients

2009

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus‐associated squamous cell carcinoma of the nail bed in African‐American patients

2009

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“…Hitherto, there has been little evidence of HPV 16 as an aetiological factor in skin cancers except for squamous cell carcinoma (SCC) of the fingers. 3–14 Indication of transmission of HPV infections between the genital tract and the fingers has come from one man with HPV 16 simultaneously in lesions on a finger and in penile Bowen’s disease (BD), and from a woman with HPV 16/18 in both a subungual SCC and in uterine cervical intraepithelial neoplasia 9,15 . In two cases reported by us, HPV 16 was found in genital dysplasia and in subsequent (up to 26 years later) BD on the fingers.…”

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confidence: 99%

Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers

Forslund

Nordin

Hansson

2000

British Journal of Dermatology

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Human papillomavirus (HPV), especially type 16, is causally involved in the pathogenesis of anogenital cancer. There is an increasing number of reports of HPV infections in squamous cell carcinoma (SCC) of the fingers. A search of the Swedish cancer register covering the period 1958-94 inclusive for women with a history of genital and upper extremity SCC revealed 63 cases. Archival material from both cervical and cutaneous lesions was traced and analysed for the presence of HPV DNA in 32 of these patients. A newly developed 'neighbour primer' polymerase chain reaction (PCR) for HPV 16 DNA, aimed at overcoming the obstacle of cross-linked target DNA, was shown to be superior to conventional general and type-specific HPV PCR tests. HPV DNA was significantly more frequently found in digital tumours than in tumours at other cutaneous sites of the upper extremities [67% (10 of 15) vs. 7% (three of 43); P < 0.001]. Among 13 patients with a history of both cervical and finger SCC, HPV 16 was found in cervical samples from seven patients. From five of these seven patients, HPV 16 was also present in the corresponding finger lesions. The results support the hypothesis of a possible transmission of patients' genital HPV infections to fingers.

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“…HPV16 DNA, which was detected in the present tumour, has been commonly linked with both genital neoplasia and cutaneous bowenoid lesions (13). Hybridization signals among the positive cells often vary in intensity and distribution and can be classi®ed into three distinct patterns: weak diffuse nuclear staining, suggested as indicative of episomal, non-productive infection; strong nuclear staining with cytoplasmic positivity; and a distinct punctate nuclear signal suggested, in cervical carcinoma (10), to represent viral integration.…”

Section: Discussionmentioning

confidence: 81%

Histological Diagnosis of Cutaneous "Warty" Carcinoma on a Pre-existing HPV Lesion

Aroni

Lazaris²,

Ioakim-Liossi³

et al. 2000

Acta Dermato-Venereologica

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A middle-aged man with an 8-year history of a fungating tumour mass on his thigh was histologically diagnosed as having an invasive "warty" carcinoma at the location of a pre-existing human papillomavirus (HPV) lesion. The tumour surface had a verruciform appearance with papillae containing fibrovascular cores. Many of the malignant cells displayed changes consistent with koilocytotic atypia. We noticed a greater degree of nuclear atypia in comparison with a verrucous carcinoma. Focally, some neoplastic cells demonstrated features of basaloid differentiation. Under in situ hybridization conditions, only HPV16 DNA, which is commonly associated with genital neoplasia, was detected selectively in rather superficial areas, corresponding to morphological evidence of HPV infection (i.e. koilocytotic atypia). It is worth noting that cutaneous location of such a warty carcinoma is very rare.

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Human papillomavirus-16 DNA in a cutaneous invasive cancer

Cited by 16 publications

References 0 publications

Human papillomavirus‐associated squamous cell carcinoma of the nail bed in African‐American patients

Human papillomavirus‐associated squamous cell carcinoma of the nail bed in African‐American patients

Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers

Histological Diagnosis of Cutaneous "Warty" Carcinoma on a Pre-existing HPV Lesion

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